Corticotropin releasing hormone (Q28561034)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01143

Corticotropin-releasing factor, protein family

1 reference

based on heuristic

inferred from protein domain or family

Corticotropin-releasing factor conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

2 references

14 February 2019

A single amino acid serves as an affinity switch between the receptor and the binding protein of corticotropin-releasing factor: implications for the design of agonists and antagonists

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

14 February 2019

Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

corticotropin-releasing hormone activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

corticotropin-releasing hormone receptor 1 binding

corticotropin-releasing hormone receptor 2 binding

A single amino acid serves as an affinity switch between the receptor and the binding protein of corticotropin-releasing factor: implications for the design of agonists and antagonists

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

14 February 2019

Three-amino acid motifs of urocortin II and III determine their CRF receptor subtype selectivity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

14 February 2019

Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

cell component

extracellular space

Hypophysiotropic thyrotropin-releasing hormone and corticotropin-releasing hormone neurons of the rat contain vesicular glutamate transporter-2

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

14 February 2019

Ferulic acid-induced anti-depression and prokinetics similar to Chaihu-Shugan-San via polypharmacology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

cytoplasm

1 reference

14 February 2019

Stress and glucocorticoids regulated corticotropin releasing factor in rat prefrontal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

soma

1 reference

14 February 2019

Corticotropin releasing factor-distribution in rat intestine and role in neuroprotection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

varicosity

1 reference

14 February 2019

Distribution of corticotropin-releasing factor binding protein-immunoreactivity in the rat hypothalamus: association with corticotropin-releasing factor-, urocortin 1- and vimentin-immunoreactive fibres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

perikaryon

1 reference

14 February 2019

Aging associated changes in amygdalar corticotropin-releasing hormone (CRH) and CRH-binding protein in Fischer 344 rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

positive regulation of protein phosphorylation

biological process

1 reference

14 February 2019

CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

negative regulation of systemic arterial blood pressure

1 reference

14 February 2019

Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

glucocorticoid biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

inflammatory response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

female pregnancy

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

learning or memory

1 reference

14 February 2019

Modulation of social learning in rats by brain corticotropin-releasing factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

steroid metabolic process

1 reference

14 February 2019

Stress and glucocorticoids regulated corticotropin releasing factor in rat prefrontal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

positive regulation of cell population proliferation

1 reference

14 February 2019

CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

associative learning

1 reference

14 February 2019

Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

hormone-mediated apoptotic signaling pathway

1 reference

14 February 2019

Corticotropin-releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

positive regulation of gene expression

1 reference

14 February 2019

Role of urocortin 2 secreted by the pituitary in the stress-induced suppression of luteinizing hormone secretion in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

negative regulation of gene expression

1 reference

14 February 2019

Role of urocortin 2 secreted by the pituitary in the stress-induced suppression of luteinizing hormone secretion in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

negative regulation of norepinephrine secretion

1 reference

14 February 2019

Role of corticotrophin-releasing hormone in the impairment of counterregulatory responses to hypoglycemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

positive regulation of cell death

1 reference

14 February 2019

Corticotropin releasing factor-distribution in rat intestine and role in neuroprotection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

regulation of serotonin secretion

1 reference

14 February 2019

Effect of lamotrigine and carbamazepine on corticotropin-releasing factor-associated serotonergic transmission in rat dorsal raphe nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

diterpenoid metabolic process

1 reference

14 February 2019

Stress and glucocorticoids regulated corticotropin releasing factor in rat prefrontal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

hypothalamus development

1 reference

14 February 2019

Corticotrophin-releasing factor alters the timing of puberty in the female rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

lung development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

adrenal gland development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

negative regulation of epinephrine secretion

negative regulation of luteinizing hormone secretion

1 reference

14 February 2019

Role of urocortin 2 secreted by the pituitary in the stress-induced suppression of luteinizing hormone secretion in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

locomotory exploration behavior

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

positive regulation of insulin secretion involved in cellular response to glucose stimulus

1 reference

14 February 2019

CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

response to immobilization stress

2 references

response to cocaine

1 reference

14 February 2019

Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

response to estrogen

1 reference

14 February 2019

Influence of electroacupuncture on efficacy of estrogen in regulating hypothalamic reproductive endocrine activity in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

positive regulation of cAMP-mediated signaling

1 reference

14 February 2019

Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

response to ethanol

1 reference

14 February 2019

Effects of acute ethanol on corticotropin-releasing hormone and β-endorphin systems at the level of the rat central amygdala

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

response to ether

1 reference

14 February 2019

Acute ether stress differentially affects corticotropin-releasing factor and urocortin 1 in the Brattleboro rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

response to pain

1 reference

14 February 2019

Differential responses of corticotropin-releasing factor and urocortin 1 to acute pain stress in the rat brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

ion homeostasis

1 reference

14 February 2019

Hypothalamic cocaine- and amphetamine-regulated transcript and corticotrophin releasing factor neurons are stimulated by extracellular volume and osmotic changes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

response to corticosterone

1 reference

14 February 2019

Stress and glucocorticoids regulated corticotropin releasing factor in rat prefrontal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

positive regulation of corticotropin secretion

Role of urocortin 2 secreted by the pituitary in the stress-induced suppression of luteinizing hormone secretion in rats

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

14 February 2019

Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

long-term potentiation

1 reference

14 February 2019

Roles of two subtypes of corticotrophin‐releasing factor receptor in the corticostriatal long‐term potentiation under cocaine withdrawal condition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

positive regulation of digestive system process

1 reference

14 February 2019

Pathways involved in gut mucosal barrier dysfunction induced in adult rats by maternal deprivation: corticotrophin-releasing factor and nerve growth factor interplay

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

negative regulation of cell death

1 reference

14 February 2019

Corticotropin-releasing factor (CRF) and related peptides confer neuroprotection via type 1 CRF receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

negative regulation of glucagon secretion

cellular response to cocaine

1 reference

14 February 2019

Effects of chronic cocaine exposure on corticotropin-releasing hormone binding protein in the central nucleus of the amygdala and bed nucleus of the stria terminalis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

cellular response to dexamethasone stimulus

1 reference

14 February 2019

Stress and glucocorticoids regulated corticotropin releasing factor in rat prefrontal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

positive regulation of calcium ion import

1 reference

14 February 2019

Modulation of Ca2+ influx by corticotropin-releasing factor (CRF) family of peptides via CRF receptors in rat pancreatic beta-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

positive regulation of corticosterone secretion

positive regulation of behavioral fear response

1 reference

14 February 2019

Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01143

Corticotropin-releasing factor domain

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01143

Corticotropin-releasing factor conserved site

1 reference

InterPro Release 71.0