Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis (Q28583249)

31 January 2017

title

Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis (English)

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31 January 2017

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M. E. Tome

1

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31 January 2017

S. M. Fiser

series ordinal

2

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31 January 2017

C. M. Payne

series ordinal

3

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31 January 2017

E. W. Gerner

series ordinal

4

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31 January 2017

language of work or name

English

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publication date

15 December 1997

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31 January 2017

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31 January 2017

volume

328 ( Pt 3)

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31 January 2017

page(s)

847–854

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Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor eIF-5A

31 January 2017

cites work

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Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation

17 March 2017

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Relationship of p53 to the control of apoptotic cell death

17 March 2017

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17 March 2017

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Loss of intracellular putrescine pool-size regulation induces apoptosis

29 September 2017

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Hypusine modification in eukaryotic initiation factor 5A in rodent cells selected for resistance to growth inhibition by ornithine decarboxylase-inhibiting drugs

29 September 2017

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Effect of initiation factor eIF-5A depletion on protein synthesis and proliferation of Saccharomyces cerevisiae

29 September 2017

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Ornithine decarboxylase is a mediator of c-Myc-induced apoptosis

29 September 2017

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Rapid and regulated degradation of ornithine decarboxylase

29 September 2017

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Polyamines as targets for therapeutic intervention

29 September 2017

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Polyamine starvation prolongs the S and G2 phases of polyamine-dependent (arginase-deficient) CHO cells

29 September 2017

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29 September 2017

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Cell type-specific mechanisms of regulating expression of the ornithine decarboxylase gene after growth stimulation

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae

29 September 2017

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Pharmacological properties of the natural polyamines and their depletion by biosynthesis inhibitors as a therapeutic approach

29 September 2017

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A proposed function for spermine and spermidine: protection of replicating DNA against damage by singlet oxygen

29 September 2017

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Reversal by aminoguanidine of the inhibition of proliferation of human fibroblasts by spermidine and spermine

29 September 2017

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Mechanism of toxicity of putrescine in Anacystis nidulans

29 September 2017

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Exposure to ornithine results in excessive accumulation of putrescine and apoptotic cell death in ornithine decarboxylase overproducing mouse myeloma cells.

29 September 2017

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3 June 2018

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Effects of chronic 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxy- adenosine (AbeAdo) treatment on polyamine and eIF-5A metabolism in AbeAdo-sensitive and -resistant L1210 murine leukaemia cells

3 June 2018

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3 June 2018

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Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation

3 June 2018

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Flow cytometric analysis of the cell cycle in polyamine-depleted cells

3 June 2018

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The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine

3 June 2018

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Detection of a sub-set of polysomal mRNAs associated with modulation of hypusine formation at the G1-S boundary. Proposal of a role for eIF-5A in onset of DNA replication

3 June 2018

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Polyamine treatment in early development leads to increased numbers of rat sympathetic neurons

3 June 2018

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3 June 2018

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3 June 2018

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Polyamines can protect against ischemia-induced nerve cell death in gerbil forebrain

3 June 2018

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Stable ornithine decarboxylase in a rat hepatoma cell line selected for resistance to alpha-difluoromethylornithine

3 June 2018

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Polyamine toxicity in Neurospora crassa: Protective role of the vacuole

3 June 2018

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Mechanisms of spermine toxicity in baby-hamster kidney (BHK) cells. The role of amine oxidases and oxidative stress

3 June 2018

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Mechanism of regulation of ornithine decarboxylase gene expression by asparagine in a variant mouse neuroblastoma cell line

3 June 2018

1 reference

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Cytostasis induced in L1210 murine leukaemia cells by the S-adenosyl-L-methionine decarboxylase inhibitor 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine may be due to hypusine depletion

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218996

Unexpected cytokinetic effects induced by puromycin include a G2-arrest, a metaphase-mitotic-arrest, and apoptosis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218996

Inhibition of spermidine and spermine synthesis leads to growth arrest of rat embryo fibroblasts in G1

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218996

Features of the spermidine-binding site of deoxyhypusine synthase as derived from inhibition studies. Effective inhibition by bis- and mono-guanylated diamines and polyamines.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218996

Consequences of aberrant ornithine decarboxylase regulation in rat hepatoma cells.

27 November 2018

1 reference

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Antiproliferative effects of inhibitors of deoxyhypusine synthase. Inhibition of growth of Chinese hamster ovary cells by guanyl diamines.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218996

Protein synthesis initiation factor eIF-4D. Functional comparison of native and unhypusinated forms of the protein

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218996

IDENTIFICATION OF THE AMINOALDEHYDES PRODUCED BY THE OXIDATION OF SPERMINE AND SPERMIDINE WITH PURIFIED PLASMA AMINE OXIDASE

27 November 2018

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Preparation and stability of oxidized polyamines

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Depletion of 9L rat brain tumor cell polyamine content by treatment with D,L-alpha-difluoromethylornithine inhibits proliferation and the G1 to S transition

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High-performance liquid chromatographic procedure for the simultaneous determination of the natural polyamines and their monoacetyl derivatives

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Spermidine requirement for cell proliferation in eukaryotic cells: structural specificity and quantitation

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Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells

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Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analogue

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Diamine and Triamine Analogs and Derivatives as Inhibitors of Deoxyhypusine Synthase: Synthesis and Biological Activity

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Involvement of ornithine decarboxylase and polyamines in glucocorticoid-induced apoptosis of rat thymocytes

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Effects of inhibitors of deoxyhypusine synthase on the differentiation of mouse neuroblastoma and erythroleukemia cells

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Inhibition of translation of mRNAs for ornithine decarboxylase and S-adenosylmethionine decarboxylase by polyamines

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Hypusine formation in protein by a two-step process in cell lysates

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The essential role of hypusine in eukaryotic translation initiation factor 4D (eIF-4D). Purification of eIF-4D and its precursors and comparison of their activities

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Abnormal accumulation and toxicity of polyamines in a difluoromethylornithine-resistant HTC cell variant

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Identifiers

PMC publication ID

1218996

0 references

1 reference