The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway (Q29306901)

9 April 2017

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I Galve-Roperh

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Michael Sendtner

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M Sendtner

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author name string

C Blázquez

1

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9 April 2017

A Chiarlone

2

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9 April 2017

L Bellocchio

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9 April 2017

E Resel

4

1 reference

9 April 2017

P Pruunsild

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9 April 2017

D García-Rincón

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9 April 2017

T Timmusk

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9 April 2017

B Lutz

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9 April 2017

M Guzmán

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9 April 2017

publication date

20 February 2015

1 reference

Cell Death & Differentiation

9 April 2017

published in

1 reference

9 April 2017

volume

22

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9 April 2017

issue

10

1 reference

9 April 2017

page(s)

1618-1629

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Creative Commons Attribution 4.0 International

9 April 2017

copyright license

start time

20 February 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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ImageJ

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4563779/fullTextXML

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The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition

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A restricted population of CB1 cannabinoid receptors with neuroprotective activity

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A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease

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Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease

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Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development

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AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity

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BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice

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The multiplicity of action of cannabinoids: implications for treating neurodegeneration

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Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth.

3 June 2018

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Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors

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Brain-derived neurotrophic factor in neurodegenerative diseases

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A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition

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3 June 2018

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Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington's disease mice

3 June 2018

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Differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 after excitotoxicity in a rat model of Huntington's disease

3 June 2018

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Anterograde transport of brain-derived neurotrophic factor and its role in the brain.

3 June 2018

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3 June 2018

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Identification of brain-derived neurotrophic factor promoter regions mediating tissue-specific, axotomy-, and neuronal activity-induced expression in transgenic mice

3 June 2018

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Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

3 June 2018

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Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain

21 January 2018

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Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease.

21 January 2018

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Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

21 January 2018

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Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells

21 January 2018

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Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters

21 January 2018

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Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice

21 January 2018

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Metabolic and type 1 cannabinoid receptor imaging of a transgenic rat model in the early phase of Huntington disease.

21 January 2018

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Selective vulnerability in Huntington's disease: preferential loss of cannabinoid receptors in lateral globus pallidus.

21 January 2018

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The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease

21 January 2018

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Worsening of Huntington disease phenotype in CB1 receptor knockout mice

21 January 2018

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Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus

21 January 2018

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Agonist efficacy and receptor efficiency in heterozygous CB1 knockout mice: relationship of reduced CB1 receptor density to G-protein activation

21 January 2018

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Involvement of brain-derived neurotrophic factor in cannabinoid receptor-dependent protection against excitotoxicity

21 January 2018

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Changes in the expression of G protein-coupled receptor kinases and beta-arrestins in mouse brain during cannabinoid tolerance: a role for RAS-ERK cascade.

21 January 2018

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BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout mice

21 January 2018

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Depression-like phenotype following chronic CB1 receptor antagonism

21 January 2018

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A role for the endocannabinoid system in exercise-induced spatial memory enhancement in mice.

21 January 2018

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In vivo up-regulation of brain-derived neurotrophic factor in specific brain areas by chronic exposure to Delta-tetrahydrocannabinol

21 January 2018

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Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin.

21 January 2018

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Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum.

21 January 2018

1 reference

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Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis.

21 January 2018

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The endogenous cannabinoid system controls extinction of aversive memories

21 January 2018

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Altered expression of the CB1 cannabinoid receptor in the triple transgenic mouse model of Alzheimer's disease.

21 January 2018

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Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus.

26 November 2018

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Expression of the striatal DARPP-32/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro.

26 November 2018

1 reference

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Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25698444

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12 December 2020

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Identifiers

DOI

10.1038/CDD.2015.11

2 references

9 April 2017

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3973147

1010226159

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Fatcat ID

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24 November 2022

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3973147

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1 reference

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