Porphobilinogen deaminase and uroporphyrinogen III synthase: Structure, molecular biology, and mechanism (Q28678722)

31 May 2024

0 references

P. M. Shoolingin-Jordan

1

1 reference

6 February 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

PubMed ID

7592565

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=7592565

full work available at URL

31 May 2024

publication date

1 April 1995

1 reference

6 February 2017

http://link.springer.com/content/pdf/10.1007/BF02110033.pdf

file format

Portable Document Format

1 reference

http://link.springer.com/article/10.1007/BF02110033/fulltext.html

31 May 2024

1 reference

http://link.springer.com/content/pdf/10.1007/BF02110033

31 May 2024

1 reference

Journal of Bioenergetics and Biomembranes

31 May 2024

published in

1 reference

6 February 2017

27

1 reference

6 February 2017

2

1 reference

6 February 2017

181–195

1 reference

6 February 2017

Purification and properties of uroporphyrinogen III synthase (co-synthase) from an overproducing recombinant strain of Escherichia coli K-12

1 reference

https://api.crossref.org/works/10.1007%2FBF02110033

Polypyrroles formed from porphobilinogen and amines by uroporphyrinogen synthetase of Rhodopseudomonas spheroides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02110033

Investigation of putative active-site lysine residues in hydroxymethylbilane synthase. Preparation and characterization of mutants in which (a) Lys-55, (b) Lys-59 and (c) both Lys-55 and Lys-59 have been replaced by glutamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02110033

Purification and properties of uroporphyrinogen III synthase (co-synthetase) from Euglena gracilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02110033

Modification of hydroxymethylbilane synthase (porphobilinogen deaminase) by pyridoxal 5'-phosphate. Demonstration of an essential lysine residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02110033

Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound through the sulphur atom of a cysteine residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02110033

Purification and properties of porphobilinogen deaminase from Arabidopsis thaliana

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02110033

Mechanism of action of porphobilinogen deaminase. The participation of stable enzyme substrate covalent intermediates between porphobilinogen and the porphobilinogen deaminase from Rhodopseudomonas spheroides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02110033

Mutagenesis of arginine residues in the catalytic cleft of Escherichia coli porphobilinogen deaminase that affects dipyrromethane cofactor assembly and tetrapyrrole chain initiation and elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02110033

Purification, crystallization and properties of porphobilinogen deaminase from a recombinant strain of Escherichia coli K12

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02110033

Nucleotide sequence for the hemD gene of Escherichia coli encoding uroporphyrinogen III synthase and initial evidence for a hem operon

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02110033

Rat hepatic uroporphyrinogen III co-synthase. Purification and evidence for a bound folate coenzyme participating in the biosynthesis of uroporphyrinogen III

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02110033

Studies on the mechanism of hydroxymethylbilane synthase concerning the role of arginine residues in substrate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02110033

Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound to the protein through the sulphur atom of cysteine-242.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02110033

Rat liver uroporphyrinogen III synthase has similar properties to the enzyme from Euglena gracilis, including absence of a requirement for a reversibly bound cofactor for activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02110033

Purification of porphobilinogen deaminase from Euglena gracilis and studies of its kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02110033

Rat porphobilinogen deaminase cDNA: nucleotide sequence of the erythropoletic form

21 January 2018

1 reference

12 December 2020

Structure and regulation of yeast HEM3, the gene for porphobilinogen deaminase

1 reference

12 December 2020

Molecular cloning and complete primary sequence of human erythrocyte porphobilinogen deaminase

1 reference

12 December 2020

The mouse porphobilinogen deaminase gene. Structural organization, sequence, and transcriptional analysis.

1 reference

12 December 2020

The isolation and characterization of catalytically competent porphobilinogen deaminase-intermediate complexes

1 reference

12 December 2020

The Bacillus subtilis hemAXCDBL gene cluster, which encodes enzymes of the biosynthetic pathway from glutamate to uroporphyrinogen III

1 reference

12 December 2020

The synthesis of stereoselectively labelled porphobilinogen and its incorporation into protoporphyrin-IX

1 reference

12 December 2020

Site-directed mutagenesis and high-resolution NMR spectroscopy of the active site of porphobilinogen deaminase.

