Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development (Q28593581)

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

GOA release 2020-03-11

author name string

K. R. Thomas

series ordinal

1

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31 January 2017

M. R. Capecchi

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2

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31 January 2017

language of work or name

English

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publication date

30 August 1990

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31 January 2017

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31 January 2017

346

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31 January 2017

847–850

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31 January 2017

6287

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31 January 2017

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7 January 2021

Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact.

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7 January 2021

Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development

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7 January 2021

Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos.

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7 January 2021

Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo

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7 January 2021

The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

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7 January 2021

The development of wingless, a homeotic mutation of Drosophila

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7 January 2021

Molecular cloning of sequences from wingless, a segment polarity gene in Drosophila: the spatial distribution of a transcript in embryos.

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7 January 2021

The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway

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7 January 2021

Secreted int-1 protein is associated with the cell surface

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7 January 2021

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

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7 January 2021

Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines

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7 January 2021

The new mouse genetics: altering the genome by gene targeting

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7 January 2021

Altering the genome by homologous recombination

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7 January 2021

Towards a molecular-genetic analysis of mammalian development

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7 January 2021

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

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7 January 2021

Targeted mutation of the Hprt gene in mouse embryonic stem cells

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7 January 2021

Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination.

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7 January 2021

Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells.

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7 January 2021

Targeting of nonexpressed genes in embryonic stem cells via homologous recombination

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7 January 2021

Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination

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7 January 2021

Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells

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7 January 2021

Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells.

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7 January 2021

Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.

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7 January 2021

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.

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7 January 2021

Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.

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7 January 2021

Homologous recombination in hybridoma cells: heavy chain chimeric antibody produced by gene targeting

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7 January 2021

Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein

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7 January 2021

Identifiers

DOI

10.1038/346847A0

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

3092075

1027532470

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3092075

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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