The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds (Q28545089)

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English	The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds	scientific article

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The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds (English)

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Karsten Melcher

6

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Nanda-Kumar Sasi

object named as

Nanda Kumar Sasi

1

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author name string

Kanchan Tiwari

2

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Fen-Fen Soon

3

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Dorine Bonte

4

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Tong Wang

5

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H Eric Xu

7

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Michael Weinreich

8

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publication date

2014

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9

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11

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e113300

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Creative Commons Attribution 4.0 International

20 November 2014

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April 2022 Public Data File from Crossref

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describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4239038/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Crystal structure of human CDC7 kinase in complex with its activator DBF4

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Mechanism of cancer cell death induced by depletion of an essential replication regulator

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19 March 2017

Discovery of XL413, a potent and selective CDC7 inhibitor

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How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

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First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery

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19 March 2017

Dbf4-dependent CDC7 kinase links DNA replication to the segregation of homologous chromosomes in meiosis I.

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Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination

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Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

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CDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 protein

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Gene expression in poorly differentiated papillary thyroid carcinomas

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Identification of Mcm2 phosphorylation sites by S-phase-regulating kinases

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19 March 2017

Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells

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The conformational plasticity of protein kinases

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Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication

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mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p

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Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast

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29 September 2017

ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress

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Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models

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Expression of huCdc7 in colorectal cancer

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Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4239038

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Physiological relevance of cell cycle kinases

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Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication

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Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding.

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Molecular architecture of the DNA replication origin activation checkpoint

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ATR-dependent activation of p38 MAP kinase is responsible for apoptotic cell death in cells depleted of Cdc7.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4239038

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0113300

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https://pubmed.ncbi.nlm.nih.gov/25412417

12 December 2020

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Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells

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https://pubmed.ncbi.nlm.nih.gov/25412417

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0113300

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2014PLoSO...9k3300S

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Consolidated OpenCitations Corpus – April 2017

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PMC publication ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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