1 reference

12 December 2020

Biosynthesis of uroporphyrinogens. Interaction among 2-(aminomethyl)bilanes and the enzymatic system

1 reference

12 December 2020

Structure of porphobilinogen deaminase reveals a flexible multidomain polymerase with a single catalytic site

1 reference

12 December 2020

The three-dimensional structures of mutants of porphobilinogen deaminase: toward an understanding of the structural basis of acute intermittent porphyria

1 reference

12 December 2020

The enzymatic synthesis of porphyrins from porphobilinogen. I. Uroporphyrin I

1 reference

12 December 2020

Reconstitution of apo-porphobilinogen deaminase: structural changes induced by cofactor binding

1 reference

12 December 2020

Purification and properties of uroporphyrinogen III synthase from human erythrocytes

1 reference

12 December 2020

The biosynthesis of uroporphyrinogen III: Order of assembly of the four porphobilinogen molecules in the formation of the tetrapyrrole ring

1 reference

12 December 2020

Evidence for participation of aspartate-84 as a catalytic group at the active site of porphobilinogen deaminase obtained by site-directed mutagenesis of the hemC gene from Escherichia coli

1 reference

12 December 2020

19-Bromo-1-hydroxymethylbilane, a novel inhibitor of uro'gen III synthase

1 reference

12 December 2020

Isolation and characterisation of a cDNA clone for a chlorophyll synthesis enzyme from Euglena gracilis. The chloroplast enzyme hydroxymethylbilane synthase (porphobilinogen deaminase) is synthesised with a very long transit peptide in Euglena

1 reference

12 December 2020

Evidence for an intermediate in the enzymatic formation of uroporphyrinogen III.

1 reference

12 December 2020

Human uroporphyrinogen III synthase: molecular cloning, nucleotide sequence, and expression of a full-length cDNA

1 reference

12 December 2020

The Pseudomonas aeruginosa homologs of hemC and hemD are linked to the gene encoding the regulator of mucoidy AlgR.

1 reference

12 December 2020

Nucleotide sequence of the hemC locus encoding porphobilinogen deaminase of Escherichia coli K12.

1 reference

12 December 2020

Purification and Properties of Uroporphyrinogen I Synthetase from Rhodopseudomonas spheroides

1 reference

12 December 2020

Investigation into the nature of substrate binding to the dipyrromethane cofactor of Escherichia coli porphobilinogen deaminase.

1 reference

12 December 2020

A tetrapyrrylmethane intermediate in the enzymatic synthesis of uroporphyrinogen

1 reference

12 December 2020

Uroporphyrinogen III cosynthetase: a direct assay method

1 reference

12 December 2020

Evidence for a dipyrromethane cofactor at the catalytic site of E. coli porphobilinogen deaminase

1 reference

12 December 2020

The purification and properties of uroporphyrinogen I synthases and uroporphyrinogen III cosynthase. Interactions between the enzymes

1 reference

12 December 2020

Nucleotide sequence of hemD, the second gene in the hem operon of Escherichia coli K-12.

1 reference

12 December 2020

Biosynthesis of uroporphyrinogens from porphobilinogen: mechanism and the nature of the process

1 reference

12 December 2020

Molecular cloning and sequencing of the hemD gene of Escherichia coli K-12 and preliminary data on the Uro operon

1 reference

12 December 2020

Biosynthesis of porphyrins and corrins

1 reference

12 December 2020

Purification and properties of uroporphyrinogen I synthase from human erythrocytes. Identification of stable enzyme-substrate intermediates

1 reference

12 December 2020

Heterogeneity of mutations in the uroporphyrinogen III synthase gene in congenital erythropoietic porphyria

1 reference

12 December 2020

Identification of a cysteine residue as the binding site for the dipyrromethane cofactor at the active site of Escherichia coli porphobilinogen deaminase.

1 reference

12 December 2020

Cloning and characterization of the hemA region of the Bacillus subtilis chromosome

1 reference

12 December 2020

Preuroporphyrinogen, a universal intermediate in the biosynthesis of uroporphyrinogen III

1 reference

12 December 2020

Biosynthesis of uroporphyrinogens. Interaction among 2-aminomethyldipyrrylmethanes and the enzymic system

1 reference

12 December 2020

Transferrins: insights into structure and function from studies on lactoferrin

4

1 reference

On the mechanism of porphobilinogen deaminase. Design, synthesis, and enzymatic reactions of novel porphobilinogen analogs

31 May 2024

75

1 reference

Biosynthesis of porphyrins and related macrocycles. Part 40. Synthesis of a spiro-lactam related to the proposed spiro-intermediate for porphyrin biosynthesis: inhibition of cosynthetase

31 May 2024

91

1 reference

Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver

31 May 2024

95

1 reference