The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable (Q28539752)

6

0 references

Carly S Filgueira

object named as

Carly S Filgueira

3

0 references

Robert Fletterick

8

object named as

Robert J Fletterick

0 references

author name string

Cindy Benod

1

0 references

Rosa Villagomez

2

0 references

Peter K Hwang

4

0 references

Paul G Leonard

5

0 references

Senapathy Rajagopalan

7

0 references

Jan-Åke Gustafsson

9

0 references

Paul Webb

Creative Commons Attribution 4.0 International

10

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language of work or name

English

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publication date

2014

0 references

published in

PLOS One

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volume

9

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issue

6

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page(s)

e99440

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copyright license

start time

17 June 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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The Crystal Structure of the Orphan Nuclear Receptor NR2E3/PNR Ligand Binding Domain Reveals a Dimeric Auto-Repressed Conformation

19 March 2017

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The oncoprotein BCL11A binds to orphan nuclear receptor TLX and potentiates its transrepressive function

19 March 2017

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Histone demethylase LSD1 regulates neural stem cell proliferation

19 March 2017

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The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1

19 March 2017

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Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor

19 March 2017

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An integrated genomic analysis of human glioblastoma multiforme

19 March 2017

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Structural determination of estrogen-related receptor gamma in the presence of phenol derivative compounds

19 March 2017

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Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain

19 March 2017

1 reference

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Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation

19 March 2017

1 reference

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Overview of nomenclature of nuclear receptors

19 March 2017

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Expression and function of orphan nuclear receptor TLX in adult neural stem cells

19 March 2017

1 reference

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Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors

19 March 2017

1 reference

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The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

19 March 2017

1 reference

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New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

7 April 2017

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Comparative protein structure modeling using Modeller

7 April 2017

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On the analysis of protein self-association by sedimentation velocity analytical ultracentrifugation

7 April 2017

1 reference

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Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

7 April 2017

1 reference

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Structure-based discovery of antagonists of nuclear receptor LRH-1.

7 April 2017

1 reference

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Characterization of TLX expression in neural stem cells and progenitor cells in adult brains

29 September 2017

1 reference

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The Neural Stem Cell Fate Determinant TLX Promotes Tumorigenesis and Genesis of Cells Resembling Glioma Stem Cells

29 September 2017

1 reference

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Nuclear receptors in stem cells and their therapeutic potential

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060991

The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060991

Gliomagenesis and the use of neural stem cells in brain tumor treatment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060991

Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060991

Neural stem cells in the developing and adult brains

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060991

Database searching and accounting of multiplexed precursor and product ion spectra from the data independent analysis of simple and complex peptide mixtures

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060991

Transrepressive function of TLX requires the histone demethylase LSD1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060991

A role for adult TLX-positive neural stem cells in learning and behaviour

29 September 2017

1 reference

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Neural stem cell self-renewal

29 September 2017

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Radial glia cells are candidate stem cells of ependymoma

29 September 2017

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Absolute quantification of proteins by LCMSE: a virtue of parallel MS acquisition

29 September 2017

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Structure-based design of potent retinoid X receptor alpha agonists

29 September 2017

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Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor Tlx.

29 September 2017

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Nuclear orphan receptor TLX induces Oct-3/4 for the survival and maintenance of adult hippocampal progenitors upon hypoxia

29 September 2017

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The nuclear receptor ligand-binding domain: structure and function

3 June 2018

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Nuclear Receptors as Drug Targets: New Developments in Coregulators, Orphan Receptors and Major Therapeutic Areas

21 January 2018

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TLX activates MASH1 for induction of neuronal lineage commitment of adult hippocampal neuroprogenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0099440

Identification of tumor-specific molecular signatures in intracranial ependymoma and association with clinical characteristics.

21 January 2018

1 reference

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Neurocytoma is a tumor of adult neuronal progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0099440

Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0099440

Orphan nuclear receptors--new ligands and new possibilities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0099440

Sedimentation equilibrium analysis of protein interactions with global implicit mass conservation constraints and systematic noise decomposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0099440

ViTO: tool for refinement of protein sequence-structure alignments

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24936658

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Quantitative proteomic analysis by accurate mass retention time pairs

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24936658

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0099440

1 reference

ADS bibcode

2014PLoSO...999440B

0 references

1 reference

1 reference

PubMed publication ID

24936658

1 reference