Phospholipase C, delta 1 (Q28557592)

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mammalian protein found in Rattus norvegicus

phospholipase C-III
PLC-III
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
Plcd1
phosphoinositide phospholipase C
PLC-delta-1
Phospholipase C-delta1
phospholipase C delta 1 long form
phosphoinositide phospholipase C-delta-1

Language	Label	Description	Also known as
English	Phospholipase C, delta 1	mammalian protein found in Rattus norvegicus	phospholipase C-III PLC-III 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Plcd1 phosphoinositide phospholipase C PLC-delta-1 Phospholipase C-delta1 phospholipase C delta 1 long form phosphoinositide phospholipase C-delta-1

Statements

1 reference

17 November 2021

UniProt protein ID

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10688

EF-hand domain pair

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10688

C2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10688

PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10688

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10688

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

EF-hand domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

C2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphatidylinositol-specific phospholipase C, X domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phospholipase C, phosphatidylinositol-specific, Y domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphoinositide-specific phospholipase C, EF-hand-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EF-Hand 1, calcium-binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

UniProt protein ID

1 reference

17 November 2021

UniProt protein ID

molecular function

phosphatidylinositol phospholipase C activity

determination method or standard

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

14 February 2019

Phosphoinositide-specific phospholipase C delta1 activity toward micellar substrates, inositol 1,2-cyclic phosphate, and other water-soluble substrates: a sequential mechanism and allosteric activation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

calcium ion binding

determination method or standard

3 references

14 February 2019

Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

14 February 2019

Catalysis by phospholipase C delta1 requires that Ca2+ bind to the catalytic domain, but not the C2 domain

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

protein binding

determination method or standard

3 references

14 February 2019

Recruitment and activation of phospholipase C (PLC)-delta1 in lipid rafts by muscarinic stimulation of PC12 cells: contribution of p122RhoGAP/DLC1, a tumor-suppressing PLCdelta1 binding protein

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

14 February 2019

A novel follicle-stimulating hormone-induced G alpha h/phospholipase C-delta1 signaling pathway mediating rat sertoli cell Ca2+-influx

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

phospholipid binding

determination method or standard

1 reference

14 February 2019

Membrane activity of the phospholipase C-delta1 pleckstrin homology (PH) domain

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

calcium-dependent phospholipid binding

determination method or standard

1 reference

14 February 2019

Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

phosphoric diester hydrolase activity

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

hydrolase activity

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

metal ion binding

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

inositol 1,4,5 trisphosphate binding

determination method or standard

1 reference

14 February 2019

Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

determination method or standard

1 reference

14 February 2019

Phospholipase Cdelta1 associates with importin beta1 and translocates into the nucleus in a Ca2+-dependent manner

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

determination method or standard

determination method or standard

1 reference

14 February 2019

A novel follicle-stimulating hormone-induced G alpha h/phospholipase C-delta1 signaling pathway mediating rat sertoli cell Ca2+-influx

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

mitochondrial membranes

determination method or standard

1 reference

14 February 2019

Novel role of phospholipase C-delta1: regulation of liver mitochondrial Ca2+ uptake

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

determination method or standard

1 reference

14 February 2019

Recruitment and activation of phospholipase C (PLC)-delta1 in lipid rafts by muscarinic stimulation of PC12 cells: contribution of p122RhoGAP/DLC1, a tumor-suppressing PLCdelta1 binding protein

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

biological process

G protein-coupled receptor signaling pathway

determination method or standard

1 reference

14 February 2019

Evidence that phospholipase delta1 is the effector in the Gh (transglutaminase II)-mediated signaling

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

response to aluminum ion

determination method or standard

1 reference

14 February 2019

Increase in phospholipase C-delta1 protein levels in aluminum-treated rat brains

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

response to organonitrogen compound

determination method or standard

1 reference

14 February 2019

Effects of hyperoxia and acrylonitrile on the phospholipase C isozyme protein levels in rat heart and brain

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

positive regulation of norepinephrine secretion

determination method or standard

1 reference

14 February 2019

Phospholipase C-delta1 is activated by capacitative calcium entry that follows phospholipase C-beta activation upon bradykinin stimulation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

lipid catabolic process

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

positive regulation of inositol trisphosphate biosynthetic process

determination method or standard

1 reference

14 February 2019

A novel follicle-stimulating hormone-induced G alpha h/phospholipase C-delta1 signaling pathway mediating rat sertoli cell Ca2+-influx

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

response to prostaglandin F

determination method or standard

1 reference

14 February 2019

Opposite effect of prolactin and prostaglandin F(2 alpha) on the expression of luteal genes as revealed by rat cDNA expression array

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

intracellular signal transduction

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

response to peptide hormone

determination method or standard

1 reference

14 February 2019

A novel follicle-stimulating hormone-induced G alpha h/phospholipase C-delta1 signaling pathway mediating rat sertoli cell Ca2+-influx

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

regulation of cytosolic calcium ion concentration

determination method or standard

1 reference

14 February 2019

Novel regulation of PLCζ activity via its XY-linker

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

determination method or standard

1 reference

14 February 2019

A novel follicle-stimulating hormone-induced G alpha h/phospholipase C-delta1 signaling pathway mediating rat sertoli cell Ca2+-influx

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

response to calcium ion

determination method or standard

1 reference

14 February 2019

Phospholipase C-delta1 is activated by capacitative calcium entry that follows phospholipase C-beta activation upon bradykinin stimulation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

response to hyperoxia

determination method or standard

1 reference

14 February 2019

Effects of hyperoxia and acrylonitrile on the phospholipase C isozyme protein levels in rat heart and brain

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

regulation of phospholipase C activity

determination method or standard

1 reference

14 February 2019

Novel regulation of PLCζ activity via its XY-linker

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

inositol trisphosphate biosynthetic process

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10688

determination method or standard

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10688

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10688

EF-hand 1, calcium-binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10688

pleckstrin homology domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10688

Phosphoinositide-specific phospholipase C, EF-hand-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10688

Phosphatidylinositol-specific phospholipase C, X domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10688

Phospholipase C, phosphatidylinositol-specific, Y domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10688

Identifiers

RefSeq protein ID

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

UniProt protein ID

1 reference

17 November 2021

UniProt protein ID

Ensembl protein ID

ENSRNOP00000042824

1 reference

ensembl Release 104

Ensembl protein ID

ENSRNOP00000042824

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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