Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension (Q28566149)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16205723%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

title

Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension (English)

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16205723%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

main subject

arterial hypertension

1 reference

based on heuristic

inferred from title

pulmonary hypertension

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16205723%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Gervaise Loirand

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16205723%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

author name string

Vincent Sauzeau

2

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16205723%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Malvyne Rolli-Derkinderen

3

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16205723%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Patrice Guérin

4

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16205723%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Christine Sagan

5

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16205723%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Pierre Pacaud

6

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16205723%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

language of work or name

English

0 references

publication date

1 December 2005

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16205723%20AND%20SRC:MED&resulttype=core&format=json

British Journal of Pharmacology

7 January 2020

published in

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16205723%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

volume

146

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16205723%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

issue

7

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16205723%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

page(s)

1010-1018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16205723%20AND%20SRC:MED&resulttype=core&format=json

Pleiotropic effects of statins

7 January 2020

cites work

1 reference

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Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension

19 March 2017

1 reference

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Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase

19 March 2017

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Phosphorylation states of Cdc42 and RhoA regulate their interactions with Rho GDP dissociation inhibitor and their extraction from biological membranes

19 March 2017

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Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle

19 March 2017

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Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase

19 March 2017

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Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase

19 March 2017

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Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

7 April 2017

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Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension.

7 April 2017

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Endothelial dysfunction in pulmonary hypertension

29 September 2017

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cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions

29 September 2017

1 reference

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Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

29 September 2017

1 reference

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cGMP-dependent protein kinase phosphorylates and inactivates RhoA.

29 September 2017

1 reference

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Smooth muscle differentiation marker gene expression is regulated by RhoA-mediated actin polymerization

29 September 2017

1 reference

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Role of nitric oxide in the pathogenesis of chronic pulmonary hypertension

29 September 2017

1 reference

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Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II.

29 September 2017

1 reference

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Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes

29 September 2017

1 reference

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Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF.

29 September 2017

1 reference

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Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats

29 September 2017

1 reference

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Serine phosphorylation negatively regulates RhoA in vivo.

3 June 2018

1 reference

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RhoA expression is controlled by nitric oxide through cGMP-dependent protein kinase activation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Sildenafil inhibits hypoxia-induced pulmonary hypertension

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Pulmonary hypertension: updating a mysterious disease

3 June 2018

1 reference

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Preparation of extracts from higher eukaryotes

3 June 2018

1 reference

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Simultaneous localization and quantification of relative G and F actin content: optimization of fluorescence labeling methods

3 June 2018

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Attenuation of chronic hypoxic pulmonary hypertension by simvastatin

3 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJP.0706408

Rho-kinase activation is involved in hypoxia-induced pulmonary vasoconstriction

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJP.0706408

Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension: a time for reappraisal?

21 January 2018

1 reference

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Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Chronic hypoxia augments protein kinase G-mediated Ca2+ desensitization in pulmonary vascular smooth muscle through inhibition of RhoA/Rho kinase signaling

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

A combination of oral sildenafil and beraprost ameliorates pulmonary hypertension in rats

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Sildenafil prevents change in RhoA expression induced by chronic hypoxia in rat pulmonary artery.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertension

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Endothelin-1 is elevated in monocrotaline pulmonary hypertension.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: changes in pulmonary hypertension

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751229

Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16205723

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Primary pulmonary hypertension

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16205723

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.BJP.0706408

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16205723%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16205723%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

2 references