Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase. (Q29347297)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21402738%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase (English)

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25 January 2020

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1 reference

GOA release 2020-03-11

author

Jiyoun Lee

3

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25 January 2020

Gregory M Barton

6

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25 January 2020

5

Matthew Bogyo

1 reference

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25 January 2020

author name string

Sarah E Ewald

1

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25 January 2020

Alex Engel

2

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25 January 2020

Miqi Wang

4

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25 January 2020

language of work or name

English

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publication date

14 March 2011

1 reference

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Journal of Experimental Medicine

25 January 2020

published in

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25 January 2020

volume

208

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25 January 2020

issue

4

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25 January 2020

page(s)

643-651

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Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

25 January 2020

cites work

1 reference

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The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

11 April 2017

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Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

11 April 2017

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UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

11 April 2017

1 reference

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The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

11 April 2017

1 reference

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The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

11 April 2017

1 reference

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The evolution of vertebrate Toll-like receptors

11 April 2017

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Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice

11 April 2017

1 reference

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Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3

11 April 2017

1 reference

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Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain

3 June 2018

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The toll-like receptor 3:dsRNA signaling complex

3 June 2018

1 reference

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Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation

3 June 2018

1 reference

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Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.

3 June 2018

1 reference

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Cathepsins are required for Toll-like receptor 9 responses

3 June 2018

1 reference

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Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity

3 June 2018

1 reference

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Ligand-induced conformational changes allosterically activate Toll-like receptor 9.

3 June 2018

1 reference

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The dsRNA binding site of human Toll-like receptor 3.

3 June 2018

1 reference

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Lysosomal cysteine proteases and antigen presentation.

3 June 2018

1 reference

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Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction

3 June 2018

1 reference

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Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

3 June 2018

1 reference

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Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells

3 June 2018

1 reference

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Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation

26 November 2018

1 reference

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Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

26 November 2018

1 reference

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Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice.

26 November 2018

1 reference

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Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate

26 November 2018

1 reference

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26 November 2018

Identifiers

DOI

10.1084/JEM.20100682

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21402738%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21402738%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

PubMed publication ID

21402738

2 references