KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1 (Q28975621)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

title

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1 (English)

2 references

21 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference

Gene Ontology release 2020-05-02

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0140007

GATOR1 complex binding

1 reference

Gene Ontology release 2020-05-02

1 reference

SEH1 like nucleoporin

1 reference

NPR3 like, GATOR1 complex subunit

1 reference

SZT2 subunit of KICSTOR complex

1 reference

NPR2 like, GATOR1 complex subunit

1 reference

DEP domain containing 5, GATOR1 subcomplex subunit

1 reference

Integrin alpha FG-GAP repeat containing 2

1 reference

Chromosome 12 open reading frame 66

1 reference

Meiosis regulator for oocyte development

1 reference

Kaptin, actin binding protein

1 reference

SEC13 homolog, nuclear pore and COPII coat complex component

1 reference

WD repeat domain 59

1 reference

negative regulation of TORC1 signaling

1 reference

SZT2 subunit of KICSTOR complex

1 reference

author

David M. Sabatini

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

author name string

Lynne Chantranupong

2

2 references

21 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Xin Gu

4

2 references

21 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Kuang Shen

6

2 references

21 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Sabrina Petri

8

2 references

21 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Jibril Kedir

9

2 references

21 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Monther Abu-Remaileh

11

2 references

21 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Rachel L Wolfson

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Gregory A Wyant

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Jose M Orozco

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Kendall J Condon

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Sonia M Scaria

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Wayne N Frankel

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

language of work or name

English

0 references

publication date

15 February 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

2 references

21 March 2017

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2 April 2020

volume

543

2 references

21 March 2017

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2 April 2020

page(s)

438-442

1 reference

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2 April 2020

issue

7645

2 references

21 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function

2 April 2020

cites work

1 reference

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Mutations in KPTN cause macrocephaly, neurodevelopmental delay, and seizures

24 March 2017

1 reference

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Biallelic SZT2 mutations cause infantile encephalopathy with epilepsy and dysmorphic corpus callosum

24 March 2017

1 reference

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A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

24 March 2017

1 reference

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24 March 2017

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mTOR signaling in growth control and disease

24 March 2017

1 reference

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

24 March 2017

1 reference

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Szt2, a novel gene for seizure threshold in mice

24 March 2017

1 reference

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

24 March 2017

1 reference

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5360989

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5360989

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

7 April 2017

1 reference

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mTOR signaling pathway genes in focal epilepsies

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5360989

GATOR1 complex: the common genetic actor in focal epilepsies

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5360989

12q14 Microdeletions: Additional Case Series with Confirmation of a Macrocephaly Region

3 June 2018

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Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia

3 June 2018

1 reference

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TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5360989

The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila.

3 June 2018

1 reference

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The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5360989

Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5360989

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5360989

Amino acid signalling upstream of mTOR

3 June 2018

1 reference

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Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.

3 June 2018

1 reference

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mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

3 June 2018

1 reference

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mTOR: A pathogenic signaling pathway in developmental brain malformations

3 June 2018

1 reference

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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5360989

Early-life epileptic encephalopathy secondary to SZT2 pathogenic recessive variants.

3 June 2018

1 reference

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Novel homozygous mutation in KPTN gene causing a familial intellectual disability-macrocephaly syndrome

26 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE21423

inferred from DOI database lookup

7 January 2021

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Identifiers

2 references

21 March 2017

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Dimensions Publication ID

2 April 2020

1083821287

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Fatcat ID

release_436vp43agrfenicgr5agw7mewu

1 reference

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mapped directly with Wikidata item

24 November 2022

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1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28199306%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

2 references

21 March 2017