Addicting drugs utilize a synergistic molecular mechanism in common requiring adenosine and Gi-βγ dimers (Q28578407)

https://api.crossref.org/works/10.1073/PNAS.2336093100

30 March 2024

author name string

Lina Yao

1

1 reference

31 January 2017

Peidong Fan

2

1 reference

31 January 2017

Zhan Jiang

3

1 reference

31 January 2017

William S. Mailliard

4

1 reference

31 January 2017

Adrienne S. Gordon

5

1 reference

31 January 2017

Ivan Diamond

6

1 reference

31 January 2017

language of work or name

English

0 references

publication date

25 November 2003

1 reference

31 January 2017

6 November 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14605213

full work available at URL

30 March 2024

https://www.pnas.org/content/pnas/100/24/14379.full.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14605213

https://europepmc.org/articles/PMC283600

30 March 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14605213

https://europepmc.org/articles/PMC283600?pdf=render

30 March 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14605213

https://doi.org/10.1073/pnas.2336093100

30 March 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14605213

https://pnas.org/doi/pdf/10.1073/pnas.2336093100

30 March 2024

1 reference

https://api.crossref.org/works/10.1073/PNAS.2336093100

Proceedings of the National Academy of Sciences of the United States of America

30 March 2024

published in

1 reference

31 January 2017

100

1 reference

31 January 2017

24

1 reference

31 January 2017

14379–14384

1 reference

31 January 2017

betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

The many dimensions of cAMP signaling

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Addiction and the brain: The neurobiology of compulsion and its persistence

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Molecular basis of long-term plasticity underlying addiction

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Characterization of the analgesic actions of adenosine: comparison of adenosine and remifentanil infusions in patients undergoing major surgical procedures

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Cannabinoid addiction: behavioral models and neural correlates.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Neural systems underlying opiate addiction.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Ethanol stimulates cAMP-responsive element (CRE)-mediated transcription via CRE-binding protein and cAMP-dependent protein kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

G protein specificity: traffic direction required.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Distribution, biochemistry and function of striatal adenosine A2A receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Activation of type II adenylate cyclase by D2 and D4 but not D3 dopamine receptors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Ethanol regulation of adenosine receptor-stimulated cAMP levels in a clonal neural cell line: an in vitro model of cellular tolerance to ethanol

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

The role of dopaminergic systems in opioid receptor desensitization in nucleus accumbens and caudate putamen of rat after chronic morphine treatment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Tailoring cAMP-signalling responses through isoform multiplicity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Localization of delta opioid receptor immunoreactivity in interneurons and pyramidal cells in the rat hippocampus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Bromocriptine self-administration and bromocriptine-reinstatement of cocaine-trained and heroin-trained lever pressing in rats

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Ethanol increases extracellular adenosine by inhibiting adenosine uptake via the nucleoside transporter.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Drug addiction: bad habits add up.

3 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2336093100

Protein kinase C-epsilon is necessary for erythropoietin's up-regulation of c-myc and for factor-dependent DNA synthesis. Evidence for discrete signals for growth and differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2336093100

The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2336093100

Mediation by G protein betagamma subunits of the opioid stimulation of adenylyl cyclase activity in rat olfactory bulb

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2336093100

Mu-opioid agonist enhancement of prostaglandin-induced hyperalgesia in the rat: a G-protein beta gamma subunit-mediated effect?

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2336093100

Anandamide: a candidate neurotransmitter heads for the big leagues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2336093100

Adenosine A(2) receptors inhibit morphine self-administration in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2336093100

Modulation of adenosine concentration by opioid receptor agonists in rat striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2336093100

Withdrawal and bidirectional cross-withdrawal responses in rats treated with adenosine agonists and morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2336093100

Failure of intravenous morphine to serve as an effective instrumental reinforcer in dopamine D2 receptor knock-out mice.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Long-lasting potentiation of GABAergic synapses in dopamine neurons after a single in vivo ethanol exposure.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Increase in adenosine sensitivity in the nucleus accumbens following chronic morphine treatment

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

D(2), but not D(1) dopamine receptor agonists potentiate cannabinoid-induced sedation in nonhuman primates.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Dopamine-adenosine interactions in the striatum and the globus pallidus: inhibition of striatopallidal neurons through either D2 or A2A receptors enhances D1 receptor-mediated effects on c-fos expression.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283600

Distribution of D2 dopamine receptor mRNA in the primate brain

27 November 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2336093100

Central adenosine A(2A) receptors: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2336093100

Adenosine receptor antagonists inhibit the development of morphine sensitization in the C57BL/6 mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2336093100

Gbeta subunit interacts with a peptide encoding region 956-982 of adenylyl cyclase 2. Cross-linking of the peptide to free Gbetagamma but not the heterotrimer

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/14605213

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Differential involvement of D1 and D2 dopamine receptors in the expression of morphine withdrawal signs in rats

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/14605213

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Behavioural Pharmacology

28

7

448

1996

1 reference

https://api.crossref.org/works/10.1073/PNAS.2336093100

Journal of Pharmacology and Experimental Therapeutics

30 March 2024

35

292

952

2000

1 reference

https://api.crossref.org/works/10.1073/PNAS.2336093100

Journal of Pharmacology and Experimental Therapeutics

30 March 2024

39

283

557

1997

1 reference

https://api.crossref.org/works/10.1073/PNAS.2336093100

30 March 2024

Identifiers