Fundamentals of FGF19 &amp; FGF21 action in vitro and in vivo (Q28729024)

1

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Tamer Coskun

2

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Armando R Irizarry Rovira

3

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Michael A Schneider

4

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David W Raches

5

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Radmila Micanovic

6

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Holly A Bina

7

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James D Dunbar

Creative Commons Attribution 4.0 International

8

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language of work or name

English

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publication date

2012

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published in

PLOS One

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volume

7

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issue

5

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page(s)

e38438

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copyright license

start time

31 May 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Different roles of N- and C- termini in the functional activity of FGF21

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betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c

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Klotho converts canonical FGF receptor into a specific receptor for FGF23

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A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice

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Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states

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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

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Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands

7 April 2017

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A unique FGF23 with the ability to activate FGFR signaling through both αKlotho and βKlotho

20 June 2018

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Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance

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20 June 2018

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Relevant use of Klotho in FGF19 subfamily signaling system in vivo

20 June 2018

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FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation

20 June 2018

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A very low carbohydrate ketogenic diet improves glucose tolerance in ob/ob mice independently of weight loss

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Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice

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20 June 2018

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Resistance to chemotherapy is associated with fibroblast growth factor receptor 4 up-regulation

20 June 2018

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The Klotho gene family as a regulator of endocrine fibroblast growth factors

20 June 2018

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Fibroblast growth factor 21 corrects obesity in mice

20 June 2018

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Fibroblast growth factor-21 as a therapeutic agent for metabolic diseases

20 June 2018

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FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho

20 June 2018

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Co-receptor requirements for fibroblast growth factor-19 signaling

20 June 2018

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Fibroblast growth factors as regulators of stem cell self-renewal and aging

20 June 2018

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Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365001

Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes.

20 June 2018

1 reference

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Fibroblast growth factors, fibroblast growth factor receptors, diseases, and drugs

20 June 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22675463

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Best practices guideline: toxicologic histopathology

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22675463

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0038438

1 reference

373133

ADS bibcode

2012PLoSO...738438A

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373133

1 reference

1 reference

1 reference