High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells (Q28547125)

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Language	Label	Description	Also known as
English	High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells	scientific article

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High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells (English)

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2

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Rita Sattler

author given names

Rita

author last names

Sattler

1 reference

20 October 2023

Barbara S Slusher

9

author given names

Barbara S

author last names

Slusher

object named as

Barbara S Slusher

1 reference

20 October 2023

1

author given names

Ajit G

author last names

Thomas

object named as

Ajit G Thomas

1 reference

20 October 2023

author name string

Karen Tendyke

3

author given names

Karen

author last names

Tendyke

1 reference

20 October 2023

Kara A Loiacono

4

author given names

Kara A

author last names

Loiacono

1 reference

20 October 2023

Hans Hansen

5

author given names

Hans

author last names

Hansen

1 reference

20 October 2023

Vishal Sahni

6

author given names

Vishal

author last names

Sahni

1 reference

20 October 2023

Yutaka Hashizume

7

author given names

Yutaka

author last names

Hashizume

1 reference

20 October 2023

Camilo Rojas

8

author given names

Camilo

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Rojas

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20 October 2023

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publication date

2015

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10

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8

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e0127785

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copyright license

Creative Commons Attribution 4.0 International

7 August 2015

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April 2022 Public Data File from Crossref

copyright status

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Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells

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Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange

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Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B

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Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target

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System x(c)(-) regulates microglia and macrophage glutamate excitotoxicity in vivo

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Increased expression of cystine/glutamate antiporter in multiple sclerosis

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Conformationally-restricted amino acid analogues bearing a distal sulfonic acid show selective inhibition of system x(c)(-) over the vesicular glutamate transporter

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29 September 2017

Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc- as a neuroprotective drug target

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Isoxazole analogues bind the system xc- transporter: structure-activity relationship and pharmacophore model

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Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-kappaB.

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Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase

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Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema.

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29 September 2017

The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases

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Autocrine glutamate signaling promotes glioma cell invasion.

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29 September 2017

Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation.

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Redox imbalance in cystine/glutamate transporter-deficient mice

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29 September 2017

Inhibition of cystine uptake disrupts the growth of primary brain tumors

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Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells

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Transport of L-[14C]cystine and L-[14C]cysteine by subtypes of high affinity glutamate transporters over-expressed in HEK cells

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Differentiation of substrate and non-substrate inhibitors of transport system xc(-): an obligate exchanger of L-glutamate and L-cystine

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Malignant gliomas: perverting glutamate and ion homeostasis for selective advantage.

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Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment

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Glioma cells release excitotoxic concentrations of glutamate.

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Effect of glutathione-modulating compounds on hydrogen-peroxide-induced cytotoxicity in human glioblastoma and glioma cell lines

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Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation.

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3 June 2018

Cystine requirement of continuous human lymphoid cell lines of normal and leukemic origin

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3 June 2018

Glutamate release promotes growth of malignant gliomas

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System xc- and glutamate transporter inhibition mediates microglial toxicity to oligodendrocytes.

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System Xc- and apolipoprotein E expressed by microglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40.

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21 January 2018

Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.

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21 January 2018

Loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility.

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21 January 2018

Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug

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21 January 2018

The Nubase evaluation of nuclear and decay properties

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Glutaminolysis: supplying carbon or nitrogen or both for cancer cells?

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Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity.

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Implementation of a continuous, enzyme-coupled fluorescence assay for high-throughput analysis of glutamate-producing enzymes

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture

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https://pubmed.ncbi.nlm.nih.gov/26252954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport of cystine and cysteine and cell growth in cultured human diploid fibroblasts: effect of glutamate and homocysteate

1 reference

https://pubmed.ncbi.nlm.nih.gov/26252954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exchange of cystine and glutamate across plasma membrane of human fibroblasts

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https://pubmed.ncbi.nlm.nih.gov/26252954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/26252954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0127785

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2015PLoSO..1027785T

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