TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma (Q28740616)

2

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Thomas D Wu

3

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Johnny Gutierrez

4

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J Michael Elliott

5

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Jean-Michel Vernes

6

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Hartmut Koeppen

7

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Heidi S Phillips

8

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Frederic J de Sauvage

9

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Y Gloria Meng

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

10

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language of work or name

English

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publication date

29 April 2011

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published in

PLOS One

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volume

6

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issue

4

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page(s)

e18608

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cites work

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Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma

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DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers

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Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma

17 March 2017

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Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas

17 March 2017

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TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence

17 March 2017

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HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers

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The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells

27 November 2018

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Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons

17 March 2017

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A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells

17 March 2017

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Mechanism of action and in vivo role of platelet-derived growth factor

17 March 2017

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Follistatin: a multifunctional regulatory protein

17 March 2017

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A simple method for displaying the hydropathic character of a protein

17 March 2017

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cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules

17 March 2017

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cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor

17 March 2017

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Two different subunits associate to create isoform-specific platelet-derived growth factor receptors

17 March 2017

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The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors

17 March 2017

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Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

17 March 2017

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Genome-wide DNA methylation profiling using Infinium® assay

7 April 2017

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Molecular subclassification of diffuse gliomas: seeing order in the chaos

3 June 2018

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Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations

3 June 2018

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Recent insights into PDGF-induced gliomagenesis

3 June 2018

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Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib

3 June 2018

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Arming antibodies for cancer therapy

3 June 2018

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Aberrant methylation profile of human malignant mesotheliomas and its relationship to SV40 infection.

3 June 2018

1 reference

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Methylation patterns define two types of hyperplastic polyp associated with colorectal cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084709

Tomoregulin-1 (TMEFF1) inhibits nodal signaling through direct binding to the nodal coreceptor Cripto.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084709

Roles of PDGF in animal development

3 June 2018

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Tomoregulin ectodomain shedding by proinflammatory cytokines

3 June 2018

1 reference

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PDGFRA activating mutations in gastrointestinal stromal tumors.

3 June 2018

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TMEFF2 is an androgen-regulated gene exhibiting antiproliferative effects in prostate cancer cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084709

Identification of differentially expressed genes associated with androgen-independent growth of prostate cancer

3 June 2018

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PDGF-AB requires PDGF receptor alpha-subunits for high-affinity, but not for low-affinity, binding and signal transduction.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084709

Functions of agrin and agrin-related proteins

3 June 2018

1 reference

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A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro

3 June 2018

1 reference

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Structural and functional aspects of the receptors for platelet-derived growth factor

3 June 2018

1 reference

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Platelet-derived growth factor and its role in health and disease

3 June 2018

1 reference

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Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084709

Correlation of hMLH1 and HPP1 hypermethylation in gastric, but not in esophageal and cardiac adenocarcinoma

3 June 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018608

Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis.

21 January 2018

1 reference

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SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018608

Regulation of nodal and BMP signaling by tomoregulin-1 (X7365) through novel mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018608

A truncated isoform of TMEFF2 encodes a secreted protein in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018608

Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis

21 January 2018

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Use of DNA from human stools to detect aberrant CpG island methylation of genes implicated in colorectal cancer.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084709

Preclinical validation of anti-TMEFF2-auristatin E-conjugated antibodies in the treatment of prostate cancer.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084709

Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084709

Platelet-derived growth factor A and B chains and the alpha and beta receptors in prostatic intraepithelial neoplasia

27 November 2018

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PubMed

12 December 2020

Prognostic value of platelet-derived growth factor-A (PDGF-A) in gastric carcinoma

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PubMed

12 December 2020

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12 December 2020

Immunohistochemistry analysis of platelet-derived growth factor A and B chains and platelet-derived growth factor alpha and beta receptor expression in benign prostatic hyperplasias and Gleason-graded human prostate adenocarcinomas

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PubMed

12 December 2020