Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions (Q28609925)

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Radical cation intermediates in N-dealkylation reactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

On the oncogenic activity of ethylene oxide and propylene oxide in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Pharmacokinetics of ethylene in man; body burden with ethylene oxide and hydroxyethylation of hemoglobin due to endogenous and environmental ethylene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Metabolism of [14C]- and [36Cl]-labeled vinyl chloride in vivo and in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Activation of vinyl chloride to covalently bound metabolites: roles of 2-chloroethylene oxide and 2-chloroacetaldehyde

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Olefin oxidation by cytochrome P-450: evidence for group migration in catalytic intermediates formed with vinylidene chloride and trans-1-phenyl-1-butene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Oxidation of trichloroethylene by liver microsomal cytochrome P-450: evidence for chlorine migration in a transition state not involving trichloroethylene oxide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Tetrachloroethylene oxide: hydrolytic products and reactions with phosphate and lysine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Vinyl carbamate epoxide, a major strong electrophilic, mutagenic and carcinogenic metabolite of vinyl carbamate and ethyl carbamate (urethane).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Vinyl chloride and vinyl benzene (styrene) — Metabolism, mutagenicity and carcinogenicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Mutagenicity of acrylonitrile and its metabolite 2-cyanoethylene oxide in human lymphoblasts in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Mutational spectrum of 1,3-butadiene and metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane to assess mutagenic mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Mutagenicity of butadiene and its epoxide metabolites: I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Epoxidation of olefins by cytochrome P-450 model compounds: kinetics and stereochemistry of oxygen atom transfer and origin of shape selectivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Oxidation of monosubstituted olefins by cytochromes P-450 and heme models: evidence for the formation of aldehydes in addition to epoxides and allylic alcohols

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Multi-state epoxidation of ethene by cytochrome P450: a quantum chemical study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

An epoxide is an intermediate in the microsomal metabolism of the chemical carcinogen, dibenz(a,h)anthracene.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

1,2-Naphthalene oxide as an intermediate in the microsomal hydroxylation of naphthalene. V

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Hydroxylation-induced migration: the NIH shift. Recent experiments reveal an unexpected and general result of enzymatic hydroxylation of aromatic compounds

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Migration of deuterium during hydroxylation of aromatic substrates by liver microsomes: I. Influence of ring substituents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Microsomal hydroxylation of specifically deuterated monosubstituted benzenes. Evidence for direct aromatic hydroxylation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Isotopically labeled chlorobenzenes as probes for the mechanism of cytochrome P-450 catalyzed aromatic hydroxylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

A new hypothesis for the mechanism for cytochrome P-450 dependent aerobic conversion of hexahalogenated benzenes to pentahalogenated phenols

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Cytochrome P450-catalyzed oxidation of halobenzene derivatives

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

The role of 4-bromophenol and 4-bromocatechol in bromobenzene covalent binding and toxicity in isolated rat hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Identification of epoxide- and quinone-derived bromobenzene adducts to protein sulfur nucleophiles

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

The pharmacology and toxicology of polyphenolic-glutathione conjugates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Oxidation of 9-alkylanthracenes by cytochrome P450 2B1, horseradish peroxidase, and iron tetraphenylporphine/iodosylbenzene systems: anaerobic and aerobic mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Hepatic necrosis caused by furosemide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Reactive metabolites from the bioactivation of toxic methylfurans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Studies on the activation of a model furan compound--toxicity and covalent binding of 2-(N-ethylcarbamoylhydroxymethyl)furan

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Studies on the interaction of furan with hepatic cytochrome P-450

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Pyrrolic metabolites from non-toxic pyrrolizidine alkaloids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Recovery of the pyrrolic nucleus of pyrrolizidine alkaloid metabolites from sulphur conjugates in tissues and body fluids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Structure of the aflatoxin B(1) dialdehyde adduct formed from reaction with methylamine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furosemide and cephaloridine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Evidence for thiophene-S-oxide as a primary reactive metabolite of thiophene in vivo: formation of a dihydrothiophene sulfoxide mercapturic acid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Thiophene sulfoxides as reactive metabolites: formation upon microsomal oxidation of a 3-aroylthiophene and fate in the presence of nucleophiles in vitro and in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Chemical and Biological Oxidation of Thiophene: Preparation and Complete Characterization of ThiopheneS-Oxide Dimers and Evidence for ThiopheneS-Oxide as an Intermediate in Thiophene Metabolismin Vivoandin Vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Review of epidemiologic study results of vinyl chloride-related compounds

