Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain (Q28581357)

31 January 2017

title

Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain (English)

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31 January 2017

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ChEBI release 2020-05-28

2

Jérôme Le Nours

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author name string

Majbritt Hansen

1

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31 January 2017

Eva Johansson

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31 January 2017

Torben Antal

4

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31 January 2017

Alexandra Ullrich

5

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31 January 2017

Monika Löffler

6

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31 January 2017

Sine Larsen

7

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31 January 2017

language of work or name

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1 April 2004

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31 January 2017

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31 January 2017

volume

13

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31 January 2017

issue

4

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31 January 2017

page(s)

1031–1042

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E. coli dihydroorotate dehydrogenase reveals structural and functional distinctions between different classes of dihydroorotate dehydrogenases

31 January 2017

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17 March 2017

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Requirements for the mitochondrial import and localization of dihydroorotate dehydrogenase

17 March 2017

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Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents

17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase

17 March 2017

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The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function

17 March 2017

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17 March 2017

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17 March 2017

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The activity of Escherichia coli dihydroorotate dehydrogenase is dependent on a conserved loop identified by sequence homology, mutagenesis, and limited proteolysis

29 September 2017

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29 September 2017

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Active site of dihydroorotate dehydrogenase A from Lactococcus lactis investigated by chemical modification and mutagenesis

29 September 2017

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Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme

29 September 2017

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Sequence analysis and identification of the pyrKDbF operon from Lactococcus lactis including a novel gene, pyrK, involved in pyrimidine biosynthesis

29 September 2017

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29 September 2017

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29 September 2017

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The B form of dihydroorotate dehydrogenase from Lactococcus lactis consists of two different subunits, encoded by the pyrDb and pyrK genes, and contains FMN, FAD, and [FeS] redox centers.

29 September 2017

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3 June 2018

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Plant dihydroorotate dehydrogenase differs significantly in substrate specificity and inhibition from the animal enzymes

3 June 2018

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Drosophila melanogaster dihydroorotate dehydrogenase: the N-terminus is important for biological function in vivo but not for catalytic properties in vitro

27 November 2018

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A new type of dihydroorotate dehydrogenase, type 1S, from the thermoacidophilic archaeon Sulfolobus solfataricus

27 November 2018

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Recombinant expression of N-terminal truncated mutants of the membrane bound mouse, rat and human flavoenzyme dihydroorotate dehydrogenase. A versatile tool to rate inhibitor effects?

27 November 2018

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Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors.

27 November 2018

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Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid

27 November 2018

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12 December 2020

Helicobacter pylori-selective antibacterials based on inhibition of pyrimidine biosynthesis

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Histidine to alanine mutants of human dihydroorotate dehydrogenase. Identification of a brequinar-resistant mutant enzyme

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12 December 2020

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12 December 2020

Identifiers

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31 January 2017

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