Calcium voltage-gated channel auxiliary subunit beta 3 (Q28558490)

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mammalian protein found in Rattus norvegicus

CAB3
Calcium channel subunit beta 3
voltage-dependent L-type calcium channel subunit beta-3
calcium channel voltage-dependent subunit beta 3
calcium channel, voltage-dependent, beta 3 subunit
Cacnb3

Language	Label	Description	Also known as
English	Calcium voltage-gated channel auxiliary subunit beta 3	mammalian protein found in Rattus norvegicus	CAB3 Calcium channel subunit beta 3 voltage-dependent L-type calcium channel subunit beta-3 calcium channel voltage-dependent subunit beta 3 calcium channel, voltage-dependent, beta 3 subunit Cacnb3

Statements

1 reference

17 November 2021

UniProt protein ID

Voltage-dependent calcium channel, L-type, beta-3 subunit

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54287

SH3-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54287

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54287

Voltage-dependent L-type calcium channel subunit beta-3, SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Guanylate kinase/L-type calcium channel beta subunit, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

UniProt protein ID

1 reference

17 November 2021

UniProt protein ID

molecular function

voltage-gated ion channel activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

voltage-gated calcium channel activity

determination method

4 references

14 February 2019

Cloning and expression of a neuronal calcium channel beta subunit

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

14 February 2019

The voltage-dependent calcium channel beta subunit contains two stable interacting domains

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

calcium channel regulator activity

determination method

1 reference

14 February 2019

Ca(2+) channel modulation by recombinant auxiliary beta subunits expressed in young adult heart cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

calcium channel activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

protein binding

determination method

4 references

14 February 2019

BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

14 February 2019

Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

14 February 2019

Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

14 February 2019

Direct inhibition of P/Q-type voltage-gated Ca 2+ channels by Gem does not require a direct Gem/Ca v β interaction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

protein kinase binding

determination method

1 reference

14 February 2019

Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

voltage-gated calcium channel complex

determination method

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

14 February 2019

Cloning and expression of a neuronal calcium channel beta subunit

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

apical plasma membrane

determination method

1 reference

14 February 2019

Apical GLUT2 and Cav1.3: regulation of rat intestinal glucose and calcium absorption

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

L-type voltage-gated calcium channel complex

determination method

3 references

14 February 2019

Ca(2+) channel modulation by recombinant auxiliary beta subunits expressed in young adult heart cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

14 February 2019

Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

14 February 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

biological process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

calcium ion transport

determination method

3 references

14 February 2019

The voltage-dependent calcium channel beta subunit contains two stable interacting domains

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

chemical synaptic transmission

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

neuromuscular junction development

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

regulation of ion transmembrane transport

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

T cell receptor signaling pathway

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

detection of mechanical stimulus involved in sensory perception of pain

determination method

1 reference

14 February 2019

Up-regulation of Cavβ3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

calcium ion transport into cytosol

determination method

1 reference

14 February 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

calcium ion transmembrane transport via high voltage-gated calcium channel

determination method

calcium ion transmembrane transport

determination method

3 references

protein localization to plasma membrane

determination method

1 reference

14 February 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

positive regulation of protein targeting to membrane

determination method

1 reference

14 February 2019

Molecular determinants of the CaVbeta-induced plasma membrane targeting of the CaV1.2 channel

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

cellular response to oxygen-glucose deprivation

determination method

1 reference

14 February 2019

trans-Resveratrol protects ischemic PC12 Cells by inhibiting the hypoxia associated transcription factors and increasing the levels of antioxidant defense enzymes.

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

regulation of membrane repolarization during action potential

determination method

1 reference

14 February 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

regulation of voltage-gated calcium channel activity

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

negative regulation of voltage-gated calcium channel activity

determination method

1 reference

14 February 2019

Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

positive regulation of voltage-gated calcium channel activity

determination method

1 reference

14 February 2019

Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

positive regulation of high voltage-gated calcium channel activity

determination method

regulation of membrane hyperpolarization

determination method

1 reference

14 February 2019

Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

negative regulation of detection of mechanical stimulus involved in sensory perception of touch

determination method

1 reference

14 February 2019

Up-regulation of Cavβ3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

positive regulation of excitatory postsynaptic potential

determination method

1 reference

14 February 2019

Up-regulation of Cavβ3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54287

determination method

Guanylate kinase/L-type calcium channel beta subunit

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54287

Voltage-dependent L-type calcium channel subunit beta-3, SH3 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54287

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54287

Identifiers

RefSeq protein ID

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

UniProt protein ID

1 reference

17 November 2021

UniProt protein ID

Ensembl protein ID

ENSRNOP00000073026

1 reference

ensembl Release 104

Ensembl protein ID

ENSRNOP00000073026

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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