LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin (Q28757894)

1

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Kristin K Jernigan

2

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Emilios Tahinci

3

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Curtis A Thorne

4

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Laura A Lee

5

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Ethan Lee

Proceedings of the National Academy of Sciences of the United States of America

6

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language of work or name

English

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publication date

10 June 2008

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published in

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volume

105

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issue

23

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page(s)

8032-7

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cites work

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Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling

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The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity

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Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction

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Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

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A mechanism for Wnt coreceptor activation

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The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway

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Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

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Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled

16 March 2017

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Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

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An LDL-receptor-related protein mediates Wnt signalling in mice

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Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex

16 March 2017

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Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

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Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability

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arrow encodes an LDL-receptor-related protein essential for Wingless signalling

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Plasma membrane recruitment of dephosphorylated beta-catenin upon activation of the Wnt pathway.

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Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins

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Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination

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3 June 2018

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wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo.

3 June 2018

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Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

3 June 2018

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Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity

3 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0803025105

Wnt11/beta-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0803025105

Regulated proteolytic processing of LRP6 results in release of its intracellular domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0803025105

Pin1 acts catalytically to promote a conformational change in Cdc25.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0803025105

Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0803025105

21 January 2018

Relays at the membrane

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0803025105

Light-dependent cleavage of the gamma subunit of coupling factor 1 by trypsin causes activation of Mg2+-ATPase activity and uncoupling of photophosphorylation in spinach chloroplasts

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18509060

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18509060

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0803025105

1 reference

879746

ADS bibcode

2008PNAS..105.8032C

0 references

879746

1 reference

1 reference

1 reference