Activity of Indenoisoquinolines against African Trypanosomes (Q29041290)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18824603%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

title

Activity of indenoisoquinolines against African trypanosomes (English)

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14 January 2020

1

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14 January 2020

author name string

Dongpei Sang

2

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14 January 2020

Andrew Morrell

3

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14 January 2020

Mark Cushman

4

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14 January 2020

Theresa A Shapiro

5

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14 January 2020

language of work or name

English

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publication date

29 September 2008

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27 March 2017

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Antimicrobial Agents and Chemotherapy

14 January 2020

published in

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volume

53

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14 January 2020

issue

1

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page(s)

123-128

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Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay

14 January 2020

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Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis

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3 June 2018

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Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors

3 June 2018

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Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen

3 June 2018

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DNA topoisomerases as targets for antiprotozoal therapy

3 June 2018

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Current chemotherapy of human African trypanosomiasis

3 June 2018

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An unusual type IB topoisomerase from African trypanosomes

3 June 2018

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Recent developments in human African trypanosomiasis

3 June 2018

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Polyamine metabolism as chemotherapeutic target in protozoan parasites

3 June 2018

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Mechanism of action of camptothecin

3 June 2018

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Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice

3 June 2018

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Nuclear and genome organization of Trypanosoma brucei

3 June 2018

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Antitrypanosomal activity of a new triazine derivative, SIPI 1029, In vitro and in model infections

3 June 2018

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Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison.

3 June 2018

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Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania

3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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26 November 2018

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12 December 2020

Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities

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12 December 2020

Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring A substituted camptothecin analogues. Structure-activity correlations

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12 December 2020

Relationship between the intracellular effects of camptothecin and the inhibition of DNA topoisomerase I in cultured L1210 cells

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12 December 2020

Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons

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12 December 2020

Regression of human breast carcinoma tumors in immunodeficient mice treated with 9-nitrocamptothecin: differential response of nontumorigenic and tumorigenic human breast cells in vitro

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12 December 2020

Complete inhibition of growth followed by death of human malignant melanoma cells in vitro and regression of human melanoma xenografts in immunodeficient mice induced by camptothecins

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12 December 2020

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

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12 December 2020

Identifiers

DOI

10.1128/AAC.00650-07

2 references

27 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18824603%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18824603%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference