Interleukin 18 (Q28562618)

interleukin-18 receptor binding

IPI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

14 February 2019

Interleukin-18 is expressed in rat testis and may promote germ cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

14 February 2019

IL-18 overexpression promotes vascular inflammation and remodeling in a rat model of metabolic syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

1 reference

14 February 2019

Up-regulation of IL-18 and IL-12 in the ileum of neonatal rats with necrotizing enterocolitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

Up-regulation of IL-18 and IL-12 in the ileum of neonatal rats with necrotizing enterocolitis

apical plasma membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

1 reference

14 February 2019

Evidence of IL-18 as a novel angiogenic mediator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

osteoblast differentiation

1 reference

14 February 2019

Interleukin-18 is regulated by parathyroid hormone and is required for its bone anabolic actions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

1 reference

14 February 2019

Interleukin-18 involvement in hypoxic-ischemic brain injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

inflammatory response

2 references

1 reference

14 February 2019

1 reference

14 February 2019

Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

Shock wave therapy effectively attenuates inflammation in rat carotid artery following endothelial denudation by balloon catheter

TAS

response to radiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

1 reference

14 February 2019

Induction of interferon-gamma inducing factor in the adrenal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

regulation of signaling receptor activity

1 reference

14 February 2019

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of smooth muscle cell migration

IEA

1 reference

14 February 2019

Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

regulation of cell adhesion

1 reference

14 February 2019

A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

1 reference

14 February 2019

Global and gene-specific translational regulation in rat lung development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of chemokine production

1 reference

14 February 2019

Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O2- production and intestinal edema following alcohol intoxication and burn injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of interferon-gamma production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of interleukin-1 beta production

1 reference

14 February 2019

The effects of interleukin-18 on rat articular chondrocytes: a study of mRNA expression and protein synthesis of proinflammatory substances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of interleukin-8 production

1 reference

14 February 2019

Constitutive expression of IL-18 and IL-18R in differentiated IEC-6 cells: effect of TNF-alpha and IFN-gamma treatment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of tumor necrosis factor production

1 reference

14 February 2019

The effects of interleukin-18 on rat articular chondrocytes: a study of mRNA expression and protein synthesis of proinflammatory substances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of superoxide anion generation

1 reference

14 February 2019

Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O2- production and intestinal edema following alcohol intoxication and burn injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of collagen biosynthetic process

1 reference

14 February 2019

Overexpression of interleukin-18 aggravates cardiac fibrosis and diastolic dysfunction in fructose-fed rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

negative regulation of neutrophil apoptotic process

1 reference

14 February 2019

Interleukin-18 Delays Neutrophil Apoptosis following Alcohol Intoxication and Burn Injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

interleukin-18-mediated signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

T-helper 1 type immune response

1 reference

14 February 2019

Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of activated T cell proliferation

1 reference

14 February 2019

Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of apoptotic process

1 reference

14 February 2019

Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of vascular permeability

1 reference

14 February 2019

Role of IL-18 in acute lung inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

response to peptide hormone

1 reference

14 February 2019

Tissue-specific expression of rat IL-18 gene and response to adrenocorticotropic hormone treatment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of neuron apoptotic process

1 reference

14 February 2019

Activation of caspase-1 dependent interleukins in developmental brain trauma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

regulation of circadian sleep/wake cycle, non-REM sleep

1 reference

14 February 2019

Interleukin-18 promotes sleep in rabbits and rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

digestive tract morphogenesis

TAS

1 reference

14 February 2019

Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of smooth muscle cell proliferation

1 reference

14 February 2019

Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

negative regulation of peptidyl-tyrosine phosphorylation

1 reference

14 February 2019

Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

detection of mechanical stimulus involved in sensory perception of pain

1 reference

14 February 2019

The NALP1 inflammasome controls cytokine production and nociception in a rat fracture model of complex regional pain syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of NF-kappaB transcription factor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

Erythropoietin attenuates hyperoxia-induced cell death by modulation of inflammatory mediators and matrix metalloproteinases

response to hyperoxia

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

cellular response to hydrogen peroxide

1 reference

14 February 2019

TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in cardiomyocytes via NF-kappa B activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

cellular response to lipopolysaccharide

1 reference

14 February 2019

Role of IL-18 in acute lung inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

cellular response to mechanical stimulus

1 reference

14 February 2019

Mechanical stretch induced interleukin-18 (IL-18) expression through Angiotensin subtype 1 receptor (AT1R) and endothelin-1 in cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

cellular response to cAMP

1 reference

14 February 2019

Thyroid-stimulating hormone induces interleukin-18 gene expression in FRTL-5 cells: immunohistochemical detection of interleukin-18 in autoimmune thyroid disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

cellular response to interferon-gamma

1 reference

14 February 2019

Constitutive expression of IL-18 and IL-18R in differentiated IEC-6 cells: effect of TNF-alpha and IFN-gamma treatment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

cellular response to tumor necrosis factor

1 reference

14 February 2019

Constitutive expression of IL-18 and IL-18R in differentiated IEC-6 cells: effect of TNF-alpha and IFN-gamma treatment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

cellular response to parathyroid hormone stimulus

1 reference

14 February 2019

Interleukin-18 is regulated by parathyroid hormone and is required for its bone anabolic actions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

cellular response to peptide hormone stimulus

1 reference

14 February 2019

Thyroid-stimulating hormone induces interleukin-18 gene expression in FRTL-5 cells: immunohistochemical detection of interleukin-18 in autoimmune thyroid disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of cold-induced thermogenesis

1 reference

14 February 2019

Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of male germ cell proliferation

1 reference

14 February 2019

Interleukin-18 is expressed in rat testis and may promote germ cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of blood vessel remodeling

1 reference

14 February 2019

IL-18 overexpression promotes vascular inflammation and remodeling in a rat model of metabolic syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636

positive regulation of T-helper 1 cell cytokine production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636