The tachykinin NK1 receptor. Part I: Ligands and mechanisms of cellular activation (Q29306227)

Europe PubMed Central

title

The tachykinin NK1 receptor. Part I: Ligands and mechanisms of cellular activation (English)

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https://doi.org/10.1016%2FS0143-4179%2897%2990001-9

9 April 2017

0 references

L Quartara

1

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https://doi.org/10.1016%2FS0143-4179%2897%2990001-9

9 April 2017

C.A Maggi

series ordinal

2

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https://doi.org/10.1016%2FS0143-4179%2897%2990001-9

9 April 2017

publication date

December 1997

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https://doi.org/10.1016%2FS0143-4179%2897%2990001-9

9 April 2017

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https://doi.org/10.1016%2FS0143-4179%2897%2990001-9

9 April 2017

volume

31

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https://doi.org/10.1016%2FS0143-4179%2897%2990001-9

9 April 2017

issue

6

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https://doi.org/10.1016%2FS0143-4179%2897%2990001-9

9 April 2017

page(s)

537-563

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https://doi.org/10.1016%2FS0143-4179%2897%2990001-9

Multiple tachykinin binding sites in peripheral tissues and in brain

9 April 2017

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Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P

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Synthesis and in vitro activities of new tryptophan-modified and thiomethylene-containing pseudopeptide antagonists of the neurokinins

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Studies on neurokinin antagonists. 4. Synthesis and structure-activity relationships of novel dipeptide substance P antagonists: N2-[(4R)-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl]-N- methyl-N-(phenylmethyl)-3-(2-naphthyl)-L-alaninamid

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A water-soluble, stable dipeptide NK1 receptor-selective neurokinin receptor antagonist with potent in vivo pharmacological effects: S18523.

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Synthesis and biological evaluation of novel NK-1 tachykinin receptor antagonists: the use of cycloalkyl amino acids as a template

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7 January 2021

Imidazo[4,5-b]quinoxaline cyanines as neurokinin antagonists

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Synthesis and substance P antagonist activity of naphthimidazolium derivatives

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Synthesis and substance P receptor binding activity of androstano[3,2-b]pyrimido[1,2-a]benzimidazoles

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Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists

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A Potent Nonpeptide Antagonist of the Substance P (NK 1 ) Receptor

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The discovery of (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1- azabicyclo[2.2.2]-octan-3-amine as a novel, nonpeptide substance P antagonisst

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7 January 2021

Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK 1 ) Receptor Antagonist

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Aza-Tricyclic Substance P Antagonists

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Identification of a series of 3-(benzyloxy)-1-azabicyclo[2.2.2]octane human NK1 antagonists

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Discovery of a potent substance P antagonist: recognition of the key molecular determinant

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Importance of parallel vectors and "hydrophobic collapse" of the aligned aromatic rings: discovery of a potent substance P antagonist

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Discovery of an orally bioavailable NK1 receptor antagonist, (2S,3S)-(2-methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine (GR203040), with potent antiemetic activity

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4,4-Disubstituted piperidines: a new class of NK1 antagonist

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N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: a novel class of potent orally active human NK1 antagonists

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2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist

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7 January 2021

In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist

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7 January 2021

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Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor

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7 January 2021

Tryptophan-derived NK1 antagonists: conformationally constrained heterocyclic bioisosteres of the ester linkage

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7 January 2021

Synthesis and biological evaluation of NK1 antagonists derived from L-tryptophan

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7 January 2021

3-Aryl-1,2-diacetamidopropane derivatives as novel and potent NK-1 receptor antagonists

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7 January 2021

Novel, potent, and orally active substance P antagonists: synthesis and antagonist activity of N-benzylcarboxamide derivatives of pyrido[3,4-b]pyridine.

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7 January 2021

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7 January 2021

Molecular cloning of the murine substance K and substance P receptor genes

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7 January 2021

Molecular cloning of substance P receptor cDNA from guinea-pig uterus

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7 January 2021

Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345

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7 January 2021

Conserved HisVI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P.

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7 January 2021

Interaction of substance P with the second and seventh transmembrane domains of the neurokinin-1 receptor

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7 January 2021

Different binding epitopes on the NK1 receptor for substance P and non-peptide antagonist.

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7 January 2021

Conversion of antagonist-binding site to metal-ion site in the tachykinin NK-1 receptor.

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7 January 2021

Tachykinin receptor types: Classification and membrane signalling mechanisms

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7 January 2021

Regulation of substance P receptor affinity by guanine nucleotide-binding proteins

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7 January 2021

Chemical cross-linking of the substance P (NK-1) receptor to the alpha subunits of the G proteins Gq and G11

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7 January 2021

Conformational compatibility as a basis of differential affinities of tachykinins for the neurokinin-1 receptor

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7 January 2021

Multiple intracellular signaling pathways of the neuropeptide substance P receptor

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7 January 2021

Ligand Binding Kinetics of Substance P and Neurokinin A Receptors Stably Expressed in Chinese Hamster Ovary Cells and Evidence for Differential Stimulation of Inositol 1,4,5‐Trisphosphate and Cyclic AMP Second Messenger Responses

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7 January 2021

Thapsigargin blocks the mobilisation of intracellular calcium caused by activation of human NK1 (long) receptors expressed in Chinese hamster ovary cells

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7 January 2021

Multiple mechanisms of arachidonic acid release in Chinese hamster ovary cells transfected with cDNA of substance P receptor

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7 January 2021

Substance P stimulation of polyphosphoinositide hydrolysis in rat anterior pituitary membranes involves a GTP-dependent mechanism

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7 January 2021

Modulation of membrane K+ conductance in T-lymphocytes by substance P via a GTP-binding protein

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7 January 2021

Two signal transduction mechanisms of substance P-induced depolarization in locus coeruleus neurons.

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7 January 2021

Homologous desensitization of substance-P-induced inositol polyphosphate formation in rat parotid acinar cells

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7 January 2021

Agonist-induced internalization of the substance P (NK1) receptor expressed in epithelial cells

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7 January 2021

Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor

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7 January 2021

Attenuation of agonist-induced desensitization of the rat substance P receptor by progressive truncation of the C-terminus

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7 January 2021

Molecular cloning, structural characterization and functional expression of the human substance P receptor

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7 January 2021

Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones

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7 January 2021

Isolation and characterisation of the human lung NK-1 receptor cDNA

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7 January 2021

Biochemical Characterization of Two Different Forms of the Substance P Receptor in Rat Submaxillary Gland

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7 January 2021

Differential expression of two isoforms of the neurokinin-1 (substance P) receptor in vivo

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7 January 2021