Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery (Q29615235)

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=8349823

30 April 2017

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Ishibashi S

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30 April 2017

Brown MS

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Goldstein JL

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Gerard RD

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Hammer RE

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Herz J

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30 April 2017

language of work or name

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30 April 2017

publication date

August 1993

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Journal of Clinical Investigation

30 April 2017

published in

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volume

92

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page(s)

883-93

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issue

2

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Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells

30 April 2017

cites work

1 reference

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Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor

30 April 2017

1 reference

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The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA

30 April 2017

1 reference

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Familial apolipoprotein E deficiency

30 April 2017

1 reference

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A receptor-mediated pathway for cholesterol homeostasis

30 April 2017

1 reference

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Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

30 April 2017

1 reference

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Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

30 April 2017

1 reference

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Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins

30 April 2017

1 reference

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Altering the genome by homologous recombination

30 April 2017

1 reference

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The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

30 April 2017

1 reference

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Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294927

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

30 April 2017

1 reference

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Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E

30 April 2017

1 reference

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Molecular genetics of the LDL receptor gene in familial hypercholesterolemia

30 April 2017

1 reference

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Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice

30 April 2017

1 reference

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Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids

3 June 2018

1 reference

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Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits

3 June 2018

1 reference

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Apolipoprotein B (B-48) of rat chylomicrons is not a precursor of the apolipoprotein of low density lipoproteins

3 June 2018

1 reference

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Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits

3 June 2018

1 reference

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The effect of selective breeding on the development of coronary atherosclerosis in WHHL rabbits. An animal model for familial hypercholesterolemia.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294927

Effect of low density lipoprotein receptor deficiency on the metabolism of apolipoprotein B-100 in blood plasma. Kinetic studies in normal and Watanabe heritable hyperlipidemic rabbits

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294927

Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice

3 June 2018

1 reference

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Genetically determined hypercholesterolemia in a rhesus monkey family due to a deficiency of the LDL receptor.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294927

Metabolism of apolipoprotein B-100 in large very low density lipoproteins of blood plasma. Kinetic studies in normal and Watanabe heritable hyperlipidemic rabbits

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294927

Evidence for a dominant gene that suppresses hypercholesterolemia in a family with defective low density lipoprotein receptors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294927

Apolipoprotein B metabolism in homozygous familial hypercholesterolemia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294927

The molecular and cell biology of apolipoprotein-B.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294927

Interaction of dietary cholesterol and triglycerides in the regulation of hepatic low density lipoprotein transport in the hamster

3 June 2018

1 reference

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Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors

3 June 2018

1 reference

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Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic mice

3 June 2018

1 reference

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A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia

3 June 2018

1 reference

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Long-Term Improvement of Hypercholesterolemia After Ex Vivo Gene Therapy in LDLR-Deficient Rabbits

3 June 2018

1 reference

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The low density lipoprotein receptor in Xenopus laevis. I. Five domains that resemble the human receptor

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294927

Cytoplasmic sequence required for basolateral targeting of LDL receptor in livers of transgenic mice

3 June 2018

1 reference

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Developmental and age-related changes in apolipoprotein B mRNA editing in mice.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294927

Apolipoprotein B, the major protein component of triglyceride-rich and low density lipoproteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294927

Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterolemia in low density lipoprotein receptor-deficient rabbits

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294927

Metabolic studies in familial hypercholesterolemia. Evidence for a gene-dosage effect in vivo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294927

Comparison between the use of isopropanol and tetramethylurea for the solubilisation and quantitation of human serum very low density apollpoproteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294927

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294927

Receptor-dependent and receptor-independent degradation of low density lipoprotein in normal rabbits and in receptor-deficient mutant rabbits

26 November 2018

1 reference

12 December 2020

The metabolism of very low density and intermediate density lipoproteins in patients with familial hypercholesterolaemia

1 reference

12 December 2020

Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia

1 reference

12 December 2020

19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

1 reference

12 December 2020

Role of receptor-independent low density lipoprotein transport in the maintenance of tissue cholesterol balance in the normal and WHHL rabbit

1 reference

12 December 2020

Evaluation of the transfer and expression in mice of an enzyme-encoding gene using a human adenovirus vector

1 reference

12 December 2020

The NHLBI Twin Study: heritability of apolipoprotein A-I, B, and low density lipoprotein subclasses and concordance for lipoprotein(a)

1 reference

12 December 2020

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=8349823

Identifiers

2 references

30 April 2017

42883

42883

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=8349823

2 references

30 April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=8349823

2 references

30 April 2017