Mammalian Rho GTPases: new insights into their functions from in vivo studies (Q29615191)

Europe PubMed Central

title

Mammalian Rho GTPases: new insights into their functions from in vivo studies (English)

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30 April 2017

author name string

Heasman SJ

series ordinal

1

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30 April 2017

Ridley AJ

series ordinal

2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18719708

30 April 2017

language of work or name

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30 April 2017

publication date

September 2008

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Nature Reviews Molecular Cell Biology

30 April 2017

published in

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volume

9

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30 April 2017

issue

9

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30 April 2017

page(s)

690-701

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Rho GTPases: biochemistry and biology

30 April 2017

cites work

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Taking Rho GTPases to the next level: the cellular functions of atypical Rho GTPases

31 March 2020

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Function and regulation of Rnd proteins

31 March 2020

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Evolution of the Rho family of ras-like GTPases in eukaryotes

31 March 2020

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Cdc42--the centre of polarity

31 March 2020

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Functional analysis of Cdc42 in actin filament assembly, epithelial morphogenesis, and cell signaling during Drosophila development.

31 March 2020

1 reference

CDC-42 controls early cell polarity and spindle orientation in C. elegans

31 March 2020

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Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability

31 March 2020

1 reference

Filopodia: the fingers that do the walking

31 March 2020

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Distinct cellular effects and interactions of the Rho-family GTPase TC10.

31 March 2020

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Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1

31 March 2020

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Rho GTPases have diverse effects on the organization of the actin filament system

31 March 2020

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Cdc42 regulates cofilin during the establishment of neuronal polarity.

31 March 2020

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Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts

31 March 2020

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Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells

31 March 2020

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N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility

31 March 2020

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Disruption of the Diaphanous-related formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42

31 March 2020

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Membrane Curvature: The Power of Bananas, Zeppelins and Boomerangs

31 March 2020

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The role of the Rho GTPases in neuronal development

31 March 2020

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Cdc42 participates in the regulation of ADF/cofilin and retinal growth cone filopodia by brain derived neurotrophic factor

31 March 2020

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Brain-derived neurotrophic factor regulation of retinal growth cone filopodial dynamics is mediated through actin depolymerizing factor/cofilin.

31 March 2020

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The cofilin pathway in breast cancer invasion and metastasis

31 March 2020

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Rho GTPases regulate axon growth through convergent and divergent signaling pathways.

31 March 2020

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Mechanisms of axon ensheathment and myelin growth

31 March 2020

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Cdc42 and Rac1 Signaling Are Both Required for and Act Synergistically in the Correct Formation of Myelin Sheaths in the CNS

31 March 2020

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Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development

31 March 2020

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Chemokine-induced monocyte transmigration requires cdc42-mediated cytoskeletal changes.

31 March 2020

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A role for Cdc42 in macrophage chemotaxis

31 March 2020

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Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes

31 March 2020

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Rho GTPases control polarity, protrusion, and adhesion during cell movement

31 March 2020

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Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration

31 March 2020

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Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow

31 March 2020

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Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis

31 March 2020

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Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development

31 March 2020

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Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils

31 March 2020

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Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization

31 March 2020

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The PAR proteins: fundamental players in animal cell polarization

31 March 2020

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Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity

31 March 2020

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The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity

31 March 2020

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Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells

31 March 2020

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Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic

31 March 2020

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Parsing the polarity code

31 March 2020

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Rho GTPases in cell biology

31 March 2020

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PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.

31 March 2020

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Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin

31 March 2020

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Cdc42 expression in keratinocytes is required for the maintenance of the basement membrane in skin

31 March 2020

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The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface

31 March 2020

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Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly

31 March 2020

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Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis

31 March 2020

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RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo

31 March 2020

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Characterization of RAC3, a novel member of the Rho family

31 March 2020

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Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiation.

31 March 2020

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Generation and characterization of Rac3 knockout mice.

31 March 2020

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Growth-regulated expression of rhoG, a new member of the ras homolog gene family

31 March 2020

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Rac1 is required for the formation of three germ layers during gastrulation.

31 March 2020

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Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration.

31 March 2020

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Beta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination

31 March 2020

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An essential role for Rac1 in endothelial cell function and vascular development.

31 March 2020

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Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.

31 March 2020

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Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass

31 March 2020

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Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

31 March 2020

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Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases

31 March 2020

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Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles

31 March 2020

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Rac1 and Rac2 regulate macrophage morphology but are not essential for migration

31 March 2020

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RhoG regulates the neutrophil NADPH oxidase

31 March 2020

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The WASP-WAVE protein network: connecting the membrane to the cytoskeleton

31 March 2020

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Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptor

31 March 2020

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Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions

31 March 2020

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Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton

31 March 2020

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Rho GTPases and their regulators in neuronal functions and development

31 March 2020

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Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion

31 March 2020

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Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42.

