Iron, brain ageing and neurodegenerative disorders (Q29615656)

Europe PubMed Central

title

Iron, brain ageing and neurodegenerative disorders (English)

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30 April 2017

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2

Moussa B. H. Youdim

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Luigi Zecca

1

object named as

Luigi Zecca

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Peter Riederer

3

object named as

Peter Riederer

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James R. Connor

4

object named as

James R. Connor

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author name string

Robert R. Crichton

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5

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language of work or name

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30 April 2017

publication date

November 2004

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Nature Reviews Neuroscience

30 April 2017

published in

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30 April 2017

volume

5

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30 April 2017

issue

11

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30 April 2017

page(s)

863-73

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A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

30 April 2017

cites work

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Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

1 May 2017

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Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

1 May 2017

1 reference

Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family

1 May 2017

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Iron regulatory proteins and the molecular control of mammalian iron metabolism

1 May 2017

1 reference

Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

1 May 2017

1 reference

Risperidone-induced tardive dystonia and psychosis

1 May 2017

1 reference

Neurovascular regulation in the normal brain and in Alzheimer's disease

1 May 2017

1 reference

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

1 May 2017

1 reference

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

1 May 2017

1 reference

A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans

1 May 2017

1 reference

Friedreich ataxia: from GAA triplet-repeat expansion to frataxin deficiency

1 May 2017

1 reference

A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome

1 May 2017

1 reference

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

1 May 2017

1 reference

Iron homeostasis: insights from genetics and animal models

1 May 2017

1 reference

The iron transporter DMT1.

31 March 2020

1 reference

Chemistry and biology of eukaryotic iron metabolism

31 March 2020

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Brain iron uptake and homeostatic mechanisms: an overview

31 March 2020

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The history of iron in the brain

31 March 2020

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Isoforms of ferritin have a specific cellular distribution in the brain.

31 March 2020

1 reference

The metabolism of neuronal iron and its pathogenic role in neurological disease: review

31 March 2020

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The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging

31 March 2020

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Interaction of neuromelanin and iron in substantia nigra and other areas of human brain

31 March 2020

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Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles.

31 March 2020

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Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics

31 March 2020

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The structure of neuromelanin as studied by chemical degradative methods

31 March 2020

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Expression of transferrin mRNA in the CNS of normal and jimpy mice.

31 March 2020

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Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome

31 March 2020

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Alternative splicing prevents transferrin secretion during differentiation of a human oligodendrocyte cell line

31 March 2020

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Distribution of transferrin and ferritin binding in normal and multiple sclerotic human brains.

31 March 2020

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The effect of age on the non-haemin iron in the human brain.

31 March 2020

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A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains

31 March 2020

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Age-associated increases in heme oxygenase-1 and ferritin immunoreactivity in the autopsied brain.

31 March 2020

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Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains

31 March 2020

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MR evaluation of age-related increase of brain iron in young adult and older normal males

31 March 2020

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Increasing striatal iron content associated with normal aging.

31 March 2020

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The correlation between phase shifts in gradient-echo MR images and regional brain iron concentration.

31 March 2020

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A white matter disorder in dementia of the Alzheimer type: a pathoanatomical study.

31 March 2020

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Healthy aging and dementia: findings from the Nun Study

31 March 2020

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Brain iron and ferritin in Parkinson's and Alzheimer's diseases.

31 March 2020

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Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

31 March 2020

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Increased nigral iron content in postmortem parkinsonian brain.

31 March 2020

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Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis

31 March 2020

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The relevance of iron in the pathogenesis of Parkinson's disease.

31 March 2020

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Iron in parkinsonian and control substantia nigra--a Mössbauer spectroscopy study

31 March 2020

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Iron in the basal ganglia in Parkinson's disease. An in vitro study using extended X-ray absorption fine structure and cryo-electron microscopy

31 March 2020

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Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia

31 March 2020

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Iron-melanin complex in substantia nigra of parkinsonian brains: an x-ray microanalysis

31 March 2020

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The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons.

31 March 2020

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Iron-binding characteristics of neuromelanin of the human substantia nigra.

31 March 2020

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Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study

31 March 2020

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Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson's disease

31 March 2020

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Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease

31 March 2020

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Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson's disease

31 March 2020

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Echogenicity of the substantia nigra: association with increased iron content and marker for susceptibility to nigrostriatal injury

31 March 2020

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Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease.

31 March 2020

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Neural heme oxygenase-1 expression in idiopathic Parkinson's disease.

31 March 2020

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Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders

31 March 2020

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The density of [125I]-transferrin binding sites on perikarya of melanized neurons of the substantia nigra is decreased in Parkinson's disease.

31 March 2020

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Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson disease

31 March 2020

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Cellular distribution of the iron-binding protein lactotransferrin in the mesencephalon of Parkinson's disease cases

31 March 2020

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Lack of up-regulation of ferritin is associated with sustained iron regulatory protein-1 binding activity in the substantia nigra of patients with Parkinson's disease.

