Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane (Q28580739)

2

1 reference

31 January 2017

Javier Sanz

3

1 reference

31 January 2017

Karin Neubert

4

1 reference

31 January 2017

Reuven Stein

5

1 reference

31 January 2017

Christoph Borner

Structure of Bax: coregulation of dimer formation and intracellular localization

6

1 reference

31 January 2017

language of work or name

English

0 references

publication date

6 January 2003

1 reference

31 January 2017

Journal of Cell Biology

1 reference

31 January 2017

160

1 reference

31 January 2017

1

1 reference

31 January 2017

53–64

1 reference

31 January 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Bcl-2 and Bax function independently to regulate cell death

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Bcl-XL and Bcl-2 repress a common pathway of cell death

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

The targeting information of the mitochondrial outer membrane isoform of cytochrome b5 is contained within the carboxyl-terminal region

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

The Bcl2 family: regulators of the cellular life-or-death switch

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Protein import into mitochondria

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Delivery of nascent polypeptides to the mitochondrial surface

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Characterization of signal that directs C-tail-anchored proteins to mammalian mitochondrial outer membrane

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Bax and other pro-apoptotic Bcl-2 family "killer-proteins" and their victim the mitochondrion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Transient expression of wild-type or mitochondrially targeted Bcl-2 induces apoptosis, whereas transient expression of endoplasmic reticulum-targeted Bcl-2 is protective against Bax-induced cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Mitochondria as the central control point of apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

M11L: a novel mitochondria-localized protein of myxoma virus that blocks apoptosis of infected leukocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Bcl-xS and Bax induce different apoptotic pathways in PC12 cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Bcl-2 is a monomeric protein: prevention of homodimerization by structural constraints

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Targeting and insertion of nuclear-encoded preproteins into the mitochondrial outer membrane

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Targeting of tail-anchored proteins to yeast mitochondria in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Ca2+ homeostasis in the agonist-sensitive internal store: functional interactions between mitochondria and the ER measured In situ in intact cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

A signal-anchor sequence selective for the mitochondrial outer membrane

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Membrane topology of the Bcl-2 proto-oncogenic protein demonstrated in vitro.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Targeting of the master receptor MOM19 to mitochondria.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172731

Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage

3 June 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200210084

Characterization of the signal that directs Tom20 to the mitochondrial outer membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200210084

Targeting and insertion of C-terminally anchored proteins to the mitochondrial outer membrane is specific and saturable but does not strictly require ATP or molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200210084

Bcl-2 and porin follow different pathways of TOM-dependent insertion into the mitochondrial outer membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200210084

Mutants affecting the structure of the cortical endoplasmic reticulum in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200210084

Targeting of C-Terminal (Tail)-Anchored Proteins: Understanding how Cytoplasmic Activities are Anchored to Intracellular Membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200210084

The prevention of the staurosporine-induced apoptosis by Bcl-X(L), but not by Bcl-2 or caspase inhibitors, allows the extensive differentiation of human neuroblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200210084

Failure of Bcl-2 family members to interact with Apaf-1 in normal and apoptotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200210084

p75 Neurotrophin Receptor-mediated Neuronal Death Is Promoted by Bcl-2 and Prevented by Bcl-xL

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200210084

Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200210084

The malonyl-CoA-sensitive form of carnitine palmitoyltransferase is not localized exclusively in the outer membrane of rat liver mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200210084

Evidence for multiple mechanisms for membrane binding and integration via carboxyl-terminal insertion sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200210084

Charged amino acids at the carboxyl-terminal portions determine the intracellular locations of two isoforms of cytochrome b5

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200210084

Signal anchor sequence insertion into the outer mitochondrial membrane. Comparison with porin and the matrix protein targeting pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200210084

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200210084

Head-head/tail-tail relative orientation of the pore-forming domains of the heterodimeric ABC transporter TAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200210084

Assembly of Bcl-2 into microsomal and outer mitochondrial membranes

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12515824

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Bcl-2 expressed using a retroviral vector is localized primarily in the nuclear membrane and the endoplasmic reticulum of chicken embryo fibroblasts

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12515824

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.200210084

1 reference

release_fx33bpfxordexoqcz4tbhwwalm

472063

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/fx33bpfxordexoqcz4tbhwwalm

mapped directly with Wikidata item

24 November 2022

based on heuristic

472063

1 reference

1 reference

1 reference