A possible role of acrolein in diabetic retinopathy: involvement of a VEGF/TGFβ signaling pathway of the retinal pigment epithelium in hyperglycemia (Q28647896)

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English	A possible role of acrolein in diabetic retinopathy: involvement of a VEGF/TGFβ signaling pathway of the retinal pigment epithelium in hyperglycemia	scientific article

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scholarly article

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A possible role of acrolein in diabetic retinopathy: involvement of a VEGF/TGFβ signaling pathway of the retinal pigment epithelium in hyperglycemia (English)

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sensory nervous system

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1 reference

based on heuristic

inferred from title

diabetic retinopathy

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based on heuristic

inferred from title

author name string

Jeffery Grigsby

1

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Brandi Betts

2

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Eileen Vidro-Kotchan

3

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Richard Culbert

4

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Andrew Tsin

5

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language of work or name

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publication date

November 2012

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Current Eye Research

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37

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1045-53

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11

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ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease

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SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

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Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542

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Biochemistry and molecular cell biology of diabetic complications

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17 March 2017

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

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Pigment epithelium-derived factor: a potent inhibitor of angiogenesis

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Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture

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Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

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Ginsenoside-Rb1 Induces ARPE-19 Proliferation and Reduces VEGF Release

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Effects of tamoxifen versus raloxifene on retinal capillary endothelial cell proliferation

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NBHA reduces acrolein-induced changes in ARPE-19 cells: possible involvement of TGFβ.

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3 June 2018

Evidence supporting a role for N-(3-formyl-3,4-dehydropiperidino)lysine accumulation in Müller glia dysfunction and death in diabetic retinopathy

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3 June 2018

Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction

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3 June 2018

The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier--implications for the pathogenesis of diabetic retinopathy.

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3 June 2018

α-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells

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Acrolein, a ubiquitous pollutant and lipid hydroperoxide product, inhibits antiviral activity of interferon-alpha: relevance to hepatitis C.

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3 June 2018

Acrolein-derived DNA adduct formation in human colon cancer cells: its role in apoptosis induction by docosahexaenoic acid

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Acrolein toxicity: Comparison with reactive oxygen species

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Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease

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Molecular mechanisms of the conjugated alpha,beta-unsaturated carbonyl derivatives: relevance to neurotoxicity and neurodegenerative diseases

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3 June 2018

Quantitation of acrolein-derived (3-hydroxypropyl)mercapturic acid in human urine by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: effects of cigarette smoking

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Estimating risk from ambient concentrations of acrolein across the United States.

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3 June 2018

The concept of "aldehyde load" in neurodegenerative mechanisms: cytotoxicity of the polyamine degradation products hydrogen peroxide, acrolein, 3-aminopropanal, 3-acetamidopropanal and 4-aminobutanal in a retinal ganglion cell line

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Survival signaling in retinal pigment epithelial cells in response to oxidative stress: significance in retinal degenerations

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3 June 2018

Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid

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ARPE-19 cell growth and cell functions in euglycemic culture media

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Antioxidants reduce cone cell death in a model of retinitis pigmentosa

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Bone morphogenetic protein-4 enhances vascular endothelial growth factor secretion by human retinal pigment epithelial cells

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Polyamine oxidase and acrolein as novel biochemical markers for diagnosis of cerebral stroke.

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Regulation mechanisms of retinal pigment epithelial cell migration by the TGF-beta superfamily

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Increase in putrescine, amine oxidase, and acrolein in plasma of renal failure patients.

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Metabolism and distribution of [2,3-14C]acrolein in Sprague-Dawley rats. II. Identification of urinary and fecal metabolites.

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Formation of cyclic 1,N2-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde

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Evaluation of N (epsilon)-(3-formyl-3,4-dehydropiperidino)lysine as a novel biomarker for the severity of diabetic retinopathy

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Formation of advanced glycosylation end products and oxidative stress in young patients with type 1 diabetes

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Increased Urinary Levels of Pentosidine, Pyrraline and Acrolein Adduct in Type 2 Diabetes

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Serum protein acrolein adducts: utility in detecting oxidant stress in hemodialysis patients and reversal using a vitamin E-bonded hemodialyzer

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Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease

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Resveratrol protects human retinal pigment epithelial cells from acrolein-induced damage

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Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).

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Role of TGF-beta in the retinoic acid-induced inhibition of proliferation and melanin synthesis in chick retinal pigment epithelial cells in vitro

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Lipid peroxidation products inhibit dopamine catabolism yielding aberrant levels of a reactive intermediate.

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Diabetes impairs the enzymatic disposal of 4-hydroxynonenal in rat liver.

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Transforming growth factor beta 2 is the predominant isoform in the neural retina, retinal pigment epithelium-choroid and vitreous of the monkey eye

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Synthesized TGF-beta s in RPE regulates cellular proliferation

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Apoptosis in proliferative vitreoretinal disorders: possible involvement of TGF-beta-induced RPE cell apoptosis.

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Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression

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Increased NADH oxidase activity in the retina of the BBZ/Wor diabetic rat

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10.3109/02713683.2012.713152

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