31 March 2020

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Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons

31 March 2020

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Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance.

31 March 2020

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The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth

31 March 2020

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Kalirin Dbl-homology guanine nucleotide exchange factor 1 domain initiates new axon outgrowths via RhoG-mediated mechanisms

31 March 2020

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Overexpression of a neural-specific rho family GTPase, cRac1B, selectively induces enhanced neuritogenesis and neurite branching in primary neurons.

31 March 2020

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Hyperactivity and novelty-induced hyperreactivity in mice lacking Rac3.

31 March 2020

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Functions of Rac GTPases during neuronal development.

31 March 2020

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Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines.

31 March 2020

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Normal levels of Rac1 are important for dendritic but not axonal development in hippocampal neurons.

31 March 2020

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Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta1

31 March 2020

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Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes

31 March 2020

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Rac2 specificity in macrophage integrin signaling: potential role for Syk kinase

31 March 2020

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Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly.

31 March 2020

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Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions.

31 March 2020

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Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure.

31 March 2020

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Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization

31 March 2020

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Function of Rho family proteins in actin dynamics during phagocytosis and engulfment

31 March 2020

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Actin dynamics during phagocytosis

31 March 2020

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Involvement of the Arp2/3 complex in phagocytosis mediated by FcgammaR or CR3.

31 March 2020

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Phagocytosis of microbes: complexity in action

31 March 2020

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Clearance of apoptotic cells by phagocytes

31 March 2020

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Opposite effects of rho family GTPases on engulfment of apoptotic cells by macrophages

31 March 2020

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Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO

31 March 2020

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The role of Rac1 and Rac2 in bacterial killing

31 March 2020

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Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis.

31 March 2020

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Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis.

31 March 2020

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How human neutrophils kill and degrade microbes: an integrated view

31 March 2020

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Regulation of neutrophil function by Rac GTPases

31 March 2020

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Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways

31 March 2020

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Rac2 is critical for neutrophil primary granule exocytosis.

31 March 2020

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Requirement of Rac1 in the development of cardiac hypertrophy.

31 March 2020

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Identifying the relative contributions of Rac1 and Rac2 to osteoclastogenesis

31 March 2020

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Rac1 GTPase regulates cell genomic stability and senescence.

31 March 2020

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Reactive oxygen species in tumor progression

31 March 2020

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Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility

31 March 2020

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RhoB-dependent modulation of postendocytic traffic in polarized Madin-Darby canine kidney cells.

31 March 2020

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RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells

31 March 2020

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RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis

31 March 2020

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Regulation of endocytic traffic by rho family GTPases.

31 March 2020

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Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking

31 March 2020

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Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase

31 March 2020

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Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB

31 March 2020

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RhoB regulates PDGFR-beta trafficking and signaling in vascular smooth muscle cells

31 March 2020

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Not just a sink: endosomes in control of signal transduction

31 March 2020

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RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development

31 March 2020

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Rho GTPases in cancer cell biology

31 March 2020

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RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1.

31 March 2020

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RhoC induces differential expression of genes involved in invasion and metastasis in MCF10A breast cells

31 March 2020

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Genomic analysis of metastasis reveals an essential role for RhoC

31 March 2020

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RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility

31 March 2020

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RhoC is essential for the metastasis of gastric cancer

31 March 2020

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Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma

31 March 2020

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Tumour invasion and metastasis initiated by microRNA-10b in breast cancer

31 March 2020

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ROCK and Dia have opposing effects on adherens junctions downstream of Rho

31 March 2020

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Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis

31 March 2020

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RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

31 March 2020

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The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function

31 March 2020

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Structural features of hematopoiesis-specific RhoH/ARHH gene: high diversity of 5'-UTR in different hematopoietic lineages suggests a complex post-transcriptional regulation

31 March 2020

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RhoH, a hematopoietic-specific Rho GTPase, regulates proliferation, survival, migration, and engraftment of hematopoietic progenitor cells

31 March 2020

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RhoH is important for positive thymocyte selection and T-cell receptor signaling

31 March 2020

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Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells

31 March 2020

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RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes

31 March 2020

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Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase

31 March 2020

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Positive and negative regulation of T-cell activation through kinases and phosphatases

31 March 2020

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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

31 March 2020

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Catching a GEF by its tail

31 March 2020

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Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases

31 March 2020

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Current knowledge of the large RhoGAP family of proteins

31 March 2020

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Cell type-specific functions of Rho GTPases revealed by gene targeting in mice.

31 March 2020

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RhoGDI: multiple functions in the regulation of Rho family GTPase activities

31 March 2020

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The many faces of actin: matching assembly factors with cellular structures

31 March 2020

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TCR signaling: another Abl-bodied kinase joins the cascade

31 March 2020

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31 March 2020

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553024

1012018803

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Consolidated OpenCitations Corpus – April 2017