The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity (Q28591617)

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author name string

R. Scott Heller

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31 January 2017

Doris A. Stoffers

2

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31 January 2017

Aihua Liu

3

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31 January 2017

E. Bryan Crenshaw

5

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31 January 2017

Ole D. Madsen

Pax6 and Cdx2/3 form a functional complex on the rat glucagon gene promoter G1-element

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31 January 2017

language of work or name

English

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publication date

1 April 2004

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31 January 2017

Developmental Biology

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31 January 2017

268

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31 January 2017

1

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31 January 2017

123–134

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31 January 2017

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

Pax6 and Pdx1 form a functional complex on the rat somatostatin gene upstream enhancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

Association between X-linked mixed deafness and mutations in the POU domain gene POU3F4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

Molecular genetics of the Pax gene family.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

Mouse mutations and human disorders are paired

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

Mouse small eye results from mutations in a paired-like homeobox-containing gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

POU domain transcription factor brain 4 confers pancreatic alpha-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

The caudal homeobox protein cdx-2/3 activates endogenous proglucagon gene expression in InR1-G9 islet cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

Interaction of Maf transcription factors with Pax-6 results in synergistic activation of the glucagon promoter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008

Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2003.12.008