Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain (Q29615210)

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=10839993

30 April 2017

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Owen MR

1

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30 April 2017

Doran E

series ordinal

2

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30 April 2017

Halestrap AP

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3

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30 April 2017

publication date

15 June 2000

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30 April 2017

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30 April 2017

volume

348 Pt 3

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30 April 2017

page(s)

607-14

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Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

30 April 2017

cites work

1 reference

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Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin

3 June 2018

1 reference

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Translocation of two glucose transporters in heart: effects of rotenone, uncouplers, workload, palmitate, insulin and anoxia

3 June 2018

1 reference

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Action of metformin on glucose transport and glucose transporter GLUT1 and GLUT4 in heart muscle cells from healthy and diabetic rats

3 June 2018

1 reference

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Effects of metformin treatment on glucose transporter proteins in subcellular fractions of skeletal muscle in (fa/fa) Zucker rats

3 June 2018

1 reference

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Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences

3 June 2018

1 reference

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The mechanism of action of phenformin in starved rats

3 June 2018

1 reference

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Rat liver mitochondria prepared in mannitol media demonstrate increased mitochondrial volumes compared with mitochondria prepared in sucrose media. Relationship to the effect of glucagon on mitochondrial function

3 June 2018

1 reference

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Biguanides. A review of history, pharmacodynamics and therapy

3 June 2018

1 reference

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Effects of guanidine derivatives on mitochondrial function. 3. The mechanism of phenethylbiguanide accumulation and its relationship to in vitro respiratory inhibition.

3 June 2018

1 reference

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Intramitochondrial regulation of fatty acid beta-oxidation occurs between flavoprotein and ubiquinone. A role for changes in the matrix volume

3 June 2018

1 reference

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The regulation of the oxidation of fatty acids and other substrates in rat heart mitochondria by changes in the matrix volume induced by osmotic strength, valinomycin and Ca2+.

3 June 2018

1 reference

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Evidence that the flux control coefficient of the respiratory chain is high during gluconeogenesis from lactate in hepatocytes from starved rats. Implications for the hormonal control of gluconeogenesis and action of hypoglycaemic agents

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221104

Inhibition of hepatic gluconeogenesis by metformin. Synergism with insulin.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221104

Hypoglycaemic effect of metformin in genetically obese (fa/fa) rats results from an increased utilization of blood glucose by intestine

3 June 2018

1 reference

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Binding of ADP to rat liver cytosolic proteins and its influence on the ratio of free ATP/free ADP.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221104

Energetics of Ehrlich ascites mitochondria: membrane potential of isolated mitochondria and mitochondria within digitonin-permeabilized cells.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221104

Association of Metformin's Effect to Increase Insulin-Stimulated Glucose Transport With Potentiation of Insulin-Induced Translocation of Glucose Transporters From Intracellular Pool to Plasma Membrane in Rat Adipocytes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221104

Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells

3 June 2018

1 reference

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Biguanide-associated lactic acidosis. Case report and review of the literature

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221104

Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221104

Possible role of intracellular Ca2+ in the toxicity of phenformin

26 November 2018

1 reference

12 December 2020

Sites of metformin-stimulated glucose metabolism

1 reference

12 December 2020

The mechanisms by which mild respiratory chain inhibitors inhibit hepatic gluconeogenesis

1 reference

12 December 2020

Metformin increases glucose transporter protein and gene expression in human fibroblasts

1 reference

12 December 2020

Metformin improves cardiac function in isolated streptozotocin-diabetic rat hearts

1 reference

12 December 2020

Accumulation of metformin by tissues of the normal and diabetic mouse

1 reference

12 December 2020

Acute antihyperglycemic mechanisms of metformin in NIDDM. Evidence for suppression of lipid oxidation and hepatic glucose production

1 reference

12 December 2020

Studies on the characterization of the inhibitory mechanism of 4'-alkylated 1-methyl-4-phenylpyridinium and phenylpyridine analogues in mitochondria and electron transport particles

1 reference

12 December 2020

Effects of metformin on lactate uptake and gluconeogenesis in the perfused rat liver

1 reference

12 December 2020

The effect of alkylguanidines on mitochondrial metabolism

1 reference

12 December 2020

Mode of action of hypoglycemic agents. V. Studies with phenethylbiguanide in isolated perfused rat liver

1 reference

12 December 2020

Glucagon treatment stimulates the metabolism of hepatic submitochondrial particles

1 reference

12 December 2020

10.1042/0264-6021:3480607

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

197598

197598

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=10839993

1 reference

30 April 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=10839993

30 April 2017

Consolidated OpenCitations Corpus – April 2017