Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu (Q28678768)

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

The neu oncogene encodes an epidermal growth factor receptor-related protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Molecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Oral cancer progression and c-erbB-2/neu proto-oncogene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Ligand and p185c-neu density govern receptor interactions and tyrosine kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Direct interaction of a ligand for the erbB2 oncogene product with the EGF receptor and p185erbB2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Identification of heregulin, a specific activator of p185erbB2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Neu differentiation factor: a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Regulatory mechanisms for ras proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Association between GRB2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for Ras activation by insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Multiple cis- and trans-acting elements involved in regulation of the neu gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Mechanistic aspects of signaling through Ras in NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Protein modules and signalling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717

Neu receptor dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.51.30717