Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury (Q28584092)

31 January 2017

title

Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury (English)

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31 January 2017

Xiaodong Li

1

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31 January 2017

Mario Grisanti

2

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Wei Fan

3

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31 January 2017

Frank J. Asuncion

4

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Hong-Lin Tan

5

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Denise Dwyer

6

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Chun-Ya Han

7

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Longchuan Yu

8

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Jae Lee

9

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Edward Lee

10

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Mauricio Barrero

11

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Pam Kurimoto

12

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Qing-Tian Niu

13

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Zhaopo Geng

14

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Aaron Winters

15

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Tom Horan

16

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Shirley Steavenson

17

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Frederick Jacobsen

18

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Qing Chen

19

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Raj Haldankar

20

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Jennifer Lavallee

21

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Barbara Tipton

22

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Mark Daris

23

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Jackie Sheng

24

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Hsieng S. Lu

25

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Kristi Daris

26

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Rohini Deshpande

27

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Eliane G. Valente

28

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Hossein Salimi-Moosavi

29

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Paul J. Kostenuik

30

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Ji Li

31

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Min Liu

32

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Chaoyang Li

33

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David L. Lacey

34

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W. Scott Simonet

35

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Hua Zhu Ke

36

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Philip Babij

37

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Marina Stolina

38

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Michael S. Ominsky

39

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William G. Richards

40

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31 January 2017

publication date

1 November 2011

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Journal of Bone and Mineral Research

31 January 2017

published in

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31 January 2017

volume

26

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31 January 2017

issue

11

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31 January 2017

page(s)

2610–2621

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Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone

31 January 2017

cites work

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LRP5 and Wnt signaling: a union made for bone

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Wnt signaling: a win for bone

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High bone density due to a mutation in LDL-receptor-related protein 5

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A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

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The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations

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A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V).

21 January 2018

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Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

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Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

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Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

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Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

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The role of Dickkopf-1 in bone development, homeostasis, and disease

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The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma

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Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma.

21 January 2018

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Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma

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Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo

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Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints.

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Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

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Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.

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Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6.

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Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse

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Gene therapy with human recombinant osteoprotegerin reverses established osteopenia in ovariectomized mice

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Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee

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Differential effects of androgens on cortical bone histomorphometry in gonadectomized male and female rats

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Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements.

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Fundamental principles of in situ hybridization

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Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo

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Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma

21 January 2018

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Apc tumor suppressor gene is the "zonation-keeper" of mouse liver

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Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1.

21 January 2018

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Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis

21 January 2018

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Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

21 January 2018

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Essential role of beta-catenin in postnatal bone acquisition

21 January 2018

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WNT/beta-catenin signaling is involved in regulation of osteoclast differentiation by human immunodeficiency virus protease inhibitor ritonavir: relationship to human immunodeficiency virus-linked bone mineral loss

21 January 2018

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Characterization of Wnt/beta-catenin signalling in osteoclasts in multiple myeloma

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Wnt pathway, an essential role in bone regeneration

21 January 2018

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Beta-catenin in the race to fracture repair: in it to Wnt.

21 January 2018

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Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing

21 January 2018

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Is Wnt signalling the final common pathway leading to bone formation?

21 January 2018

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Wnt signaling in bone metabolism

21 January 2018

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