31 March 2020

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Association study between iron-related genes polymorphisms and Parkinson's disease

31 March 2020

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Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.

31 March 2020

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Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallate

31 March 2020

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The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

31 March 2020

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Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

31 March 2020

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Crosslinking of alpha-synuclein by advanced glycation endproducts--an early pathophysiological step in Lewy body formation?

31 March 2020

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Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease

31 March 2020

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Regional distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer's disease

31 March 2020

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Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress.

31 March 2020

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31 March 2020

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An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

31 March 2020

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Alzheimer's disease, beta-amyloid protein and zinc

31 March 2020

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Redox-active iron mediates amyloid-beta toxicity

31 March 2020

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Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide.

31 March 2020

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The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications

31 March 2020

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Metal complexing agents as therapies for Alzheimer's disease

31 March 2020

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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

31 March 2020

1 reference

Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats

31 March 2020

1 reference

Is hemochromatosis a risk factor for Alzheimer's disease?

31 March 2020

1 reference

Regulation of Hfe by stress factors in BV-2 cells.

31 March 2020

1 reference

Are hereditary hemochromatosis mutations involved in Alzheimer disease?

31 March 2020

1 reference

Staging of Alzheimer-related cortical destruction

31 March 2020

1 reference

Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE

31 March 2020

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Association of transferrin C2 allele with late-onset Alzheimer's disease.

31 March 2020

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Transferrin C2, metal binding and Alzheimer's disease.

31 March 2020

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Transferrin C2 variant does confer a risk for Alzheimer's disease in caucasians.

31 March 2020

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Transferrin gene polymorphism in Alzheimer's disease and dementia with Lewy bodies in humans.

31 March 2020

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Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease.

31 March 2020

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Iron misregulation in the brain: a primary cause of neurodegenerative disorders

31 March 2020

1 reference

The copper-iron connection: hereditary aceruloplasminemia

31 March 2020

1 reference

Aceruloplasminemia: molecular characterization of this disorder of iron metabolism

31 March 2020

1 reference

Use of desferrioxamine in the treatment of aceruloplasminemia

31 March 2020

1 reference

Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux

31 March 2020

1 reference

Glutamine repeats and neurodegeneration

31 March 2020

1 reference

Friedreich's ataxia and iron metabolism

31 March 2020

1 reference

The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins

31 March 2020

1 reference

Friedreich's Ataxia: disease mechanisms, antioxidant and Coenzyme Q10 therapy

31 March 2020

1 reference

Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease

31 March 2020

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Neuroferritinopathy: a window on the role of iron in neurodegeneration.

31 March 2020

1 reference

Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene

31 March 2020

1 reference

Unraveling the Hallervorden-Spatz syndrome: pantothenate kinase-associated neurodegeneration is the name

31 March 2020

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Iron status and neural functioning

31 March 2020

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Clinical practice. Restless legs syndrome

31 March 2020

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The possible role of iron in the etiopathology of Parkinson's disease

31 March 2020

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Hereditary causes of disturbed iron homeostasis in the central nervous system

31 March 2020

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Neurodegenerative diseases and oxidative stress

31 March 2020

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Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28.

31 March 2020

1 reference

Quinacrine attenuates increases in divalent metal transporter-1 and iron levels in the rat hippocampus, after kainate-induced neuronal injury

31 March 2020

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Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs

31 March 2020

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Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiparkinsonian African green monkey: evidence from proton microprobe elemental microanalysis.

31 March 2020

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Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study

31 March 2020

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Nutritional iron deprivation attenuates kainate-induced neurotoxicity in rats: implications for involvement of iron in neurodegeneration

31 March 2020

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Glutathione, iron and Parkinson's disease

31 March 2020

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Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

31 March 2020

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The antioxidant ebselen prevents neurotoxicity and clinical symptoms in a primate model of Parkinson's disease

31 March 2020

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Antioxidants as treatment for neurodegenerative disorders

31 March 2020

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Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases.

31 March 2020

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Metal and inflammatory targets for Alzheimer's disease

31 March 2020

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Rasagiline: an anti-Parkinson drug with neuroprotective activity

31 March 2020

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Effects of desferrithiocin and its derivatives on peripheral iron and striatal dopamine and 5-hydroxytryptamine metabolism in the ferrocene-loaded rat.

31 March 2020

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Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models.

31 March 2020

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Regional metal concentrations in Parkinson's disease, other chronic neurological diseases, and control brains

31 March 2020

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7 January 2021

Altered brain metabolism of iron as a cause of neurodegenerative diseases?

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7 January 2021

Iron levels modulate alpha-secretase cleavage of amyloid precursor protein

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7 January 2021

Oxidative stress, mitochondrial respiration, and Parkinson's disease.

1 reference

7 January 2021

Understanding cell death in Parkinson's disease.

1 reference

7 January 2021

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

5395

1001839101

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5395

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Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15496864

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30 April 2017

Consolidated OpenCitations Corpus – April 2017