Cofilin 1 (Q28561077)

http://www.ebi.ac.uk/interpro/protein/P45592

Cofilin 1

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P45592

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Actin-depolymerising factor homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

1 reference

17 November 2021

3 references

14 February 2019

Latrunculin B or ATP depletion induces cofilin-dependent translocation of actin into nuclei of mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

signaling receptor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

4 references

14 February 2019

Expression of Actin-interacting Protein 1 Suppresses Impaired Chemotaxis ofDictyosteliumCells Lacking the Na+-H+Exchanger NHE1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

14 February 2019

Identification of Bax-interacting proteins in oligodendrocyte progenitors during glutamate excitotoxicity and perinatal hypoxia-ischemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

14 February 2019

SPIN90 dephosphorylation is required for cofilin-mediated actin depolymerization in NMDA-stimulated hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

14 February 2019

Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

protein phosphatase binding

IPI

1 reference

14 February 2019

Chronophin coordinates cell leading edge dynamics by controlling active cofilin levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

IPI

actin filament binding

3 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

14 February 2019

Activity-dependent dendritic spine shrinkage and growth involve downregulation of cofilin via distinct mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

phosphatidylinositol bisphosphate binding

1 reference

14 February 2019

Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

14 February 2019

Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

14 February 2019

Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

Inhibiting geranylgeranylation increases neurite branching and differentially activates cofilin in cell bodies and growth cones

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

Inhibiting geranylgeranylation increases neurite branching and differentially activates cofilin in cell bodies and growth cones

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

cortical actin cytoskeleton

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

lamellipodium membrane

1 reference

14 February 2019

Myoinositol Attenuates the Cell Loss and Biochemical Changes Induced by Kainic Acid Status Epilepticus

mitochondrial membranes

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

Inhibiting geranylgeranylation increases neurite branching and differentially activates cofilin in cell bodies and growth cones

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

NMDA receptor triggered molecular cascade underlies compression-induced rapid dendritic spine plasticity in cortical neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

neural crest cell migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

neural fold formation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

protein phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

protein import into nucleus

1 reference

14 February 2019

Latrunculin B or ATP depletion induces cofilin-dependent translocation of actin into nuclei of mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

cytoskeleton organization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

actin filament organization

ISS

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

negative regulation of cell adhesion

1 reference

14 February 2019

ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

positive regulation of lamellipodium assembly

1 reference

14 February 2019

Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

negative regulation of lamellipodium assembly

1 reference

14 February 2019

Non-overlapping activities of ADF and cofilin-1 during the migration of metastatic breast tumor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

response to organic cyclic compound

1 reference

14 February 2019

Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

1 reference

14 February 2019

Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

Cofilin Activation Is Temporally Associated with the Cessation of Growth in the Developing Hippocampus

IEP

hippocampus development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

regulation of cell morphogenesis

IEP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

establishment of cell polarity

ISS

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

cell projection organization

1 reference

14 February 2019

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

actin filament fragmentation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

positive regulation of cell growth

1 reference

14 February 2019

Non-overlapping activities of ADF and cofilin-1 during the migration of metastatic breast tumor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

negative regulation of actin filament depolymerization

1 reference

14 February 2019

Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

positive regulation of actin filament depolymerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

positive regulation of synaptic plasticity

1 reference

14 February 2019

Cofilin1 controls transcolumnar plasticity in dendritic spines in adult barrel cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

negative regulation of actin filament bundle assembly

1 reference

14 February 2019

Non-overlapping activities of ADF and cofilin-1 during the migration of metastatic breast tumor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

response to amino acid

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

negative regulation of cell size

1 reference

14 February 2019

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

positive regulation of proteolysis

1 reference

14 February 2019

Non-overlapping activities of ADF and cofilin-1 during the migration of metastatic breast tumor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

negative regulation of unidimensional cell growth

1 reference

14 February 2019

Non-overlapping activities of ADF and cofilin-1 during the migration of metastatic breast tumor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

positive regulation of focal adhesion assembly

1 reference

14 February 2019

Non-overlapping activities of ADF and cofilin-1 during the migration of metastatic breast tumor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

positive regulation of dendritic spine development

1 reference

14 February 2019

Cofilin1 controls transcolumnar plasticity in dendritic spines in adult barrel cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

regulation of dendritic spine morphogenesis

1 reference

14 February 2019

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

cellular response to hydrogen peroxide

ISS

1 reference

14 February 2019

SPIN90 dephosphorylation is required for cofilin-mediated actin depolymerization in NMDA-stimulated hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

cellular response to interleukin-1

1 reference

14 February 2019

Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

cellular response to interleukin-6

1 reference

14 February 2019

Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

cellular response to tumor necrosis factor

1 reference

14 February 2019

Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

cellular response to ether

1 reference

14 February 2019

Decabrominated diphenyl ether (BDE-209) and/or BDE-47 exposure alters protein expression in purified neural stem/progenitor cells determined by proteomics analysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

negative regulation of dendritic spine maintenance

IEP

positive regulation of NMDA glutamate receptor activity

NAS

1 reference

14 February 2019

Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

positive regulation of protein localization to cell leading edge

1 reference

14 February 2019

Chronophin coordinates cell leading edge dynamics by controlling active cofilin levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

negative regulation of postsynaptic density organization

1 reference

14 February 2019

ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

cellular response to insulin-like growth factor stimulus

1 reference

14 February 2019

Identification of Bax-interacting proteins in oligodendrocyte progenitors during glutamate excitotoxicity and perinatal hypoxia-ischemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

negative regulation of cell motility

1 reference

14 February 2019

Non-overlapping activities of ADF and cofilin-1 during the migration of metastatic breast tumor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

positive regulation of cell motility

1 reference

14 February 2019

O-GlcNAcylation of cofilin promotes breast cancer cell invasion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

positive regulation of establishment of cell polarity regulating cell shape

1 reference

14 February 2019

ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

positive regulation of barbed-end actin filament capping

1 reference

14 February 2019

Spatial regulation of RhoC activity defines protrusion formation in migrating cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45592

Actin-depolymerising factor homology domain

has part(s)

1 reference

stated in

InterPro Release 71.0