Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus kinase-2 (JAK2)/signal transducer and activator of transcription-5 (STAT5) signalling (Q28571937)

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English	Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus kinase-2 (JAK2)/signal transducer and activator of transcription-5 (STAT5) signalling	scientific journal article

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scholarly article

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31 January 2017

Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus kinase-2 (JAK2)/signal transducer and activator of transcription-5 (STAT5) signalling (English)

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31 January 2017

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author name string

N. Guthalu Kondegowda

1

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31 January 2017

A. Mozar

2

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31 January 2017

C. Chin

3

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31 January 2017

A. Otero

4

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31 January 2017

A. Garcia-Ocaña

5

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31 January 2017

R. C. Vasavada

6

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31 January 2017

publication date

1 June 2012

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31 January 2017

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31 January 2017

55

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31 January 2017

6

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31 January 2017

1721–1732

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31 January 2017

https://scigraph.springernature.com/pub.10.1007/s00125-012-2501-9

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Type 2 diabetes across generations: from pathophysiology to prevention and management

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes

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https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

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https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Islet beta cell failure in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Nutritionally induced insulin resistance and receptor defect leading to beta-cell failure in animal models

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development

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https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance

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https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Prolactin receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancy

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https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Growth factors and beta cell replication.

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https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Characterization of mice doubly transgenic for parathyroid hormone-related protein and murine placental lactogen: a novel role for placental lactogen in pancreatic beta-cell survival.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation

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https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Recombinant human prolactin promotes human beta cell survival via inhibition of extrinsic and intrinsic apoptosis pathways.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Prolactin supplementation to culture medium improves beta-cell survival.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Protein kinase C-zeta activation markedly enhances beta-cell proliferation: an essential role in growth factor mediated beta-cell mitogenesis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Naturally occurring dominant-negative Stat5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Effects of sex and pregnancy hormones on growth hormone and prolactin receptor gene expression in insulin-producing cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

JAK/STAT signal transduction: regulators and implication in hematological malignancies

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Erythropoietin can induce the expression of bcl-x(L) through Stat5 in erythropoietin-dependent progenitor cell lines

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Bcl-2 proteins and mitochondria--specificity in membrane targeting for death

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Glucocorticoid-induced apoptosis in human eosinophils: mechanisms of action

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Declining insulin requirement in the late first trimester of diabetic pregnancy

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

Pregnancy-induced rise in serum C-peptide concentrations in women with type 1 diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2501-9

21 January 2018

The role of Stat5 transcription factors as tumor suppressors or oncogenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic oxidative stress as a mechanism for glucose toxicity of the beta cell in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dexamethasone counteracts the effect of prolactin on islet function: implications for islet regulation in late pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Residual B-cell function and glycaemic control in diabetic pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolactin receptors and JAK2 in islets of Langerhans: an immunohistochemical analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. III. Effect of H-2 haplotype and sex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and regulation of secretion of mouse placental lactogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STAT5 activity in pancreatic beta-cells influences the severity of diabetes in animal models of type 1 and 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22382519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1007/S00125-012-2501-9

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31 January 2017

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31 January 2017

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