Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cells (Q28567838)

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English	Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cells	scientific journal article

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scholarly article

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PubMed publication ID

31 January 2017

Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cells (English)

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PubMed publication ID

31 January 2017

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author name string

J. L. Mazet

1

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31 January 2017

M. Padieu

2

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31 January 2017

H. Osman

3

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31 January 2017

G. Maume

4

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31 January 2017

P. Mailliet

5

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31 January 2017

N. Dereu

6

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31 January 2017

A. D. Hamilton

7

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31 January 2017

F. Lavelle

8

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31 January 2017

S. M. Sebti

9

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31 January 2017

B. F. Maume

10

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31 January 2017

language of work or name

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publication date

29 October 1999

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31 January 2017

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31 January 2017

460

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31 January 2017

2

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31 January 2017

235–240

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31 January 2017

Protein prenylation: molecular mechanisms and functional consequences

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Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation

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The ras gene family and human carcinogenesis

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Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

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Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

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Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

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21 January 2018

Geranylgeranyl as well as farnesyl moiety is transferred to Ras p21 overproduced in adrenocortical cells transformed by c-Ha-rasEJ oncogene.

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21 January 2018

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

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21 January 2018

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

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21 January 2018

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

1 reference

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Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation

1 reference

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Aldosterone biosynthesis induced by ACTH and angiotensin II in newborn rat adrenocortical cells transfected by c-EJ-Ha-ras oncogene

1 reference

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21 January 2018

Specific labeling of isoprenylated proteins: application to study inhibitors of the post-translational farnesylation and geranylgeranylation

1 reference

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A Detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis

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Mechanism of activation of a human oncogene

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A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

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Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

1 reference

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21 January 2018

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

1 reference

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21 January 2018

A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity

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Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: interactive binding between substrates and a preferred kinetic pathway.

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Differential prenyl pyrophosphate binding to mammalian protein geranylgeranyltransferase-I and protein farnesyltransferase and its consequence on the specificity of protein prenylation

1 reference

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The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity

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Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution

1 reference

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Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I

1 reference

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7 January 2021

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10.1016/S0014-5793(99)01355-1

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31 January 2017

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