N-acylsphingosine amidohydrolase 2 (Q28561375)

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mammalian protein found in Rattus norvegicus

neutral ceramidase
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
neutral/alkaline ceramidase
NCDase
acylsphingosine deacylase 2
Asah2

Language	Label	Description	Also known as
English	N-acylsphingosine amidohydrolase 2	mammalian protein found in Rattus norvegicus	neutral ceramidase N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 neutral/alkaline ceramidase NCDase acylsphingosine deacylase 2 Asah2

Statements

1 reference

25 May 2022

UniProt protein ID

Neutral/alkaline nonlysosomal ceramidase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q91XT9

Neutral ceramidase, C-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q91XT9

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Neutral/alkaline non-lysosomal ceramidase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Neutral/alkaline non-lysosomal ceramidase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

calcium ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

zinc ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

hydrolase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

N-acylsphingosine amidohydrolase activity

determination method

4 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91XT9&geneProductId=UniProtKB:Q91XT9

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91XT9&geneProductId=UniProtKB:Q91XT9

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91XT9&geneProductId=UniProtKB:Q91XT9

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91XT9&geneProductId=UniProtKB:Q91XT9

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

ceramidase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

N-acylsphingosine amidohydrolase activity

determination method

9 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

9 May 2019

Conserved amino acid residues in the COOH-terminal tail are indispensable for the correct folding and localization and enzyme activity of neutral ceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

9 May 2019

Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

9 May 2019

Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

9 May 2019

Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

9 May 2019

Rat intestinal ceramidase: purification, properties, and physiological relevance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

phytoceramidase activity

determination method

1 reference

9 May 2019

Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

dihydroceramidase activity

determination method

1 reference

9 May 2019

Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

extracellular region

determination method

1 reference

14 January 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91XT9&geneProductId=UniProtKB:Q91XT9

determination method

plasma membrane

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91XT9&geneProductId=UniProtKB:Q91XT9

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

integral component of membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

extracellular space

determination method

3 references

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

14 February 2019

O-glycosylation of mucin-like domain retains the neutral ceramidase on the plasma membranes as a type II integral membrane protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

14 February 2019

Conserved amino acid residues in the COOH-terminal tail are indispensable for the correct folding and localization and enzyme activity of neutral ceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

determination method

2 references

Golgi apparatus

determination method

1 reference

14 January 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91XT9&geneProductId=UniProtKB:Q91XT9

determination method

integral component of plasma membrane

determination method

3 references

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

14 February 2019

O-glycosylation of mucin-like domain retains the neutral ceramidase on the plasma membranes as a type II integral membrane protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

14 February 2019

Conserved amino acid residues in the COOH-terminal tail are indispensable for the correct folding and localization and enzyme activity of neutral ceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

determination method

1 reference

14 January 2019

Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91XT9&geneProductId=UniProtKB:Q91XT9

determination method

extracellular exosome

determination method

1 reference

14 January 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91XT9&geneProductId=UniProtKB:Q91XT9

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

extracellular space

determination method

integral component of plasma membrane

determination method

biological process

lipid metabolism

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

sphingolipid metabolic process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

sphingosine metabolic process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

ceramide metabolic process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

apoptotic process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

response to organic substance

determination method

1 reference

9 May 2019

Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

long-chain fatty acid biosynthetic process

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

sphingosine biosynthetic process

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91XT9&geneProductId=UniProtKB:Q91XT9

determination method

ceramide catabolic process

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91XT9&geneProductId=UniProtKB:Q91XT9

determination method

regulation of mitotic cell cycle

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

lipid digestion

determination method

2 references

sphingosine biosynthetic process

determination method

5 references

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

14 February 2019

Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

14 February 2019

Rat intestinal ceramidase: purification, properties, and physiological relevance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

14 February 2019

Conserved amino acid residues in the COOH-terminal tail are indispensable for the correct folding and localization and enzyme activity of neutral ceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

ceramide biosynthetic process

determination method

3 references

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

14 February 2019

Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

14 February 2019

Conserved amino acid residues in the COOH-terminal tail are indispensable for the correct folding and localization and enzyme activity of neutral ceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

ceramide catabolic process

determination method

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

9 May 2019

Conserved amino acid residues in the COOH-terminal tail are indispensable for the correct folding and localization and enzyme activity of neutral ceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

9 May 2019

Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

9 May 2019

Rat intestinal ceramidase: purification, properties, and physiological relevance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

negative regulation of apoptotic signaling pathway

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

lipid digestion

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

sphingosine biosynthetic process

determination method

4 references

9 May 2019

Conserved amino acid residues in the COOH-terminal tail are indispensable for the correct folding and localization and enzyme activity of neutral ceramidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

9 May 2019

Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

9 May 2019

Rat intestinal ceramidase: purification, properties, and physiological relevance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XT9

determination method

ceramide biosynthetic process

determination method

2 references

Neutral/alkaline non-lysosomal ceramidase, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q91XT9

Neutral/alkaline non-lysosomal ceramidase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q91XT9

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSRNOP00000016688

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000016688

ENSRNOP00000073116

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000073116

Sitelinks

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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