TNF receptor superfamily member 1A (Q28558966)

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mammalian protein found in Rattus norvegicus

tumor necrosis factor receptor type I
TNF-R1
Tnfrsf1a
p55
tumor necrosis factor receptor 1
tumor necrosis factor receptor superfamily, member 1a
TNF-RI
TNFR-I
tumor necrosis factor receptor superfamily member 1A
p60

Language	Label	Description	Also known as
English	TNF receptor superfamily member 1A	mammalian protein found in Rattus norvegicus	tumor necrosis factor receptor type I TNF-R1 Tnfrsf1a p55 tumor necrosis factor receptor 1 tumor necrosis factor receptor superfamily, member 1a TNF-RI TNFR-I tumor necrosis factor receptor superfamily member 1A p60

Statements

1 reference

17 November 2021

UniProt protein ID

Tumour necrosis factor receptor 1A

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22934

Death-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22934

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Tumor necrosis factor receptor 1A, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tumor necrosis factor receptor 1A, death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TNFR/NGFR cysteine-rich region, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

UniProt protein ID

1 reference

17 November 2021

UniProt protein ID

molecular function

protease binding

determination method

1 reference

14 February 2019

14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

tumor necrosis factor-activated receptor activity

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

14 February 2019

14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

protein binding

determination method

1 reference

14 February 2019

14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

tumor necrosis factor binding

determination method

2 references

protein-containing complex binding

determination method

1 reference

14 February 2019

Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

determination method

2 references

extracellular space

determination method

1 reference

14 February 2019

14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

determination method

1 reference

14 February 2019

Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

Golgi apparatus

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

determination method

1 reference

14 February 2019

Characterization of DISC formation and TNFR1 translocation to mitochondria in TNF-α-treated hepatocytes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

plasma membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

determination method

1 reference

14 February 2019

14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

integral component of membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

determination method

1 reference

14 February 2019

Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

receptor complex

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

determination method

1 reference

14 February 2019

Contribution of TNF receptor 1 to retinal neural cell death induced by elevated glucose

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

biological process

response to hypoxia

determination method

1 reference

14 February 2019

Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

prostaglandin metabolic process

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

apoptotic process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

defense response

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

inflammatory response

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

14 February 2019

Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

signal transduction

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

cell surface receptor signaling pathway

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

response to wounding

determination method

1 reference

14 February 2019

Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

positive regulation of gene expression

determination method

1 reference

14 February 2019

Tumor necrosis factor α primes cerebral endothelial cells for erythropoietin-induced angiogenesis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

negative regulation of gene expression

determination method

1 reference

14 February 2019

Contribution of TNF-alpha and nuclear factor-kappaB signaling to type 2 iodothyronine deiodinase activation in the mediobasal hypothalamus after lipopolysaccharide administration

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

cytokine-mediated signaling pathway

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

response to lipopolysaccharide

determination method

1 reference

14 February 2019

Cell-specific expression and lipopolysaccharide-induced regulation of tumor necrosis factor alpha (TNFalpha) and TNF receptors in rat dorsal root ganglion

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

negative regulation of interleukin-6 production

determination method

1 reference

14 February 2019

Contribution of TNF-alpha and nuclear factor-kappaB signaling to type 2 iodothyronine deiodinase activation in the mediobasal hypothalamus after lipopolysaccharide administration

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

positive regulation of tumor necrosis factor production

determination method

1 reference

14 February 2019

Astrocyte reactivity to unconjugated bilirubin requires TNF-α and IL-1β receptor signaling pathways

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

regulation of apoptotic process

determination method

1 reference

14 February 2019

Astrocyte reactivity to unconjugated bilirubin requires TNF-α and IL-1β receptor signaling pathways

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

negative regulation of apoptotic process

determination method

1 reference

14 February 2019

Gene network revealed involvements of Birc2, Birc3 and Tnfrsf1a in anti-apoptosis of injured peripheral nerves

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

response to amino acid

determination method

1 reference

14 February 2019

S-Propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: Involvement of TNF signaling and NF-κB pathway in rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

response to alkaloid

determination method

1 reference

14 February 2019

Inhibitory effects of Dendrobium alkaloids on memory impairment induced by lipopolysaccharide in rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

positive regulation of neuron apoptotic process

determination method

1 reference

14 February 2019

Contribution of TNF receptor 1 to retinal neural cell death induced by elevated glucose

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

response to ethanol

determination method

1 reference

14 February 2019

Ethanol increases tumor necrosis factor-alpha receptor-1 (TNF-R1) levels in hepatic, intestinal, and cardiac cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

positive regulation of angiogenesis

determination method

1 reference

14 February 2019

Intramuscular gene transfer of soluble tumor necrosis factor-alpha receptor 1 activates vascular endothelial growth factor receptor and accelerates angiogenesis in a rat model of hindlimb ischemia

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

positive regulation of inflammatory response

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

protein heterooligomerization

determination method

1 reference

14 February 2019

Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

cellular response to estradiol stimulus

determination method

1 reference

14 February 2019

Estradiol increases the expression of TNF-α and TNF receptor 1 in lactotropes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22934

determination method

Identifiers

RefSeq protein ID

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

UniProt protein ID

1 reference

17 November 2021

UniProt protein ID

Ensembl protein ID

ENSRNOP00000042371

1 reference

ensembl Release 104

Ensembl protein ID

ENSRNOP00000042371

Sitelinks

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Multilingual sites(0 entries)

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