Serpin family E member 1 (Q28561352)

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mammalian protein found in Rattus norvegicus

Serpine1
endothelial plasminogen activator inhibitor
serine (or cysteine) proteinase inhibitor, clade E, member 1
serpin E1
PAI
PAI-1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
serine (or cysteine) proteinase inhibitor, member 1
serine (or cysteine) peptidase inhibitor, clade E, member 1
plasminogen activator inhibitor 1
serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Language	Label	Description	Also known as
English	Serpin family E member 1	mammalian protein found in Rattus norvegicus	Serpine1 endothelial plasminogen activator inhibitor serine (or cysteine) proteinase inhibitor, clade E, member 1 serpin E1 PAI PAI-1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 serine (or cysteine) proteinase inhibitor, member 1 serine (or cysteine) peptidase inhibitor, clade E, member 1 plasminogen activator inhibitor 1 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Serpin superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20961

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20961

Serpin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serpin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protease binding

determination method

1 reference

14 February 2019

Characterization of recombinant rat plasminogen activator inhibitor-1 and development of immunological tools for its quantitation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

serine-type endopeptidase inhibitor activity

determination method

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

14 February 2019

Characterization of recombinant rat plasminogen activator inhibitor-1 and development of immunological tools for its quantitation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

peptidase inhibitor activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

extracellular region

determination method

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

14 February 2019

Dual role for plasminogen activator inhibitor type 1 as soluble and as matricellular regulator of epithelial alveolar cell wound healing

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

14 February 2019

Plasminogen enhances the secretion of plasminogen activator inhibitor-1 from cultured rat astrocytes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

extracellular space

determination method

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

14 February 2019

Establishment of a peritoneal mesothelial cell line from a transgenic rat harbouring the temperature-sensitive simian virus 40 large T-antigen gene

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

determination method

1 reference

14 February 2019

Effects of Kaixinjieyu, a Chinese herbal medicine preparation, on neurovascular unit dysfunction in rats with vascular depression

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

chromaffin granule

determination method

1 reference

14 February 2019

The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

biological process

response to reactive oxygen species

determination method

1 reference

14 February 2019

Reactive oxygen species modulate HIF-1 mediated PAI-1 expression: involvement of the GTPase Rac1

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

female gonad development

determination method

1 reference

14 February 2019

Studies on the role of plasminogen activators and plasminogen activator inhibitor type-1 in rat corpus luteum of pregnancy

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

negative regulation of peptidase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

positive regulation of gene expression

determination method

1 reference

14 February 2019

siRNA against plasminogen activator inhibitor-1 ameliorates bleomycin-induced lung fibrosis in rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

negative regulation of gene expression

determination method

1 reference

14 February 2019

siRNA against plasminogen activator inhibitor-1 ameliorates bleomycin-induced lung fibrosis in rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

negative regulation of endopeptidase activity

determination method

3 references

14 February 2019

Plasminogen enhances the secretion of plasminogen activator inhibitor-1 from cultured rat astrocytes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

14 February 2019

Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

negative regulation of cell migration

determination method

response to nutrient levels

determination method

1 reference

14 February 2019

Elevated urinary urea by high-protein diet could be one of the inducements of bladder disorders

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

response to lipopolysaccharide

determination method

1 reference

14 February 2019

Monoclonal antibody-based immunoassays for the specific quantitation of rat PAI-1 antigen and activity in biological samples

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to insulin stimulus

determination method

1 reference

14 February 2019

Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

positive regulation of collagen biosynthetic process

determination method

1 reference

14 February 2019

Effects of glucose and plasminogen activator inhibitor-1 on collagen metabolism in the peritoneum

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

response to cytokine

determination method

1 reference

14 February 2019

Establishment of a peritoneal mesothelial cell line from a transgenic rat harbouring the temperature-sensitive simian virus 40 large T-antigen gene

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

response to laminar fluid shear stress

determination method

1 reference

14 February 2019

Shear stress induces hepatocyte PAI-1 gene expression through cooperative Sp1/Ets-1 activation of transcription

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to potassium ion

determination method

1 reference

14 February 2019

The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to platelet-derived growth factor stimulus

determination method

1 reference

14 February 2019

Regulation of proteolytic enzymes and inhibitors in two smooth muscle cell phenotypes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

tissue regeneration

determination method

1 reference

14 February 2019

The induction of the immediate-early-genes Egr-1, PAI-1 and PRL-1 during liver regeneration in surgical models is related to increased portal flow

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

glucose homeostasis

determination method

1 reference

14 February 2019

The hexosamine pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-beta I and -delta

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

response to starvation

determination method

1 reference

14 February 2019

CREB binding to the hypoxia-inducible factor-1 responsive elements in the plasminogen activator inhibitor-1 promoter mediates the glucagon effect

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

response to estrogen

determination method

1 reference

14 February 2019

Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to fibroblast growth factor stimulus

determination method

1 reference

14 February 2019

Regulation of proteolytic enzymes and inhibitors in two smooth muscle cell phenotypes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

mast cell activation

determination method

1 reference

14 February 2019

Transcriptional regulation of plasminogen activator inhibitor-1 by transforming growth factor-beta, activin A and microphthalmia-associated transcription factor

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

decidualization

determination method

1 reference

14 February 2019

Presence of urokinase plasminogen activator and plasminogen activator inhibitor-1 messenger ribonucleic acids in rat endometrium during decidualization in vivo

