Nephron organoids derived from human pluripotent stem cells model kidney development and injury (Q29037394)

27 March 2017

1 reference

1 reference

5

M Todd Valerius

1 reference

27 March 2017

6

Joseph V Bonventre

1 reference

27 March 2017

author name string

Ryuji Morizane

1

1 reference

27 March 2017

Albert Q Lam

2

1 reference

27 March 2017

Benjamin S Freedman

3

1 reference

27 March 2017

Seiji Kishi

4

1 reference

27 March 2017

publication date

12 October 2015

1 reference

27 March 2017

1 reference

27 March 2017

volume

33

1 reference

27 March 2017

page(s)

1193-1200

1 reference

27 March 2017

issue

11

1 reference

describes a project that uses

27 March 2017

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4747858/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Cerebral organoids model human brain development and microcephaly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Laser capture-microarray analysis of Lim1 mutant kidney development

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Crucial roles of Brn1 in distal tubule formation and function in mouse kidney

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Requirement for Wnt3 in vertebrate axis formation

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Prevalence of chronic kidney disease in the United States

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Renal progenitors derived from human iPSCs engraft and restore function in a mouse model of acute kidney injury

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Nephron reconstitution from pluripotent stem cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Directed differentiation of pluripotent stem cells to kidney cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Differentiation of human pluripotent stem cells into nephron progenitor cells in a serum and feeder free system

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients with PKD1 mutations

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Kidney specific protein-positive cells derived from embryonic stem cells reproduce tubular structures in vitro and differentiate into renal tubular cells.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Analysis of nephric duct specification in the avian embryo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Differentiation of murine embryonic stem and induced pluripotent stem cells to renal lineage in vitro.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Intrinsic epithelial cells repair the kidney after injury

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Marked differences in differentiation propensity among human embryonic stem cell lines

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Mouse embryonic stem cell-derived embryoid bodies generate progenitors that integrate long term into renal proximal tubules in vivo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Developmental regulation of the Hox genes during axial morphogenesis in the mouse

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

A ureteric bud cell line induces nephrogenesis in two steps by two distinct signals

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747858

Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules.

3 June 2018

1 reference

Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epithelia

21 January 2018

1 reference

Human embryonic stem cells differentiate into functional renal proximal tubular-like cells.

21 January 2018

1 reference

Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells

21 January 2018

1 reference

Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney

21 January 2018

1 reference

BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway.

21 January 2018

1 reference

Collinear activation of Hoxb genes during gastrulation is linked to mesoderm cell ingression.

21 January 2018

1 reference

Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.

21 January 2018

1 reference

Acute Renal Failure in Critically Ill Patients A Multinational, Multicenter Study

21 January 2018

1 reference

12 December 2020

The relationship between enzymuria and kidney enzyme activities in experimental gentamicin nephrotoxicity

1 reference

12 December 2020

Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and Cavalieri principle

1 reference

12 December 2020

Metanephric mesenchyme contains multipotent stem cells whose fate is restricted after induction

1 reference

12 December 2020

Stage- and segment-specific expression of cell-adhesion molecules N-CAM, A-CAM, and L-CAM in the kidney

1 reference

12 December 2020

Identifiers

DOI

10.1038/NBT.3392

2 references

27 March 2017

Dimensions Publication ID

1330641

1027516503

0 references

1163211

1 reference

1163211

1330641

1 reference

1 reference

1 reference