Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system (Q28589282)

31 January 2017

title

Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system (English)

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31 January 2017

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GOA release 2020-03-11

8

Dan M. Roden

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31 January 2017

Patrick Y. Jay

1

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31 January 2017

Brett S. Harris

2

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31 January 2017

Colin T. Maguire

3

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31 January 2017

Antje Buerger

4

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31 January 2017

Hiroko Wakimoto

5

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31 January 2017

Makoto Tanaka

6

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31 January 2017

Sabina Kupershmidt

7

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31 January 2017

Thomas M. Schultheiss

9

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31 January 2017

Terrence X. O'Brien

10

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31 January 2017

Robert G. Gourdie

11

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31 January 2017

Charles I. Berul

12

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31 January 2017

Seigo Izumo

13

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31 January 2017

language of work or name

English

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publication date

1 April 2004

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Journal of Clinical Investigation

31 January 2017

published in

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31 January 2017

volume

113

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31 January 2017

issue

8

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31 January 2017

page(s)

1130–1137

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Neuregulin-1 promotes formation of the murine cardiac conduction system

31 January 2017

cites work

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A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

17 March 2017

1 reference

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Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=385399

Dosage requirement of Pitx2 for development of multiple organs

17 March 2017

1 reference

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The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=385399

Congenital heart disease caused by mutations in the transcription factor NKX2-5

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=385399

Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=385399

Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5

17 March 2017

1 reference

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An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

17 March 2017

1 reference

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Development of the cardiac conduction system involves recruitment within a multipotent cardiomyogenic lineage.

7 April 2017

1 reference

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Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers

29 September 2017

1 reference

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Validation of immunohistochemical quantification in confocal scanning laser microscopy: a comparative assessment of gap junction size with confocal and ultrastructural techniques.

29 September 2017

1 reference

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The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=385399

The development of the conduction system in the mouse embryo heart. II. Histogenesis of the atrioventricular node and bundle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=385399

The development of the conduction system in the mouse embryo heart. I. The first embryonic A-V conduction pathway

3 June 2018

1 reference

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Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction system.

3 June 2018

1 reference

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Development of the Cardiac Conduction System as Delineated by minK‐lacZ

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=385399

Ventricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=385399

Elevated expression of Nkx-2.5 in developing myocardial conduction cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=385399

Connexin40-deficient mice exhibit atrioventricular nodal and infra-Hisian conduction abnormalities.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=385399

The rate and anisotropy of impulse propagation in the postnatal terminal crest are correlated with remodeling of Cx43 gap junction pattern.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=385399

Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=385399

Measurement of heart rate and Q-T interval in the conscious mouse.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=385399

Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=385399

Evidence for a distinct gap-junctional phenotype in ventricular conduction tissues of the developing and mature avian heart.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=385399

Maturational atrioventricular nodal physiology in the mouse

27 November 2018

1 reference

12 December 2020

Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5

1 reference

12 December 2020

High-resolution optical mapping of the right bundle branch in connexin40 knockout mice reveals slow conduction in the specialized conduction system

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12 December 2020

Divergent expression of delayed rectifier K+ channel subunits during mouse heart development

1 reference

12 December 2020

Increased association of ZO-1 with connexin43 during remodeling of cardiac gap junctions

1 reference

12 December 2020

Spectrum and progression of conduction abnormalities in infants born to mothers with anti-SSA/Ro-SSB/La antibodies

1 reference

12 December 2020

A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5.

1 reference

12 December 2020

The development of the conduction system in the mouse embryo heart

1 reference

12 December 2020

Immunohistochemical delineation of the conduction system. II: The atrioventricular node and Purkinje fibers

1 reference

12 December 2020

Terminal diversification of the myocyte lineage generates Purkinje fibers of the cardiac conduction system

1 reference

12 December 2020

In vivo cardiac electrophysiology studies in the mouse

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12 December 2020

Connexin45 (alpha 6) expression delineates an extended conduction system in the embryonic and mature rodent heart

1 reference

12 December 2020

Identifiers

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31 January 2017

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