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

positive regulation of fibroblast proliferation

determination method

1 reference

14 February 2019

siRNA against plasminogen activator inhibitor-1 ameliorates bleomycin-induced lung fibrosis in rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

positive regulation of receptor-mediated endocytosis

determination method

1 reference

14 February 2019

Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

positive regulation of coagulation

determination method

1 reference

14 February 2019

Inhibition of plasminogen activator inhibitor-1: its mechanism and effectiveness on coagulation and fibrosis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

positive regulation of keratinocyte migration

determination method

1 reference

14 February 2019

PAI-1 expression is required for epithelial cell migration in two distinct phases of in vitro wound repair

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

response to hyperoxia

determination method

1 reference

14 February 2019

Changes of u-PA and PAI-1 expression in the lung tissue of neonatal rats after inhaling high concentration oxygen

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to hydrogen peroxide

determination method

1 reference

14 February 2019

Glucose upregulates plasminogen activator inhibitor-1 gene expression in vascular smooth muscle cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

response to epidermal growth factor

determination method

1 reference

14 February 2019

The EGF-inducible protein EIP-1 of migrating normal and malignant rat liver epithelial cells is identical to plasminogen activator inhibitor 1 and is a component of the ECM migration tracks

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to lipopolysaccharide

determination method

1 reference

14 February 2019

Potentiating effect of endothelial cells on astrocytic plasminogen activator inhibitor type-1 gene expression in an in vitro model of the blood-brain barrier

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to metal ion

determination method

1 reference

14 February 2019

The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to gravity

determination method

1 reference

14 February 2019

Plasminogen activator inhibitor type 1 up-regulation is associated with skeletal muscle atrophy and associated fibrosis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to mechanical stimulus

determination method

1 reference

14 February 2019

Cyclic stretch magnitude and duration affect rat alveolar epithelial gene expression

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to nicotine

determination method

1 reference

14 February 2019

The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to ATP

determination method

1 reference

14 February 2019

P2Y receptor regulation of PAI-1 expression in vascular smooth muscle cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to cAMP

determination method

1 reference

14 February 2019

Cyclic nucleotide regulation of type-1 plasminogen activator-inhibitor mRNA stability in rat hepatoma cells. Identification of cis-acting sequences

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to cGMP

determination method

1 reference

14 February 2019

Natriuretic factors and nitric oxide suppress plasminogen activator inhibitor-1 expression in vascular smooth muscle cells. Role of cGMP in the regulation of the plasminogen system

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to interleukin-1

determination method

1 reference

14 February 2019

Interleukin-1-mediated regulation of plasminogen activation in pregnant mare serum gonadotropin-primed rat granulosa cells is independent of prostaglandin production

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to growth factor stimulus

determination method

1 reference

14 February 2019

Glucocorticoids activate TGF-beta induced PAI-1 and CTGF expression in rat hepatocytes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to follicle-stimulating hormone stimulus

determination method

1 reference

14 February 2019

Plasminogen activator inhibitor-1 is expressed in cultured rat Sertoli cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to glucagon stimulus

determination method

1 reference

14 February 2019

CREB binding to the hypoxia-inducible factor-1 responsive elements in the plasminogen activator inhibitor-1 promoter mediates the glucagon effect

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to low-density lipoprotein particle stimulus

determination method

1 reference

14 February 2019

In vivo stimulation of vascular plasminogen activator inhibitor-1 production by very low-density lipoprotein involves transcription factor binding to a VLDL-responsive element

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to organic cyclic compound

determination method

cellular response to cycloheximide

determination method

1 reference

14 February 2019

Regulation of plasminogen activator inhibitor-1 mRNA accumulation by basic fibroblast growth factor and transforming growth factor-beta1 in cultured rat astrocytes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to hypoxia

determination method

1 reference

14 February 2019

Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to dexamethasone stimulus

determination method

1 reference

14 February 2019

The EGF-inducible protein EIP-1 of migrating normal and malignant rat liver epithelial cells is identical to plasminogen activator inhibitor 1 and is a component of the ECM migration tracks

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

response to transforming growth factor beta

determination method

1 reference

14 February 2019

MAPK/AP-1-dependent regulation of PAI-1 gene expression by TGF-beta in rat mesangial cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to transforming growth factor beta stimulus

determination method

1 reference

14 February 2019

Modulation of retinal capillary endothelial cells by Müller glial cell-derived factors

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

positive regulation of calcium ion import

determination method

1 reference

14 February 2019

siRNA against plasminogen activator inhibitor-1 ameliorates bleomycin-induced lung fibrosis in rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

replicative senescence

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to aldosterone

determination method

1 reference

14 February 2019

Aldosterone and TGF-β₁ synergistically increase PAI-1 expression in hepatic stellate cells of rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to angiotensin

determination method

1 reference

14 February 2019

Salvia miltiorrhiza depresses plasminogen activator inhibitor-1 production through inhibition of angiotensin II.

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to resveratrol

determination method

1 reference

14 February 2019

Resveratrol inhibits inflammation and ameliorates insulin resistant endothelial dysfunction via regulation of AMP-activated protein kinase and sirtuin 1 activities

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

positive regulation of epithelium regeneration

determination method

1 reference

14 February 2019

Dual role for plasminogen activator inhibitor type 1 as soluble and as matricellular regulator of epithelial alveolar cell wound healing

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to nerve growth factor stimulus

determination method

1 reference

14 February 2019

The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

cellular response to leukemia inhibitory factor

determination method

1 reference

14 February 2019

Osteoblasts display receptors for and responses to leukemia-inhibitory factor

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961

determination method

Serpin, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20961

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20961

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSRNOP00000001916

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000001916

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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