Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation (Q28592987)

GOA release 2020-03-11

Cell division cycle 42

1 reference

GOA release 2020-03-11

John Sondek

7

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author name string

Kent L. Rossman

1

1 reference

31 January 2017

Li Cheng

2

1 reference

31 January 2017

Gwendolyn M. Mahon

3

1 reference

31 January 2017

Rafael J. Rojas

4

1 reference

31 January 2017

Jason T. Snyder

5

1 reference

31 January 2017

Ian P. Whitehead

Journal of Biological Chemistry

6

1 reference

31 January 2017

language of work or name

English

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publication date

16 May 2003

1 reference

31 January 2017

1 reference

31 January 2017

278

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31 January 2017

20

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31 January 2017

18393–18400

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31 January 2017

Rho GTPases and signaling networks

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Rho GTPases and the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Rho GTPases and their effector proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Signaling to the Rho GTPases: networking with the DH domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

The pleckstrin homology domain mediates transformation by oncogenic dbl through specific intracellular targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Expression cloning of lfc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Expression cloning of lsc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Modulation of oncogenic DBL activity by phosphoinositol phosphate binding to pleckstrin homology domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Biological assays for Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

DOCK 4.0: Search strategies for automated molecular docking of flexible molecule databases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

The molecular surface package

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

The role of the PH domain in the signal-dependent membrane targeting of Sos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Structure and mutagenesis of the Dbl homology domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Regulation of proto-Dbl by intracellular membrane targeting and protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Dissociation of GDP dissociation inhibitor and membrane translocation are required for efficient activation of Rac by the Dbl homology-pleckstrin homology region of Tiam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300127200