Translocator protein (Q28558111)

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mammalian protein found in Rattus norvegicus

peripheral-type benzodiazepine receptor
translocator protein
Tspo
PKBS
mitochondrial benzodiazepine receptor
PBR
Benzodiazepin receptor (peripheral)
benzodiazepine receptor, peripheral

Language	Label	Description	Also known as
English	Translocator protein	mammalian protein found in Rattus norvegicus	peripheral-type benzodiazepine receptor translocator protein Tspo PKBS mitochondrial benzodiazepine receptor PBR Benzodiazepin receptor (peripheral) benzodiazepine receptor, peripheral

Statements

1 reference

25 May 2022

UniProt protein ID

Translocator protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16257

TspO/MBR-related superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16257

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

androgen binding

determination method

1 reference

14 February 2019

Direct interactions of androgenic/anabolic steroids with the peripheral benzodiazepine receptor in rat brain: implications for the psychological and physiological manifestations of androgenic/anabolic steroid abuse

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

protein binding

determination method

1 reference

14 February 2019

The peripheral-type benzodiazepine receptor is involved in control of Ca2+-induced permeability transition pore opening in rat brain mitochondria

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

benzodiazepine receptor activity

determination method

1 reference

14 February 2019

Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

cholesterol binding

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

transmembrane transporter binding

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

determination method

4 references

14 February 2019

Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

14 February 2019

Overexpression of translocator protein in inflammatory bowel disease: potential diagnostic and treatment value

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

mitochondrial outer membrane

determination method

1 reference

14 February 2019

TSPO targeted dendrimer imaging agent: synthesis, characterization, and cellular internalization

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

endoplasmic reticulum

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

integral component of membrane

determination method

mitochondrial membranes

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

biological process

steroid biosynthetic process

determination method

1 reference

14 February 2019

Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the R2C Leydig tumor cell line

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

determination method

1 reference

14 February 2019

Functional characterization and expression of PBR in rat gastric mucosa: stimulation of chloride secretion by PBR ligands

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

chloride transport

determination method

1 reference

14 February 2019

Functional characterization and expression of PBR in rat gastric mucosa: stimulation of chloride secretion by PBR ligands

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

lipid transport

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

determination method

1 reference

14 February 2019

Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

glial cell migration

determination method

1 reference

14 February 2019

TSPO over-expression increases motility, transmigration and proliferation properties of C6 rat glioma cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

response to manganese ion

determination method

1 reference

14 February 2019

Upregulation of 'peripheral-type' benzodiazepine receptors in the globus pallidus in a sub-acute rat model of manganese neurotoxicity

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

response to vitamin B1

determination method

1 reference

14 February 2019

Increased "peripheral-type" benzodiazepine receptor sites and mRNA in thalamus of thiamine-deficient rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

negative regulation of mitochondrion organization

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

positive regulation of necrotic cell death

determination method

1 reference

14 February 2019

Involvement of peripheral benzodiazepine receptor in the oxidative stress, death-signaling pathways, and renal injury induced by ischemia-reperfusion

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

peripheral nervous system axon regeneration

determination method

1 reference

14 February 2019

Enhanced expression of the peripheral benzodiazepine receptor (PBR) and its endogenous ligand octadecaneuropeptide (ODN) in the regenerating adult rat sciatic nerve

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

adrenal gland development

determination method

1 reference

14 February 2019

Developmental expression of the peripheral-type benzodiazepine receptor and the advent of steroidogenesis in rat adrenal glands

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

negative regulation of protein ubiquitination

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

response to progesterone

determination method

1 reference

14 February 2019

Modulation of peripheral benzodiazepine receptors in female rat genital organs by various gonadal steroids

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

negative regulation of tumor necrosis factor production

determination method

1 reference

14 February 2019

Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

response to testosterone

determination method

1 reference

14 February 2019

Modulation of peripheral benzodiazepine receptors in female rat genital organs by various gonadal steroids

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

positive regulation of apoptotic process

determination method

1 reference

14 February 2019

Involvement of peripheral benzodiazepine receptor in the oxidative stress, death-signaling pathways, and renal injury induced by ischemia-reperfusion

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

negative regulation of nitric oxide biosynthetic process

determination method

1 reference

14 February 2019

Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

response to pain

determination method

1 reference

14 February 2019

Spinal translocator protein (TSPO) modulates pain behavior in rats with CFA-induced monoarthritis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

behavioral response to pain

determination method

1 reference

14 February 2019

Spinal translocator protein (TSPO) modulates pain behavior in rats with CFA-induced monoarthritis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

response to axon injury

determination method

1 reference

14 February 2019

Axonal injury-dependent induction of the peripheral benzodiazepine receptor in small-diameter adult rat primary sensory neurons

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

regulation of steroid biosynthetic process

determination method

1 reference

14 February 2019

Regulation of the expression of peripheral benzodiazepine receptors and their endogenous ligands during rat sciatic nerve degeneration and regeneration: a role for PBR in neurosteroidogenesis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

positive regulation of mitochondrial depolarization

determination method

1 reference

14 February 2019

Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

positive regulation of calcium ion transport

determination method

1 reference

14 February 2019

The peripheral-type benzodiazepine receptor is involved in control of Ca2+-induced permeability transition pore opening in rat brain mitochondria

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

contact inhibition

determination method

1 reference

14 February 2019

TSPO over-expression increases motility, transmigration and proliferation properties of C6 rat glioma cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

positive regulation of glial cell proliferation

determination method

1 reference

14 February 2019

TSPO over-expression increases motility, transmigration and proliferation properties of C6 rat glioma cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

negative regulation of glial cell proliferation

determination method

1 reference

14 February 2019

Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

cellular response to lipopolysaccharide

determination method

1 reference

14 February 2019

Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

cellular response to zinc ion

determination method

1 reference

14 February 2019

Hypoosmotic swelling affects zinc homeostasis in cultured rat astrocytes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

cellular hypotonic response

determination method

1 reference

14 February 2019

Hypoosmotic swelling affects zinc homeostasis in cultured rat astrocytes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

establishment of protein localization to mitochondrion

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

maintenance of protein location in mitochondrion

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

negative regulation of autophagy of mitochondrion

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

negative regulation of ATP metabolic process

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16257

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSRNOP00000014089

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000014089

Sitelinks

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Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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