Perspectives on validation of high-throughput assays supporting 21st century toxicity testing (Q28658651)

12

Christopher Austin

0 references

Weida Tong

17

Weida Tong

0 references

Thomas Hartung

14

Thomas Hartung

0 references

Robert Kavlock

2

Robert Kavlock

0 references

David J. Dix

18

David Dix

0 references

Richard S. Judson

1

Richard Judson

0 references

Ann M Richard

7

Ann Richard

0 references

author name string

Matthew Martin

3

0 references

David Reif

4

0 references

Keith Houck

5

0 references

Thomas Knudsen

6

0 references

Raymond R Tice

8

0 references

Maurice Whelan

9

0 references

Menghang Xia

10

0 references

Ruili Huang

11

0 references

George Daston

13

0 references

John R Fowle

15

0 references

William Wooge

ALTEX: Alternatives to Animal Experimentation

16

0 references

language of work or name

English

0 references

publication date

2013

0 references

published in

0 references

volume

30

0 references

issue

1

0 references

page(s)

51-6

0 references

cites work

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

IPCS framework for analyzing the relevance of a noncancer mode of action for humans

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Minimum information about a microarray experiment (MIAME)-toward standards for microarray data

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

QSAR applicabilty domain estimation by projection of the training set descriptor space: a review

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Current status of methods for defining the applicability domain of (quantitative) structure-activity relationships. The report and recommendations of ECVAM Workshop 52

9 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Automation of an in vitro cytotoxicity assay used to estimate starting doses in acute oral systemic toxicity tests

9 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

BioAssay Ontology (BAO): a semantic description of bioassays and high-throughput screening results

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

BioAssay ontology annotations facilitate cross-analysis of diverse high-throughput screening data sets

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Food for thought ... considerations and guidelines for basic test method descriptions in toxicology.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Validation of innovative technologies and strategies for regulatory safety assessment methods: challenges and opportunities

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

The EDKB: an established knowledge base for endocrine disrupting chemicals

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

The toxicity data landscape for environmental chemicals

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Genetic and environmental pathways to complex diseases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

A toxicology for the 21st century--mapping the road ahead

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Toxicogenomics: transcription profiling for toxicology assessment.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Toxicity testing in the 21st century: implications for human health risk assessment

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

A specific mechanism for nonspecific activation in reporter-gene assays

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Fluorescence spectroscopic profiling of compound libraries

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Toxicology. Transforming environmental health protection

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma and quantitative analysis of in vivo induction pathway

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

The ToxCast program for prioritizing toxicity testing of environmental chemicals

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity data

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Applications of emerging technologies in toxicology and safety assessment

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

A modular approach to the ECVAM principles on test validity.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

A framework for human relevance analysis of information on carcinogenic modes of action

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Exploiting genome data to understand the function, regulation, and evolutionary origins of toxicologically relevant genes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

ICCVAM evaluation of the murine local lymph node assay. The ICCVAM review process

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Recombinant cell bioassays for endocrine disruptors: development of a stably transfected human ovarian cell line for the detection of estrogenic and anti-estrogenic chemicals.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Microarrays and toxicology: the advent of toxicogenomics

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

The principles of good laboratory practice: application to in vitro toxicology studies.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Safety testing: moving toward alternative methods.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Chemical target and pathway toxicity mechanisms defined in primary human cell systems

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Food for thought... on evidence-based toxicology.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Framework for use of toxicity screening tools in context-based decision-making

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Meeting the scientific needs of ecological risk assessment in a regulatory context.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934015

Gene expression analysis reveals chemical-specific profiles

27 November 2018

1 reference

12 December 2020

Food for thought ... on validation

1 reference

12 December 2020

ECVAM's approach to intellectual property rights in the validation of alternative methods

1 reference

12 December 2020

Toxicity testing in the 21st century: a vision and a strategy.

1 reference

12 December 2020

10.14573/ALTEX.2013.1.051

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

23338806

1 reference