M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere (Q28588265)

GOA release 2020-03-11

Michael Gotthardt

5

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author name string

Stefanie Weinert

1

1 reference

31 January 2017

Nora Bergmann

2

1 reference

31 January 2017

Xiuju Luo

3

1 reference

31 January 2017

Bettina Erdmann

The M-band: an elastic web that crosslinks thick filaments in the center of the sarcomere

4

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31 January 2017

language of work or name

English

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publication date

22 May 2006

1 reference

31 January 2017

Journal of Cell Biology

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31 January 2017

173

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31 January 2017

4

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31 January 2017

559–570

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31 January 2017

1 reference

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Dimerisation of myomesin: implications for the structure of the sarcomeric M-band

17 March 2017

1 reference

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A Titin mutation defines roles for circulation in endothelial morphogenesis

17 March 2017

1 reference

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Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles

17 March 2017

1 reference

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Telethonin protein expression in neuromuscular disorders

17 March 2017

1 reference

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The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system

17 March 2017

1 reference

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Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy.

17 March 2017

1 reference

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Antisense oligonucleotide experiments elucidate the essential role of titin in sarcomerogenesis in adult rat cardiomyocytes in long-term culture

17 March 2017

1 reference

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The muscle regulatory and structural protein MLP is a cytoskeletal binding partner of betaI-spectrin

17 March 2017

1 reference

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Limb-girdle muscular dystrophy type 2G is caused by mutations in the gene encoding the sarcomeric protein telethonin

17 March 2017

1 reference

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Different domains of the M-band protein myomesin are involved in myosin binding and M-band targeting

17 March 2017

1 reference

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The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity

17 March 2017

1 reference

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Structural basis for activation of the titin kinase domain during myofibrillogenesis

17 March 2017

1 reference

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Human autoantibodies reveal titin as a chromosomal protein

17 March 2017

1 reference

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Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin.

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063865

Molecular structure of the sarcomeric M band: mapping of titin and myosin binding domains in myomesin and the identification of a potential regulatory phosphorylation site in myomesin.

17 March 2017

1 reference

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Cellular titin localization in stress fibers and interaction with myosin II filaments in vitro

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063865

Titins: giant proteins in charge of muscle ultrastructure and elasticity

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063865

The positional stability of thick filaments in activated skeletal muscle depends on sarcomere length: evidence for the role of titin filaments

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063865

Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells

17 March 2017

1 reference

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De novo myofibrillogenesis in C2C12 cells: evidence for the independent assembly of M bands and Z disks

7 April 2017

1 reference

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The kinase domain of titin controls muscle gene expression and protein turnover

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063865

Mechanically induced titin kinase activation studied by force-probe molecular dynamics simulations

29 September 2017

1 reference

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Obscurin regulates the organization of myosin into A bands

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063865

M-band: a safeguard for sarcomere stability?

29 September 2017

1 reference

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FILAMENT LENGTHS IN STRIATED MUSCLE

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063865

Multiple antibodies to titin immunoreact with AHNAK and localize to the mitotic spindle machinery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063865

D-Titin: a giant protein with dual roles in chromosomes and muscles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063865

From connecting filaments to co-expression of titin isoforms

29 September 2017

1 reference

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Role of titin in nonmuscle and smooth muscle cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063865

Assembly of myofibrils in cardiac muscle cells.

29 September 2017

1 reference

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Myofibrillogenesis visualized in living embryonic cardiomyocytes

29 September 2017

1 reference

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The structure of the sarcomeric M band: localization of defined domains of myomesin, M-protein, and the 250-kD carboxy-terminal region of titin by immunoelectron microscopy.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063865

Titin as a scaffold and spring. Cytoskeleton

29 September 2017

1 reference

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Ultrastructural and functional features of the developing mammalian heart: a brief overview

29 September 2017

1 reference

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Immunocytochemical studies of cardiac myofibrillogenesis in early chick embryos. II. Generation of alpha-actinin dots within titin spots at the time of the first myofibril formation

29 September 2017

1 reference

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Elastic behavior of connectin filaments during thick filament movement in activated skeletal muscle

29 September 2017

1 reference

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Myogenesis in the mouse embryo: differential onset of expression of myogenic proteins and the involvement of titin in myofibril assembly

29 September 2017

1 reference

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The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at the Z line extends close to the M line

29 September 2017

1 reference

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Differential distribution of subsets of myofibrillar proteins in cardiac nonstriated and striated myofibrils

29 September 2017

1 reference

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Identification and characterization of two huge protein components of the brush border cytoskeleton: evidence for a cellular isoform of titin

29 September 2017

1 reference

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Muscle atrophy in Titin M-line deficient mice

29 September 2017

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Sequential myofibrillar breakdown accompanies mitotic division of mammalian cardiomyocytes

27 November 2018

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Developmentally regulated switching of titin size alters myofibrillar stiffness in the perinatal heart

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063865

Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063865

A targeted deletion of the C-terminal end of titin, including the titin kinase domain, impairs myofibrillogenesis.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063865

Vertical agarose gel electrophoresis and electroblotting of high-molecular-weight proteins

27 November 2018

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Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure

27 November 2018

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Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin

27 November 2018

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Assembly of thick, thin, and titin filaments in chick precardiac explants

27 November 2018

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Thick filament assembly occurs after the formation of a cytoskeletal scaffold.

27 November 2018

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Integration of titin into the sarcomeres of cultured differentiating human skeletal muscle cells.

27 November 2018

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27 November 2018

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The muscular dystrophy with myositis (mdm) mouse mutation disrupts a skeletal muscle-specific domain of titin

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16702235

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Molecular mechanisms of myofibril assembly in heart

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16702235

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Myofibrillogenesis in the developing chicken heart: assembly of Z-disk, M-line and the thick filaments

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16702235

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.200601014

1 reference

3564955

3564955

1 reference

1 reference

1 reference