Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice (Q28590225)

31 January 2017

title

Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice (English)

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Purine-nucleoside phosphorylase

31 January 2017

main subject

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GOA release 2020-03-11

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E. Arpaia

1

1 reference

31 January 2017

P. Benveniste

2

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31 January 2017

A. Di Cristofano

3

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31 January 2017

Y. Gu

4

1 reference

31 January 2017

I. Dalal

5

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31 January 2017

S. Kelly

6

1 reference

31 January 2017

M. Hershfield

7

1 reference

31 January 2017

P. P. Pandolfi

8

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31 January 2017

C. M. Roifman

9

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31 January 2017

A. Cohen

10

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31 January 2017

language of work or name

English

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publication date

19 June 2000

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Journal of Experimental Medicine

31 January 2017

published in

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31 January 2017

volume

191

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31 January 2017

issue

12

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31 January 2017

page(s)

2197–2208

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p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

31 January 2017

cites work

1 reference

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17 March 2017

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17 March 2017

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Point mutations at the purine nucleoside phosphorylase locus impair thymocyte differentiation in the mouse

17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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Purine nucleoside phosphorylase deficiency

17 March 2017

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Absence of dGTP accumulation and compensatory loss of deoxyguanosine kinase in purine nucleoside phosphorylase deficient mice

17 March 2017

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Abnormal purine metabolism and purine overproduction in a patient deficient in purine nucleoside phosphorylase

17 March 2017

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7 April 2017

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A purine nucleoside phosphorylase (PNP) inhibitor induces apoptosis via caspase-3-like protease activity in MOLT-4 T cells

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Possible metabolic basis for the different immunodeficient states associated with genetic deficiencies of adenosine deaminase and purine nucleoside phosphorylase

29 September 2017

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29 September 2017

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Control of Nucleotide Pools in Mammalian Cells

29 September 2017

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29 September 2017

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Central nervous system dysfunction and erythrocyte guanosine triphosphate depletion in purine nucleoside phosphorylase deficiency

29 September 2017

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29 September 2017

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Purine Nucleoside Phosphorylase Deficiency Associated with Selective Cellular Immunodeficiency

29 September 2017

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29 September 2017

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Deoxyadenosine metabolism and cytotoxicity in cultured mouse T lymphoma cells: a model for immunodeficiency disease

29 September 2017

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Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Possible role of nucleoside kinase(s)

29 September 2017

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Cellular immunodeficiency associated with nucleoside phosphorylase deficiency. Immunologic and biochemical studies

29 September 2017

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Isolation and characterization of purine-nucleoside phosphorylase-deficient T-lymphoma cells and secondary mutants with altered ribonucleotide reductase: Genetic model for immunodeficiency disease

29 September 2017

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Deoxyguanosine toxicity in a mouse T lymphoma: Relationship to purine nucleoside phosphorylase-associated immune dysfunction

29 September 2017

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Deoxyguanosine Triphosphate as a Possible Toxic Metabolite in the Immunodeficiency Associated with Purine Nucleoside Phosphorylase Deficiency

29 September 2017

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Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity

29 September 2017

1 reference

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Preparation and characterization of an endogenously fluorescent annexin for detection of apoptotic cells.

29 September 2017

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Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells

3 June 2018

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Purine nucleoside phosphorylase (PNP) deficiency

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193200

Mitochondrial permeability transition triggers lymphocyte apoptosis.

3 June 2018

1 reference

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Stroke in purine nucleoside phosphorylase deficiency

3 June 2018

1 reference

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bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

3 June 2018

1 reference

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Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore

3 June 2018

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Enhanced cytotoxicity of nucleoside analogs by overexpression of mitochondrial deoxyguanosine kinase in cancer cell lines

27 November 2018

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Ribonucleotide reductase: evidence for specific association with HeLa cell mitochondria.

27 November 2018

1 reference

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Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity

27 November 2018

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12 December 2020

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

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12 December 2020

The expression of deoxyguanosine toxicity in T lymphocytes at different stages of maturation

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12 December 2020

GTP depletion and other erythrocyte abnormalities in inherited PNP deficiency

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12 December 2020

Regulation of human placental deoxyguanosine kinase by nucleotides

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12 December 2020

Purine and pyrimidine metabolism in human T lymphocytes. Regulation of deoxyribonucleotide metabolism

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12 December 2020

Purine metabolism in human T lymphocytes: role of the purine nucleoside cycle

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12 December 2020

DNA repair in nondividing human lymphocytes: inhibition by deoxyadenosine

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12 December 2020

Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers

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12 December 2020

Guanine nucleotide metabolism in red blood cells: the metabolic basis for GTP depletion in HGPRT and PNP deficiency

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12 December 2020

Properties and levels of deoxynucleoside kinases in normal and tumor cells; implications for chemotherapy

1 reference

12 December 2020

Kinetic mechanism and end-product regulation of deoxyguanosine kinase from beef liver mitochondria

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12 December 2020

Purine nucleoside phosphorylase deficient mice exhibit both an age dependent attrition of thymocytes and impaired thymocyte differentiation

1 reference

12 December 2020

Phosphorylation of anticancer nucleoside analogs by human mitochondrial deoxyguanosine kinase

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12 December 2020

Identifiers

DOI

10.1084/JEM.191.12.2197

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PMC publication ID

2193200

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1 reference