Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes (Q28586442)

GOA release 2020-03-11

author name string

H. Kawate

1

1 reference

31 January 2017

K. Sakumi

2

1 reference

31 January 2017

T. Tsuzuki

3

1 reference

31 January 2017

Y. Nakatsuru

4

1 reference

31 January 2017

T. Ishikawa

5

1 reference

31 January 2017

S. Takahashi

6

1 reference

31 January 2017

H. Takano

7

1 reference

31 January 2017

T. Noda

8

1 reference

31 January 2017

M. Sekiguchi

Proceedings of the National Academy of Sciences of the United States of America

9

1 reference

31 January 2017

language of work or name

English

0 references

publication date

28 April 1998

1 reference

31 January 2017

1 reference

31 January 2017

95

1 reference

31 January 2017

9

1 reference

31 January 2017

5116–5120

1 reference

31 January 2017

Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

Mismatch repair: mechanisms and relationship to cancer susceptibility

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

Mutation of a mutL homolog in hereditary colon cancer

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

Regulation and expression of the adaptive response to alkylating agents

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

Mismatch repair in replication fidelity, genetic recombination, and cancer biology

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

A mutation in the MSH5 gene results in alkylation tolerance

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

DNA-repair methyltransferase as a molecular device for preventing mutation and cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

DNA damage tolerance, mismatch repair and genome instability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

DNA mismatch repair mutants do not increase N-methyl-N'-nitro-N-nitrosoguanidine tolerance in O6-methylguanine DNA methyltransferase-deficient yeast cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

Genetic studies of the lac repressor. IV. Mutagenic specificity in the lacI gene of Escherichia coli

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

Human tumor cell strains defective in the repair of alkylation damage.

3 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.9.5116

Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.9.5116

Mouse methyltransferase for repair of O6-methylguanine and O4-methylthymine in DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.9.5116

Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.9.5116

Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

Purification and structure of the intact Ada regulatory protein of Escherichia coli K12, O6-methylguanine-DNA methyltransferase.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20223

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

27 November 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.9.5116

Mismatch correction at O 6 -methylguanine residues in E. coli DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.9.5116

N-Methyl-N'-nitro-N-nitrosoguanidine sensitivity of E. coli mutants deficient in DNA methylation and mismatch repair

21 January 2018

1 reference

12 December 2020

Repair of O6-methylguanine in DNA by demethylation is lacking in Mer- human tumor cell strains

1 reference

12 December 2020

Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent

1 reference

12 December 2020

Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene

1 reference

12 December 2020

Organization and expression of the human gene for O6-methylguanine-DNA methyltransferase

1 reference

12 December 2020

The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase

1 reference

12 December 2020