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Roles of the vinyl chloride oxidation products 1-chlorooxirane and 2-chloroacetaldehyde in the in vitro formation of etheno adducts of nucleic acid bases [corrected]

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Formation of 1,N2- and N2,3-ethenoguanine from 2-halooxiranes: isotopic labeling studies and isolation of a hemiaminal derivative of N2-(2-oxoethyl)guanine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Mechanism of formation of ethenoguanine adducts from 2-haloacetaldehydes: 13C-labeling patterns with 2-bromoacetaldehyde

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Reaction of trichloroethylene and trichloroethylene oxide with cytochrome P450 enzymes: inactivation and sites of modification

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Metabolism of tetrachloroethene in rats: identification of N epsilon-(dichloroacetyl)-L-lysine and N epsilon-(trichloroacetyl)-L-lysine as protein adducts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Acylation of protein lysines by trichloroethylene oxide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Reaction of trichloroethylene oxide with proteins and dna: instability of adducts and modulation of functions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

S-(2-chloroacetyl)glutathione, a reactive glutathione thiol ester and a putative metabolite of 1,1-dichloroethylene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

1,N6 formation, mutagenicity and murine tumor induction as indicators of the generation of an electrophilic epoxide metabolite of the closely related carcinogens ethyl carbamate (urethane) and vinyl carbamate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Enzymatic oxidation of ethyl carbamate to vinyl carbamate and its role as an intermediate in the formation of 1,N6-ethenoadenosine.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Cytochrome P-450--catalyzed formation of delta 4-VPA, a toxic metabolite of valproic acid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Synthesis and properties of vinyl carbamate epoxide, a possible ultimate electrophilic and carcinogenic metabolite of vinyl carbamate and ethyl carbamate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Inhibition of vinyl carbamate-induced hepatotoxicity, mutagenicity, and tumorigenicity by isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2- yl)carbamoyl]acetate (YH439).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

N-nitroso-N-methylvinylamine: reaction of the epoxide with guanyl and adenyl moieties to yield adducts derived from both parts of the molecule

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Kinetics of hydrolysis and reaction of aflatoxin B1 exo-8,9-epoxide and relevance to toxicity and detoxication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Reaction of aflatoxin B(1) oxidation products with lysine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Conjugation of Highly Reactive Aflatoxin B1exo-8,9-Epoxide Catalyzed by Rat and Human Glutathione Transferases: Estimation of Kinetic Parameters†

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Reaction of aflatoxin B1 exo-8,9-epoxide with DNA: kinetic analysis of covalent binding and DNA-induced hydrolysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Preparation of aflatoxin B1 8,9-epoxide using m-chloroperbenzoic acid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

The endo-8,9-epoxide of aflatoxin B1: a new metabolite

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Glutathione conjugation of aflatoxin B1 exo- and endo-epoxides by rat and human glutathione S-transferases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Acidic domains around nucleic acids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Isolation and characterization of the major serum albumin adduct formed by aflatoxin B1 in vivo in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Chemical and physical properties of the major serum albumin adduct of aflatoxin B1 and their implications for the quantification in biological samples

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

3-Phenylpropenes as mechanism-based inhibitors of dopamine beta-hydroxylase: evidence for a radical mechanism.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Dopamine-B-hydroxylase: suicide inhibition by the novel olefinic substrate, 1-phenyl-1-aminomethylethene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Haloalkene oxidation by the soluble methane monooxygenase from Methylosinus trichosporium OB3b: mechanistic and environmental implications.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

The chemical and biological versatility of riboflavin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Identification in the calcineurin A subunit of the domain that binds the regulatory B subunit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Binding of polycyclic hydrocarbons to nuclear components in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Inhibition of binding of benzo(a)pyrene metabolites to nuclear DNA by glutathione and glutathione S-transferase B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Metabolism of benzo(a)pyrene by isolated hepatocytes and factors affecting covalent binding of benzo(a)pyrene metabolites to DNA in hepatocyte and microsomal systems

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

Enzymatic activation of chemicals to toxic metabolites.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900415-0

10.1016/S0003-9861(02)00415-0

7 January 2021

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

4247937

4247937

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference