Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier (Q28565021)

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English	Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier	scientific journal article

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scholarly article

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31 January 2017

Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier (English)

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31 January 2017

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blood–brain barrier

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based on heuristic

inferred from title

David S. Miller

6

object named as

David S. Miller

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31 January 2017

author name string

Björn Bauer

1

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31 January 2017

Anika M. S. Hartz

2

1 reference

31 January 2017

Jonathan R. Lucking

3

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31 January 2017

Xiaodong Yang

4

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31 January 2017

Gary M. Pollack

5

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31 January 2017

publication date

1 June 2008

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31 January 2017

Journal of Cerebral Blood Flow & Metabolism

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31 January 2017

28

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31 January 2017

6

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31 January 2017

1222–1234

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31 January 2017

Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier.

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In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation.

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Contribution of glial cells and pericytes to the mRNA profiles of P-glycoprotein and multidrug resistance-associated proteins in an in vitro model of the blood-brain barrier.

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Drug metabolizing enzyme activities and superoxide formation in primary and immortalized rat brain endothelial cells

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Dexamethasone modulation of multidrug transporters in normal tissues.

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Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects.

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Nuclear receptors and the control of metabolism

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Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

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Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene

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Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1.

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Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide.

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The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage

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Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats.

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Expression of rat Multidrug Resistance Protein 2 (Mrp2) in male and female rats during normal and pregnenolone-16alpha-carbonitrile (PCN)-induced postnatal ontogeny

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The role of protein synthesis and degradation in the post-transcriptional regulation of rat multidrug resistance-associated protein 2 (Mrp2, Abcc2)

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Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

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The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

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The MRP family of drug efflux pumps

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Regulation of drug and bile salt transporters in liver and intestine

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Mrp4 confers resistance to topotecan and protects the brain from chemotherapy

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Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense

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Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a tri-glutathione conjugate is required

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Drug resistance in brain diseases and the role of drug efflux transporters.

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Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

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Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

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Xenobiotic efflux pumps in isolated fish brain capillaries

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Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators

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Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor

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Molecular aspects of renal anionic drug transport

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Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers.

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Role of Multidrug Resistance Protein 2 (MRP2, ABCC2) in Alkylating Agent Detoxification: MRP2 Potentiates GlutathioneS-Transferase A1-1-Mediated Resistance to Chlorambucil Cytotoxicity

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Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes.

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Identifiers

10.1038/JCBFM.2008.16

1 reference

31 January 2017

1 reference

31 January 2017

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