Steroids, triterpenoids and molecular oxygen (Q28767416)

1

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Alexander S Bradley

2

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Linda L Jahnke

3

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Jacob R Waldbauer

Philosophical Transactions of the Royal Society B

4

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language of work or name

English

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publication date

29 June 2006

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published in

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volume

361

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issue

1470

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page(s)

951-68

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cites work

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Crystal structure of cytochrome P450 14 -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors

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Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase

16 March 2017

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Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation

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Archean Molecular Fossils and the Early Rise of Eukaryotes

16 March 2017

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Identification, characterization, and partial purification of 4 alpha-carboxysterol-C3-dehydrogenase/ C4-decarboxylase from Zea mays

16 March 2017

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Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis

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Structure and function of a squalene cyclase

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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

16 March 2017

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Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme as a case of horizontal gene transfer

16 March 2017

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Molecular evolution of biomembranes: structural equivalents and phylogenetic precursors of sterols

16 March 2017

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Membrane curvature and mechanisms of dynamic cell membrane remodelling

16 March 2017

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Transcriptional regulation of phagocytosis-induced membrane biogenesis by sterol regulatory element binding proteins

7 April 2017

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Enzyme mechanisms for triterpene cyclization: new pieces of the puzzle

3 June 2018

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Lipid traffic: floppy drives and a superhighway.

3 June 2018

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Sterol structure determines the separation of phases and the curvature of the liquid-ordered phase in model membranes

3 June 2018

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Protons may leak through pure lipid bilayers via a concerted mechanism

3 June 2018

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Oxidosqualene cyclase second-sphere residues profoundly influence the product profile

3 June 2018

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Root of the Eukaryota tree as inferred from combined maximum likelihood analyses of multiple molecular sequence data

3 June 2018

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Biosynthesis and accumulation of sterols

3 June 2018

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Mechanism of oxidation reactions catalyzed by cytochrome p450 enzymes.

3 June 2018

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Fluconazole binding and sterol demethylation in three CYP51 isoforms indicate differences in active site topology

3 June 2018

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CYP51--the omnipotent P450.

3 June 2018

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Dating the rise of atmospheric oxygen

3 June 2018

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Plant sterol biosynthesis: identification of two distinct families of sterol 4alpha-methyl oxidases

3 June 2018

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Sterols in microorganisms

3 June 2018

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Steroid biosynthesis in prokaryotes: identification of myxobacterial steroids and cloning of the first bacterial 2,3(S)-oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca

3 June 2018

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A novel sterol 14alpha-demethylase/ferredoxin fusion protein (MCCYP51FX) from Methylococcus capsulatus represents a new class of the cytochrome P450 superfamily

3 June 2018

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Do sterols reduce proton and sodium leaks through lipid bilayers?

3 June 2018

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Isotopic evidence for microbial sulphate reduction in the early Archaean era.

3 June 2018

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Evolution. When did photosynthesis emerge on Earth?

3 June 2018

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Atmospheric influence of Earth's earliest sulfur cycle

3 June 2018

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Evidence of atmospheric sulphur in the martian regolith from sulphur isotopes in meteorites.

3 June 2018

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Biomarker evidence for widespread anaerobic methane oxidation in Mediterranean sediments by a consortium of methanogenic archaea and bacteria. The Medinaut Shipboard Scientific Party

3 June 2018

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Theoretical investigation of the [1,2]-sigmatropic hydrogen migration in the mechanism of oxidation of 2-aminobenzoyl-CoA by 2-aminobenzoyl-CoA monooxygenase/reductase

3 June 2018

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Occurrence of a P450 showing high homology to yeast lanosterol 14-demethylase (P450(14DM)) in the rat liver

3 June 2018

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Oxygen requirements for formation and activity of the squalene epoxidase in Saccharomyces cerevisiae

3 June 2018

1 reference

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Sterol structure and membrane function

3 June 2018

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Sterol biosynthesis via cycloartenol and other biochemical features related to photosynthetic phyla in the amoeba Naegleria lovaniensis and Naegleria gruberi

