Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic mice (Q28590402)

GOA release 2020-03-11

1 reference

Jeremy W. Rupon

1

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31 January 2017

Shou Zhen Wang

2

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31 January 2017

Karin Gaensler

3

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31 January 2017

Joyce Lloyd

4

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31 January 2017

Gordon D. Ginder

Proceedings of the National Academy of Sciences of the United States of America

5

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31 January 2017

language of work or name

English

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publication date

25 April 2006

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31 January 2017

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31 January 2017

103

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31 January 2017

17

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31 January 2017

6617–6622

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31 January 2017

Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing

1 reference

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Kaiso is a genome-wide repressor of transcription that is essential for amphibian development

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1 reference

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Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly

17 March 2017

1 reference

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The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

17 March 2017

1 reference

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A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

17 March 2017

1 reference

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The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

17 March 2017

1 reference

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Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2

17 March 2017

1 reference

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Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

7 April 2017

1 reference

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Kaiso-deficient mice show resistance to intestinal cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

A GATA factor mediates cell type-restricted induction of HLA-E gene transcription by gamma interferon

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Gene silencing quantitatively controls the function of a developmental trans-activator

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Methylation of the minimal promoter of an embryonic globin gene silences transcription in primary erythroid cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

29 September 2017

CpG islands and genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Number of CpG islands and genes in human and mouse

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Tissue-specific DNA methylation in a cluster of rabbit beta-like globin genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

DNA methylation in the human γδβ-globin locus in erythroid and nonerythroid tissues

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

DNA methylation and regulation of the human beta-globin-like genes in mouse erythroleukemia cells containing human chromosome 11

29 September 2017

1 reference

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Activation of a chicken embryonic globin gene in adult erythroid cells by 5-azacytidine and sodium butyrate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

5-Azacytidine acts directly on both erythroid precursors and progenitors to increase production of fetal hemoglobin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Methylation of promoter proximal-transcribed sequences of an embryonic globin gene inhibits transcription in primary erythroid cells and promotes formation of a cell type-specific methyl cytosine binding complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

The human beta globin locus introduced by YAC transfer exhibits a specific and reproducible pattern of developmental regulation in transgenic mice.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

alpha-Amino butyric acid cannot reactivate the silenced gamma gene of the beta locus YAC transgenic mouse.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Arabinosylcytosine Induces Fetal Hemoglobin in Baboons by Perturbing Erythroid Cell Differentiation Kinetics

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Stimulation of F-cell production in patients with sickle-cell anemia treated with cytarabine or hydroxyurea

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Regulation of human fetal and adult globin genes in mouse erythroleukemia cells.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Specific DNA methylation sites in the vicinity of the chicken beta-globin genes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1458932

Effect of phenylhydrazine-induced hemolytic anemia on nuclear RNA polymerase activity of the mouse spleen

27 November 2018

1 reference

12 December 2020

5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β+Thalassemia

1 reference

12 December 2020

5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia

1 reference

12 December 2020

Augmentation of Fetal-Hemoglobin Production in Anemic Monkeys by Hydroxyurea

1 reference

12 December 2020

DNA methylation: a secondary event in globin gene switching?

1 reference

12 December 2020

Butyrate induces selective transcriptional activation of a hypomethylated embryonic globin gene in adult erythroid cells

1 reference

12 December 2020

Metabolic persistence of fetal hemoglobin

1 reference

12 December 2020

2-deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0509322103

1 reference

2340344

ADS bibcode

2006PNAS..103.6617R

0 references

2340344

1 reference

1 reference

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