Exposure-response of 1,2:3,4-diepoxybutane-specific N-terminal valine adducts in mice and rats after inhalation exposure to 1,3-butadiene (Q28752155)

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Gunnar Boysen

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Narisa Bordeerat

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James A Swenberg

Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke

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language of work or name

English

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publication date

June 2010

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published in

Toxicological Sciences

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115

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issue

2

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page(s)

322-9

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cites work

1 reference

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Molecular dosimetry of 1,2,3,4-diepoxybutane-induced DNA-DNA cross-links in B6C3F1 mice and F344 rats exposed to 1,3-butadiene by inhalation

3 June 2018

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Quantitative high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry analysis of the adenine-guanine cross-links of 1,2,3,4-diepoxybutane in tissues of butadiene-exposed B6C3F1 mice

3 June 2018

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Biomarkers in toxicology and risk assessment: informing critical dose-response relationships

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Identification of covalent modifications in P450 2E1 by 1,2-epoxy-3-butene in vitro

3 June 2018

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N-terminal globin adducts as biomarkers for formation of butadiene derived epoxides.

3 June 2018

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Mutagenicity of stereochemical configurations of 1,2-epoxybutene and 1,2:3,4-diepoxybutane in human lymphblastoid cells

3 June 2018

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Cancer risk assessment for 1,3-butadiene: data integration opportunities

3 June 2018

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Analysis of diepoxide-specific cyclic N-terminal globin adducts in mice and rats after inhalation exposure to 1,3-butadiene

3 June 2018

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Protein adducts: quantitative and qualitative aspects of their formation, analysis and applications

3 June 2018

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Using DNA and hemoglobin adducts to improve the risk assessment of butadiene

3 June 2018

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Toxicology and epidemiology of 1,3-butadiene

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Mechanism-based inactivation of cytochromes P450 2E1 and 2E1 T303A by tert-butyl acetylenes: characterization of reactive intermediate adducts to the heme and apoprotein

3 June 2018

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Dose responses for the formation of hemoglobin adducts and urinary metabolites in rats and mice exposed by inhalation to low concentrations of 1,3-[2,3-(14)C]-butadiene

21 January 2018

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Evaluation of cancer tests of 1,3-butadiene using internal dose, genotoxic potency, and a multiplicative risk model

21 January 2018

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Synthesis and characterization of peptides containing a cyclic Val adduct of diepoxybutane, a possible biomarker of human exposure to butadiene

21 January 2018

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A liquid chromatography tandem mass spectrometric method for in vivo dose monitoring of diepoxybutane, a metabolite of butadiene.

21 January 2018

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Ratios of N-(2,3,4-trihydroxybutyl) valine and N-(2-hydroxy-3-butenyl) valine formed hemoglobin adducts in female mice inhalation exposure with 1,3-butadiene

21 January 2018

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Differential modulation of CYP2E1 activity by cAMP-dependent protein kinase upon Ser129 replacement.

21 January 2018

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Quantification of DNA and hemoglobin adducts of 3,4-epoxy-1,2-butanediol in rodents exposed to 3-butene-1,2-diol

21 January 2018

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IARC monographs on the evaluation of carcinogenic risks to humans. Volume 97. 1,3-butadiene, ethylene oxide and vinyl halides (vinyl fluoride, vinyl chloride and vinyl bromide).

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Mutagenicity at the Hprt locus in T cells of female mice following inhalation exposures to low levels of 1,3-butadiene

27 November 2018

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Molecular dosimetry of ethylene oxide: formation and persistence of N-(2-hydroxyethyl)valine in hemoglobin following repeated exposures of rats and mice

27 November 2018

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12 December 2020

1,3-butadiene: cancer, mutations, and adducts. Part V: Hemoglobin adducts as biomarkers of 1,3-butadiene exposure and metabolism

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12 December 2020

Metabolism of 3-butene-1,2-diol in B6C3F1 mice. Evidence for involvement of alcohol dehydrogenase and cytochrome p450

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12 December 2020

Monitoring of environmental cancer initiators through hemoglobin adducts by a modified Edman degradation method

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12 December 2020

Oxidation of butadiene monoxide to meso- and (+/-)-diepoxybutane by cDNA-expressed human cytochrome P450s and by mouse, rat, and human liver microsomes: evidence for preferential hydration of meso-diepoxybutane in rat and human liver microsomes

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12 December 2020

HPLC-ESI+-MS/MS analysis of N7-guanine-N7-guanine DNA cross-links in tissues of mice exposed to 1,3-butadiene

1 reference

12 December 2020

Molecular dosimetry of N-7 guanine adduct formation in mice and rats exposed to 1,3-butadiene

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12 December 2020

1,3-butadiene: cancer, mutations, and adducts. Part III: In vivo mutation of the endogenous hprt genes of mice and rats by 1,3-butadiene and its metabolites

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12 December 2020

Oxidation of 1,2-epoxy-3-butene to 1,2:3,4-diepoxybutane by cDNA-expressed human cytochromes P450 2E1 and 3A4 and human, mouse and rat liver microsomes

1 reference

12 December 2020