3 June 2018

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3 June 2018

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Prokaryotic hopanoids and other polyterpenoid sterol surrogates

3 June 2018

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Secondary structure prediction of 52 membrane-bound cytochromes P450 shows a strong structural similarity to P450cam

3 June 2018

1 reference

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A phylogenetic analysis of the myxobacteria: basis for their classification

3 June 2018

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Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells

3 June 2018

1 reference

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Iron Isotope Constraints on the Archean and Paleoproterozoic Ocean Redox State

27 November 2018

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Photosynthetic microbial mats in the 3,416-Myr-old ocean

27 November 2018

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New aspects on lanosterol 14alpha-demethylase and cytochrome P450 evolution: lanosterol/cycloartenol diversification and lateral transfer

27 November 2018

1 reference

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CYP51 from Trypanosoma brucei is obtusifoliol-specific

27 November 2018

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Photoaffinity labeling identifies the substrate-binding site of mammalian squalene epoxidase

27 November 2018

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ABSENCE OF STEROLS IN BLUE-GREEN ALGAE.

27 November 2018

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Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2).

27 November 2018

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Enzymological properties of sterol-C4-methyl-oxidase of yeast sterol biosynthesis.

27 November 2018

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Directed evolution experiments reveal mutations at cycloartenol synthase residue His477 that dramatically alter catalysis

27 November 2018

1 reference

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Directed evolution to generate cycloartenol synthase mutants that produce lanosterol

27 November 2018

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Substrate recognition sites in 14alpha-sterol demethylase from comparative analysis of amino acid sequences and X-ray structure of Mycobacterium tuberculosis CYP51.

27 November 2018

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Cloning and functional characterization of a Trypanosoma brucei lanosterol 14alpha-demethylase gene.

27 November 2018

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Oxidant abundances in rainwater and the evolution of atmospheric oxygen

27 November 2018

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A paleoweathering profile from Griqualand West, South Africa: evidence for a dramatic rise in atmospheric oxygen between 2.2 and 1.9 bybp

27 November 2018

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Carbon isotope evidence for the stepwise oxidation of the Proterozoic environment

27 November 2018

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Enzyme Mechanisms for Polycyclic Triterpene Formation

27 November 2018

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2-Methylhopanoids as biomarkers for cyanobacterial oxygenic photosynthesis.

27 November 2018

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Sterols: Isolation from a Blue-Green Alga

27 November 2018

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Sterol Biosynthesis in Euglena gracilis Z.. Sterol Precursors in Light-Grown and Dark-Grown Euglena gracilis Z

27 November 2018

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12 December 2020

Photoaffinity labeling and site-directed mutagenesis of rat squalene epoxidase

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12 December 2020

The origin and evolution of oxygenic photosynthesis

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12 December 2020

Prokaryotic triterpenoids. 3. The biosynthesis of 2 beta-methylhopanoids and 3 beta-methylhopanoids of Methylobacterium organophilum and Acetobacter pasteurianus ssp. pasteurianus

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12 December 2020

Oxidosqualene Cyclase Residues that Promote Formation of Cycloartenol, Lanosterol, and Parkeol We are grateful to Bridget M. Joubert for advice regarding mutagenesis. We thank Elizabeth A. Hart for an authentic parkeol standard, and for chromatograp

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12 December 2020

Effect of alkyl-substituted precursors of cholesterol on artificial and natural membranes and on the viability of Mycoplasma capricolum

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12 December 2020

Gene descent, duplication, and horizontal transfer in the evolution of glutamyl- and glutaminyl-tRNA synthetases

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12 December 2020

The effects of growth temperature on the methyl sterol and phospholipid fatty acid composition of Methylococcus capsulatus (Bath)

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12 December 2020

[Sterols and their precursors in Astasia longa Pringsheim]

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12 December 2020

Steroids and Squalene in Methylococcus capsulatus grown on Methane

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12 December 2020

Identifiers

DOI

10.1098/RSTB.2006.1837

1 reference

520993

520993

1 reference

1 reference

1 reference