Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1 (Q28585290)

Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation

GOA release 2020-03-11

author name string

Arthur Liberzon

series ordinal

1

1 reference

31 January 2017

Gabriela Ridner

series ordinal

2

1 reference

31 January 2017

Michael D. Walker

series ordinal

3

1 reference

31 January 2017

language of work or name

English

0 references

publication date

1 January 2004

1 reference

31 January 2017

Nucleic Acids Research

1 reference

31 January 2017

32

1 reference

31 January 2017

1

1 reference

31 January 2017

54–64

1 reference

31 January 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

PDX:PBX complexes are required for normal proliferation of pancreatic cells during development

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

Hox proteins have different affinities for a consensus DNA site that correlate with the positions of their genes on the hox cluster

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

17 March 2017

1 reference

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Sequence logos: a new way to display consensus sequences

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1 reference

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Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A resolution: a framework for understanding homeodomain-DNA interactions

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1 reference

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Homeobox genes and axial patterning

17 March 2017

1 reference

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Insulin-promoter-factor 1 is required for pancreas development in mice

17 March 2017

1 reference

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Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection

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1 reference

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Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells

7 April 2017

1 reference

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Experimental conversion of liver to pancreas

29 September 2017

1 reference

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Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3beta transcription factors mediate beta-cell-specific expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

Regulation of insulin gene transcription

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2).

29 September 2017

1 reference

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beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

29 September 2017

1 reference

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Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

A structural model for a homeotic protein-extradenticle-DNA complex accounts for the choice of HOX protein in the heterodimer

29 September 2017

1 reference

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Selection of protein binding sites from random nucleic acid sequences

29 September 2017

1 reference

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Nucleotides flanking a conserved TAAT core dictate the DNA binding specificity of three murine homeodomain proteins

29 September 2017

1 reference

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Differential DNA-binding specificity of the engrailed homeodomain: the role of residue 50.

29 September 2017

1 reference

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29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain.

29 September 2017

1 reference

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Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells

29 September 2017

1 reference

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The specificity of homeotic gene function

29 September 2017

1 reference

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Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins

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1 reference

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A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans.

29 September 2017

1 reference

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Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells

29 September 2017

1 reference

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A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer

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1 reference

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DNA binding specificity of homeodomains

29 September 2017

1 reference

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DNA-binding specificity of the fushi tarazu homeodomain

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1 reference

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Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila

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Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells

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1 reference

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Regulation of segmentation and segmental identity by Drosophila homeoproteins: the role of DNA binding in functional activity and specificity.

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1 reference

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